PDB: 1384 件ウェブページステータス検索Chemie searchBIRD

---

6IBR	Crystal structure of human alpha-galactosidase A in complex with alpha-galactose configured cyclophellitol epoxide LWA481 分子名称: (2~{R},3~{S},4~{S},5~{R},6~{S})-5-(hydroxymethyl)-7-oxabicyclo[4.1.0]heptane-2,3,4-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Rowland, R.J, Wu, L, Davies, G.J. 登録日 2018-11-30 公開日 2019-10-09 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Alpha-d-Gal-cyclophellitol cyclosulfamidate is a Michaelis complex analog that stabilizes therapeutic lysosomal alpha-galactosidase A in Fabry disease Chem Sci, 2019
6IBT	Crystal structure of human alpha-galactosidase A in complex with alpha-galactose configured cyclophellitol aziridine ME737 分子名称: (1~{S},2~{S},3~{S},4~{S},5~{R},6~{S})-5-(hydroxymethyl)-7-azabicyclo[4.1.0]heptane-2,3,4-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Rowland, R.J, Wu, L, Davies, G.J. 登録日 2018-11-30 公開日 2019-10-09 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Alpha-d-Gal-cyclophellitol cyclosulfamidate is a Michaelis complex analog that stabilizes therapeutic lysosomal alpha-galactosidase A in Fabry disease Chem Sci, 2019
4J9Y	Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant 分子名称: CALCIUM ION, Calmodulin, GLYCEROL, ... 著者 Zhang, M, Pascal, J.M, Zhang, J.-F. 登録日 2013-02-17 公開日 2013-03-27 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.51 Å) 主引用文献 Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation. Proc.Natl.Acad.Sci.USA, 110, 2013
8EOB	Cryo-EM structure of human HSP90B in the closed state 分子名称: Heat shock protein HSP 90-beta, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Srivastava, D, Artemyev, N.O. 登録日 2022-10-02 公開日 2023-01-25 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Unique interface and dynamics of the complex of HSP90 with a specialized cochaperone AIPL1. Structure, 31, 2023
8EOA	Cryo-EM structure of human HSP90B-AIPL1 complex 分子名称: Aryl-hydrocarbon-interacting protein-like 1, Heat shock protein HSP 90-beta, MAGNESIUM ION, ... 著者 Srivastava, D, Artemyev, N.O. 登録日 2022-10-02 公開日 2023-01-25 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Unique interface and dynamics of the complex of HSP90 with a specialized cochaperone AIPL1. Structure, 31, 2023
7ZUB	Cryo-EM structure of the indirubin-bound Hsp90-XAP2-AHR complex 分子名称: (3~{Z})-3-(3-oxidanylidene-1~{H}-indol-2-ylidene)-1~{H}-indol-2-one, ADENOSINE-5'-DIPHOSPHATE, AH receptor-interacting protein, ... 著者 Gruszczyk, J, Savva, C.G, Lai-Kee-Him, J, Bous, J, Ancelin, A, Kwong, H.S, Grandvuillemin, L, Bourguet, W. 登録日 2022-05-12 公開日 2022-11-23 最終更新日 2022-12-07 実験手法 ELECTRON MICROSCOPY (2.85 Å) 主引用文献 Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex. Nat Commun, 13, 2022
4HEX	A novel conformation of calmodulin 分子名称: CALCIUM ION, Calmodulin, ZINC ION 著者 Kumar, V, Chichili, V.P.R, Sivaraman, J. 登録日 2012-10-04 公開日 2013-03-06 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.001 Å) 主引用文献 A novel trans conformation of ligand-free calmodulin Plos One, 8, 2013
4IL1	Crystal Structure of the Rat Calcineurin 分子名称: CALCIUM ION, Calmodulin, Calcineurin subunit B type 1, ... 著者 Ye, Q, Faucher, F, Jia, Z. 登録日 2012-12-28 公開日 2013-10-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis of calcineurin activation by calmodulin. Cell Signal, 25, 2013
4J9Z	Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and NS309 分子名称: (3E)-6,7-dichloro-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-one, CALCIUM ION, Calmodulin, ... 著者 Zhang, M, Pascal, J.M, Zhang, J.-F. 登録日 2013-02-17 公開日 2013-03-27 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 Unstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activation. Proc.Natl.Acad.Sci.USA, 110, 2013
4GTQ	FTase in complex with BMS analogue 12 分子名称: 4-({(3R)-7-cyano-4-[(4-methoxyphenyl)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl}methyl)phenyl benzylcarbamate, FARNESYL DIPHOSPHATE, Protein farnesyltransferase subunit beta, ... 著者 Guo, Z, Stigter, E.A, Bon, R.S, Waldmann, H, Blankenfeldt, W, Goody, R.S. 登録日 2012-08-29 公開日 2012-10-24 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Development of Selective, Potent RabGGTase Inhibitors J.Med.Chem., 55, 2012
2DFS	3-D structure of Myosin-V inhibited state 分子名称: Calmodulin, Myosin-5A 著者 Liu, J, Taylor, D.W, Krementsova, E.B, Trybus, K.M, Taylor, K.A. 登録日 2006-03-03 公開日 2006-04-25 最終更新日 2024-03-13 実験手法 ELECTRON CRYSTALLOGRAPHY (24 Å) 主引用文献 Three-dimensional structure of the myosin V inhibited state by cryoelectron tomography Nature, 442, 2006
8X1C	Structure of nucleosome-bound SRCAP-C in the ADP-bound state 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... 著者 Yu, J, Wang, Q, Yu, Z, Li, W, Wang, L, Xu, Y. 登録日 2023-11-06 公開日 2024-03-06 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural insights into histone exchange by human SRCAP complex. Cell Discov, 10, 2024
8X19	Structure of nucleosome-bound SRCAP-C in the ADP-BeFx-bound state 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... 著者 Yu, J, Wang, Q, Yu, Z, Li, W, Wang, L, Xu, Y. 登録日 2023-11-06 公開日 2024-03-06 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural insights into histone exchange by human SRCAP complex. Cell Discov, 10, 2024
8VSP	Cryo-EM structure of human invariant chain in complex with HLA-DQ 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II histocompatibility antigen gamma chain, HLA class II histocompatibility antigen, ... 著者 Wang, N, Caveney, N.A, Jude, K.M, Garcia, K.C. 登録日 2024-01-24 公開日 2024-05-08 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.12 Å) 主引用文献 Structural insights into human MHC-II association with invariant chain. Proc.Natl.Acad.Sci.USA, 121, 2024
8VRW	Cryo-EM structure of human invariant chain in complex with HLA-DR15 分子名称: HLA class II histocompatibility antigen gamma chain, HLA class II histocompatibility antigen, DR alpha chain, ... 著者 Wang, N, Caveney, N.A, Jude, K.M, Garcia, K.C. 登録日 2024-01-22 公開日 2024-05-08 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.03 Å) 主引用文献 Structural insights into human MHC-II association with invariant chain. Proc.Natl.Acad.Sci.USA, 121, 2024
8X15	Structure of nucleosome-bound SRCAP-C in the apo state 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... 著者 Yu, J, Wang, Q, Yu, Z, Li, W, Wang, L, Xu, Y. 登録日 2023-11-06 公開日 2024-03-06 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural insights into histone exchange by human SRCAP complex. Cell Discov, 10, 2024
3E32	Protein farnesyltransferase complexed with FPP and ethylenediamine scaffold inhibitor 2 分子名称: FARNESYL DIPHOSPHATE, N-benzyl-N-(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino}ethyl)-1-methyl-1H-imidazole-4-sulfonamide, Protein farnesyltransferase subunit beta, ... 著者 Hast, M.A, Beese, L.S. 登録日 2008-08-06 公開日 2009-03-10 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase. Chem.Biol., 16, 2009
3EUV	Crystal structure of FTase(ALPHA-subunit; BETA-subunit DELTA C10, W102T, Y154T) in complex with BiotinGPP 分子名称: (2E,6E)-3,7-dimethyl-8-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)octa-2,6-dien-1-yl trihydrogen diphosphate, Protein farnesyltransferase subunit beta, Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, ... 著者 Guo, Z, Nguyen, U.T.T, Delon, C, Bon, R.S, Blankenfeldt, W, Goody, R.S, Waldmann, H, Wolters, D, Alexandrov, K. 登録日 2008-10-11 公開日 2009-07-07 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Analysis of the eukaryotic prenylome by isoprenoid affinity tagging Nat.Chem.Biol., 5, 2009
3E34	Protein farnesyltransferase complexed with FPP and ethylenediamine-scaffold inhibitor 10 分子名称: 3-{2'-[{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino}ethyl)sulfamoyl]biphenyl-3-yl}propanoic acid, FARNESYL DIPHOSPHATE, Protein farnesyltransferase subunit beta, ... 著者 Hast, M.A, Beese, L.S. 登録日 2008-08-06 公開日 2009-03-10 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase. Chem.Biol., 16, 2009
3EU5	Crystal structure of FTase(ALPHA-subunit; BETA-subunit DELTA C10) in complex with BiotinGPP 分子名称: (2E,6E)-3,7-dimethyl-8-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)octa-2,6-dien-1-yl trihydrogen diphosphate, Protein farnesyltransferase subunit beta, Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, ... 著者 Guo, Z, Nguyen, U.T.T, Delon, C, Bon, R.S, Blankenfeldt, W, Goody, R.S, Waldmann, H, Wolters, D, Alexandrov, K. 登録日 2008-10-09 公開日 2009-07-07 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Analysis of the eukaryotic prenylome by isoprenoid affinity tagging Nat.Chem.Biol., 5, 2009
3E30	Protein farnesyltransferase complexed with FPP and ethylene diamine inhibitor 4 分子名称: FARNESYL DIPHOSPHATE, Protein farnesyltransferase subunit beta, Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, ... 著者 Hast, M.A, Beese, L.S. 登録日 2008-08-06 公開日 2009-03-10 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase. Chem.Biol., 16, 2009
1FG9	3:1 COMPLEX OF INTERFERON-GAMMA RECEPTOR WITH INTERFERON-GAMMA DIMER 分子名称: INTERFERON GAMMA, INTERFERON-GAMMA RECEPTOR ALPHA CHAIN 著者 Thiel, D.J, le Du, M.-H, Walter, R.L, D'Arcy, A, Chene, C, Fountoulakis, M, Garotta, G, Winkler, F.K, Ealick, S.E. 登録日 2000-07-28 公開日 2000-08-11 最終更新日 2022-12-21 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex. Structure Fold.Des., 8, 2000
1FYH	1:1 COMPLEX BETWEEN AN INTERFERON GAMMA SINGLE-CHAIN VARIANT AND ITS RECEPTOR 分子名称: CHLORIDE ION, Interferon gamma, Interferon gamma receptor 1 著者 Randal, M, Kossiakoff, A.A. 登録日 2000-09-29 公開日 2000-10-11 最終更新日 2017-06-21 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 The structure and activity of a monomeric interferon-gamma:alpha-chain receptor signaling complex. Structure, 9, 2001
3E33	Protein farnesyltransferase complexed with FPP and ethylenediamine scaffold inhibitor 7 分子名称: FARNESYL DIPHOSPHATE, N-benzyl-N-(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino}ethyl)-2-methylbenzenesulfonamide, Protein farnesyltransferase subunit beta, ... 著者 Hast, M.A, Beese, L.S. 登録日 2008-08-06 公開日 2009-03-10 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase. Chem.Biol., 16, 2009
3DPY	Protein farnesyltransferase complexed with FPP and caged TKCVIM substrate 分子名称: ACETIC ACID, FARNESYL DIPHOSPHATE, Protein farnesyltransferase subunit beta, ... 著者 Hast, M.A, Beese, L.S. 登録日 2008-07-09 公開日 2008-09-30 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Caged protein prenyltransferase substrates: tools for understanding protein prenylation. Chem.Biol.Drug Des., 72, 2008

<33343536373839404142434445464748>