3E33

Protein farnesyltransferase complexed with FPP and ethylenediamine scaffold inhibitor 7

Summary for 3E33

Entry DOI	10.2210/pdb3e33/pdb
Related	1D8D 1KZO 1KZP 1SA4 1SA5 2IEJ 3E30 3E32 3E34 3E37
Descriptor	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, Protein farnesyltransferase subunit beta, ZINC ION, ... (6 entities in total)
Functional Keywords	ftase, protein farnesyltransferase, farnesyltransferase, malaria, plasmodium, falciparum, antimalarial, inhibitor, ethylenediamine, prenyltransferase, transferase, metal-binding, phosphoprotein, zinc
Biological source	Rattus norvegicus (rat) More
Total number of polymer chains	2
Total formula weight	93767.79
Authors	Hast, M.A.,Beese, L.S. (deposition date: 2008-08-06, release date: 2009-03-10, Last modification date: 2024-02-21)
Primary citation	Hast, M.A.,Fletcher, S.,Cummings, C.G.,Pusateri, E.E.,Blaskovich, M.A.,Rivas, K.,Gelb, M.H.,Van Voorhis, W.C.,Sebti, S.M.,Hamilton, A.D.,Beese, L.S. Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase. Chem.Biol., 16:181-192, 2009 Cited by PubMed: 19246009 DOI: 10.1016/j.chembiol.2009.01.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation