5X67
Human thymidylate synthase in complex with dUMP and nolatrexed
Summary for 5X67
Entry DOI | 10.2210/pdb5x67/pdb |
Related | 5X4W 5X4X 5X4Y 5X5A 5X5D 5X5Q 5X66 5X69 |
Descriptor | Thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-azanyl-6-methyl-5-pyridin-4-ylsulfanyl-3H-quinazolin-4-one, ... (4 entities in total) |
Functional Keywords | methyltransferase, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P04818 |
Total number of polymer chains | 2 |
Total formula weight | 67693.29 |
Authors | Chen, D.,Jansson, A.,Larsson, A.,Nordlund, P. (deposition date: 2017-02-21, release date: 2017-06-28, Last modification date: 2023-11-22) |
Primary citation | Chen, D.,Jansson, A.,Sim, D.,Larsson, A.,Nordlund, P. Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states. J. Biol. Chem., 292:13449-13458, 2017 Cited by PubMed: 28634233DOI: 10.1074/jbc.M117.787267 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.13 Å) |
Structure validation
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