Summary for 5B7V
Entry DOI | 10.2210/pdb5b7v/pdb |
Descriptor | Fibroblast growth factor receptor 1, [5-amino-1-(2-methyl-1H-benzimidazol-6-yl)-1H-pyrazol-4-yl](1H-indol-2-yl)methanone, SULFATE ION, ... (4 entities in total) |
Functional Keywords | protein kinase, atp-binding, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane; Single-pass type I membrane protein: P11362 |
Total number of polymer chains | 2 |
Total formula weight | 71426.05 |
Authors | Fukami, T.A.,Lukacs, C.M.,Janson, C. (deposition date: 2016-06-09, release date: 2016-06-22, Last modification date: 2023-11-08) |
Primary citation | Nakanishi, Y.,Akiyama, N.,Tsukaguchi, T.,Fujii, T.,Sakata, K.,Sase, H.,Isobe, T.,Morikami, K.,Shindoh, H.,Mio, T.,Ebiike, H.,Taka, N.,Aoki, Y.,Ishii, N. The fibroblast growth factor receptor genetic status as a potential predictor of the sensitivity to CH5183284/Debio 1347, a novel selective FGFR inhibitor Mol.Cancer Ther., 13:2547-2558, 2014 Cited by PubMed: 25169980DOI: 10.1158/1535-7163.MCT-14-0248 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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