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5XS2

CDK8-CYCC IN COMPLEX WITH COMPOUND 17:3-chloro-4-(4-pyridyl)-1H-pyrrole-2-carboxamide

Summary for 5XS2
Entry DOI10.2210/pdb5xs2/pdb
DescriptorCyclin-dependent kinase 8, Cyclin-C, GLYCEROL, ... (5 entities in total)
Functional Keywordscdk8, cyclin c, mediator complex, transferase
Biological sourceHomo sapiens (Human)
More
Cellular locationNucleus : P49336 P24863
Total number of polymer chains2
Total formula weight75796.50
Authors
Zhou, Z.,Xu, Z. (deposition date: 2017-06-12, release date: 2017-08-09, Last modification date: 2024-03-27)
Primary citationHan, X.,Jiang, M.,Zhou, C.,Zhou, Z.,Xu, Z.,Wang, L.,Mayweg, A.V.,Niu, R.,Jin, T.G.,Yang, S.
Discovery of potent and selective CDK8 inhibitors through FBDD approach
Bioorg. Med. Chem. Lett., 27:4488-4492, 2017
Cited by
PubMed: 28802632
DOI: 10.1016/j.bmcl.2017.07.080
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.04 Å)
Structure validation

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