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5B7V

Human FGFR1 kinase in complex with CH5183284

Replaces:  3WJ6
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Fibroblast growth factor receptor 1polymer31035308.62UniProt (P11362)
Pfam (PF07714)
Homo sapiens (Human)
2C, E
(A, B)
[5-amino-1-(2-methyl-1H-benzimidazol-6-yl)-1H-pyrazol-4-yl](1H-indol-2-yl)methanonenon-polymer356.42Chemie (LWJ)
3D
(A)
SULFATE IONnon-polymer96.11Chemie (SO4)
4F, G
(A, B)
waterwater18.075Chemie (HOH)
Sequence modifications
A, B: 456 - 765 (UniProt: P11362)
PDBExternal DatabaseDetails
Val 457Leu 457engineered mutation
Ala 488Cys 488engineered mutation
Ser 584Cys 584engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight70617.2
Non-Polymers*Number of molecules3
Total formula weight808.8
All*Total formula weight71426.1
*Water molecules are not included.

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PDB entries from 2024-10-30

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