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5ACQ
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W228A-Investigation of the impact from residues W228 and Y233 in the metallo-beta-lactamase GIM-1
分子名称: BETA-LACTAMASE, ZINC ION
著者Skagseth, S, Carlsen, T.J, Bjerga, G.E.K, Spencer, J, Samuelsen, O, Leiros, H.-K.S.
登録日2015-08-17
公開日2015-12-23
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Role of Residues W228 and Y233 in the Structure and Activity of Metallo-Beta-Lactamase Gim-1.
Antimicrob.Agents Chemother., 60, 2015
5A87
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Crystal structure of the metallo-beta-lactamase VIM-5
分子名称: GLYCEROL, METALLO-BETA-LACTAMASE VIM-5, ZINC ION
著者Brem, J, Duzgun, A.O, McDonough, M.A, Schofield, C.J.
登録日2015-07-13
公開日2015-12-23
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Comparison of Verona Integron-Borne Metallo-beta-Lactamase (VIM) Variants Reveals Differences in Stability and Inhibition Profiles.
Antimicrob. Agents Chemother., 60, 2015
5ACT
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BU of 5act by Molmil
W228S-Investigation of the impact from residues W228 and Y233 in the metallo-beta-lactamase GIM-1
分子名称: GIM-1 PROTEIN, ZINC ION
著者Skagseth, S, Carlsen, T.J, Bjerga, G.E.K, Spencer, J, Samuelsen, O, Leiros, H.-K.S.
登録日2015-08-17
公開日2015-12-23
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Role of Residues W228 and Y233 in the Structure and Activity of Metallo-Beta-Lactamase Gim-1.
Antimicrob.Agents Chemother., 60, 2015
8R5U
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BU of 8r5u by Molmil
VIM-2 metallo-beta-lactamase in complex with benzebisheterocycle compound 14
分子名称: Beta-lactamase VIM-2, FORMIC ACID, ZINC ION, ...
著者Hinchliffe, P, Spencer, J.
登録日2023-11-17
公開日2024-04-10
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Rational Design of Benzobisheterocycle Metallo-beta-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes.
J.Med.Chem., 67, 2024
8R5T
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BU of 8r5t by Molmil
Crystal structure of NDM-1 in complex with benzobisheterocycle compound 14.
分子名称: Metallo-beta-lactamase type 2, SULFATE ION, ZINC ION, ...
著者Hinchliffe, P, Spencer, J.
登録日2023-11-17
公開日2024-04-10
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Rational Design of Benzobisheterocycle Metallo-beta-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes.
J.Med.Chem., 67, 2024
8SK2
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BU of 8sk2 by Molmil
X-ray structure of the NDM-4 beta-lactamase from Klebsiella pneumonia, apo form
分子名称: 1,2-ETHANEDIOL, Metallo-beta-lactamase type 2, ZINC ION
著者Thoden, J.B, Holden, H.M.
登録日2023-04-18
公開日2023-08-23
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Characterization of a novel inhibitor for the New Delhi metallo-beta-lactamase-4: Implications for drug design and combating bacterial drug resistance.
J.Biol.Chem., 299, 2023
4NQ6
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Bacillus cereus Zn-dependent metallo-beta-lactamase at pH 7 complexed with compound L-CS319
分子名称: (3S,5S,7aR)-5-(sulfanylmethyl)tetrahydro[1,3]thiazolo[4,3-b][1,3]thiazole-3-carboxylic acid, Beta-lactamase 2, POTASSIUM ION, ...
著者Gonzalez, J.M, Gonzalez, M.M, Vila, A.J.
登録日2013-11-23
公開日2014-11-26
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Cross-class metallo-beta-lactamase inhibition by bisthiazolidines reveals multiple binding modes.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
4LE6
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BU of 4le6 by Molmil
Crystal structure of the phosphotriesterase OPHC2 from Pseudomonas pseudoalcaligenes
分子名称: 1,2-ETHANEDIOL, GLYCEROL, Organophosphorus hydrolase, ...
著者Gotthard, G, Hiblot, J, Chabriere, E, Elias, M.
登録日2013-06-25
公開日2013-11-13
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural and Enzymatic Characterization of the Phosphotriesterase OPHC2 from Pseudomonas pseudoalcaligenes.
Plos One, 8, 2013
8SKP
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BU of 8skp by Molmil
X-ray structure of the NDM-4 beta-lactamase from Klebsiella pneumonia in complex with 1-hydroxypyridine-2(1H)-thione-6-carboxylic acid
分子名称: 1,2-ETHANEDIOL, 1-hydroxy-6-sulfanylidene-1,6-dihydropyridine-2-carboxylic acid, Metallo-beta-lactamase type 2, ...
著者Thoden, J.B, Holden, H.M.
登録日2023-04-20
公開日2023-08-23
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Characterization of a novel inhibitor for the New Delhi metallo-beta-lactamase-4: Implications for drug design and combating bacterial drug resistance.
J.Biol.Chem., 299, 2023
8SKO
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BU of 8sko by Molmil
X-ray structure of the NDM-4 beta-lactamase from Klebsiella pneumonia with L-Captopril bound
分子名称: L-CAPTOPRIL, Metallo-beta-lactamase type 2, ZINC ION
著者Thoden, J.B, Holden, H.M.
登録日2023-04-20
公開日2023-08-23
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Characterization of a novel inhibitor for the New Delhi metallo-beta-lactamase-4: Implications for drug design and combating bacterial drug resistance.
J.Biol.Chem., 299, 2023
4NQ4
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BU of 4nq4 by Molmil
Bacillus cereus Zn-dependent metallo-beta-lactamase at pH 7
分子名称: Beta-lactamase 2, POTASSIUM ION, ZINC ION
著者Gonzalez, J.M, Gonzalez, M.M, Vila, A.J.
登録日2013-11-23
公開日2014-11-26
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Inhibition of metallo-lactamases with bicyclic compounds
TO BE PUBLISHED
8U00
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BU of 8u00 by Molmil
Crystal structure of metallo-beta-lactamase superfamily protein from Caulobacter vibrioides
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ...
著者Kim, Y, Maltseva, N, Endres, M, Joachimiak, A, Center for Structural Biology of Infectious Diseases (CSBID)
登録日2023-08-28
公開日2023-09-27
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal structure of metallo-beta-lactamase superfamily protein from Caulobacter vibrioides
To Be Published
4O98
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BU of 4o98 by Molmil
Crystal structure of Pseudomonas oleovorans PoOPH mutant H250I/I263W
分子名称: ZINC ION, organophosphorus hydrolase
著者Luo, X.J, Kong, X.D, Zhao, J, Chen, Q, Zhou, J.H, Xu, J.H.
登録日2014-01-02
公開日2014-12-03
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.251 Å)
主引用文献Switching a newly discovered lactonase into an efficient and thermostable phosphotriesterase by simple double mutations His250Ile/Ile263Trp
Biotechnol.Bioeng., 111, 2014
4P62
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Directed evolution of a B3 metallo-beta-lactamase AIM-1
分子名称: 1,2-ETHANEDIOL, Metallo-beta-lactamase AIM-1, ZINC ION
著者Hou, C.-F.D, Collyer, C, Ollis, D.L.
登録日2014-03-21
公開日2015-05-27
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Directed evolution of a B3 metallo-beta-lactamase AIM-1
To Be Published
4NQ5
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BU of 4nq5 by Molmil
Bacillus cereus Zn-dependent metallo-beta-lactamase at pH 7 complexed with compound CS319
分子名称: (3R,5R,7aS)-5-(sulfanylmethyl)tetrahydro[1,3]thiazolo[4,3-b][1,3]thiazole-3-carboxylic acid, Beta-lactamase 2, POTASSIUM ION, ...
著者Gonzalez, J.M, Gonzalez, M.M, Vila, A.J.
登録日2013-11-23
公開日2014-11-26
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Inhibition of metallo-lactamases with bicyclic compounds
TO BE PUBLISHED
4NQ2
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Structure of Zn(II)-bound metallo-beta-lactamse VIM-2 from Pseudomonas aeruginosa
分子名称: ACETATE ION, Beta-lactamase class B VIM-2, ZINC ION
著者Aitha, M, Nix, J.C, Crowder, M.W, Page, R.C.
登録日2013-11-23
公開日2014-11-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Biochemical, Mechanistic, and Spectroscopic Characterization of Metallo-beta-lactamase VIM-2.
Biochemistry, 53, 2014
2WRS
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BU of 2wrs by Molmil
Crystal Structure of the Mono-Zinc Metallo-beta-lactamase VIM-4 from Pseudomonas aeruginosa
分子名称: BETA-LACTAMASE VIM-4, CITRATE ANION, CITRIC ACID, ...
著者Lassaux, P, Hamel, M, Gulea, M, Delbruck, H, Traore, D.A.K, Mercuri, P.S, Horsfall, L, Dehareng, D, Gaumont, A.-C, Frere, J.-M, Ferrer, J.-L, Hoffmann, K, Galleni, M, Bebrone, C.
登録日2009-09-02
公開日2010-06-23
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献Mercaptophosphonate Compounds as Broad-Spectrum Inhibitors of the Metallo-Beta-Lactamases.
J.Med.Chem., 53, 2010
4XUK
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BU of 4xuk by Molmil
Crystal structure of hydrolase AbOPH in beta lactamase superfamily
分子名称: Putative hydrolase, ZINC ION
著者Chen, J, Xu, J.H, Zhou, J.H.
登録日2015-01-26
公開日2015-10-21
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Marked enhancement of Acinetobacter sp. organophosphorus hydrolase activity by a single residue substitution Ile211Ala
Bioresour Bioprocess, 2015
3ESH
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BU of 3esh by Molmil
Crystal structure of a probable metal-dependent hydrolase from Staphylococcus aureus. Northeast Structural Genomics target ZR314
分子名称: Protein similar to metal-dependent hydrolase
著者Seetharaman, J, Chen, Y, Wang, H, Janjua, H, Foote, E.L, Xiao, R, Nair, R, Everett, J.K, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG)
登録日2008-10-06
公開日2008-10-28
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of a probable metal-dependent hydrolase from Staphylococcus aureus. Northeast Structural Genomics target ZR314
To be Published
2UYX
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BU of 2uyx by Molmil
metallo-beta-lactamase (1BC2) single point mutant D120S
分子名称: BETA-LACTAMASE II, GLYCEROL, ZINC ION
著者Larrull, L.I, Fabiane, S.M, Kowalski, J.M, Bennett, B, Sutton, B.J, Vila, A.J.
登録日2007-04-20
公開日2007-05-08
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Asp-120 locates Zn2 for optimal metallo-beta-lactamase activity.
J. Biol. Chem., 282, 2007
2VW8
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BU of 2vw8 by Molmil
Crystal Structure of Quinolone signal response protein pqsE from Pseudomonas aeruginosa
分子名称: 1,2-ETHANEDIOL, CACODYLATE ION, FE (II) ION, ...
著者Carter, L.G, Johnson, K.A, Liu, H, Mcmahon, S.A, Oke, M, Naismith, J.H, White, M.F.
登録日2008-06-17
公開日2010-07-14
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献The Scottish Structural Proteomics Facility: Targets, Methods and Outputs.
J.Struct.Funct.Genomics, 11, 2010
3F9O
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BU of 3f9o by Molmil
Crystal Structure of the Di-Zinc Carbapenemase CphA from Aeromonas Hydrophila
分子名称: Beta-lactamase, CARBONATE ION, CHLORIDE ION, ...
著者Delbruck, H, Hoffmann, K.M.V.
登録日2008-11-14
公開日2009-09-01
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献The structure of the dizinc subclass B2 metallo-beta-lactamase CphA reveals that the second inhibitory zinc ion binds in the histidine site
Antimicrob.Agents Chemother., 53, 2009
1KO3
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BU of 1ko3 by Molmil
VIM-2, a Zn-beta-lactamase from Pseudomonas aeruginosa with Cys221 reduced
分子名称: ACETATE ION, CHLORIDE ION, HYDROXIDE ION, ...
著者Garcia-Saez, I, Docquier, J.-D, Rossolini, G.M, Dideberg, O.
登録日2001-12-20
公開日2003-09-02
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献The three-dimensional structure of VIM-2, a Zn-beta-lactamase from Pseudomonas aeruginosa in its reduced and oxidised form
J.Mol.Biol., 375, 2008
3FAI
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BU of 3fai by Molmil
The Di Zinc Carbapenemase CphA N220G mutant
分子名称: Beta-lactamase, CHLORIDE ION, GLYCEROL, ...
著者Delbruck, H, Hoffmann, K.M.V.
登録日2008-11-17
公開日2009-09-01
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The structure of the dizinc subclass B2 metallo-beta-lactamase CphA reveals that the second inhibitory zinc ion binds in the histidine site
Antimicrob.Agents Chemother., 53, 2009
3DH8
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BU of 3dh8 by Molmil
Structure of Pseudomonas Quinolone Signal Response Protein PqsE
分子名称: FE (III) ION, Uncharacterized protein PA1000, bis(4-nitrophenyl) hydrogen phosphate
著者Yu, S, Blankenfeldt, W.
登録日2008-06-17
公開日2009-06-23
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure elucidation and preliminary assessment of hydrolase activity of PqsE, the Pseudomonas quinolone signal (PQS) response protein.
Biochemistry, 48, 2009

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件を2024-07-17に公開中

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