5X67
Human thymidylate synthase in complex with dUMP and nolatrexed
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Thymidylate synthase | polymer | 290 | 33254.1 | 2 | UniProt (P04818) Pfam (PF00303) | Homo sapiens (Human) | TSase |
| 2 | C, E (A, B) | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | non-polymer | 308.2 | 2 | Chemie (UMP) PubChem (688) PubChem (65063) PubChem (446899) PubChem (446900) PubChem (57164254) PubChem (71773959) PubChem (92144438) PubChem (92209480) PubChem (92209481) PubChem (92209482) PubChem (92449733) PubChem (133126534) | |||
| 3 | D, F (A, B) | 2-azanyl-6-methyl-5-pyridin-4-ylsulfanyl-3H-quinazolin-4-one | non-polymer | 284.3 | 2 | Chemie (7Z9) PubChem (135400184) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 267 | Chemie (HOH) |
Sequence modifications
A, B: 26 - 313 (UniProt: P04818)
| PDB | External Database | Details |
|---|---|---|
| Ser 24 | - | expression tag |
| Met 25 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66508.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1185.0 | |
| All* | Total formula weight | 67693.3 |
