8OSM
| GTPASE HRAS IN COMPLEX WITH ZN-CYCLEN AT 200 MPA PRESSURE | 分子名称: | GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | 著者 | Colloc'h, N, Girard, E, Prange, T, Kalbitzer, H.R. | 登録日 | 2023-04-19 | 公開日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | High pressure promotes binding of the allosteric inhibitor Zn2+-cyclen in crystals of activated H-Ras. Chemistry, 2024
|
|
8IJ9
| Crystal structure of the ELKS1/Rab6B complex | 分子名称: | ELKS/Rab6-interacting/CAST family member 1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Jin, G, Wei, Z. | 登録日 | 2023-02-26 | 公開日 | 2023-06-14 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Structural basis of ELKS/Rab6B interaction and its role in vesicle capturing enhanced by liquid-liquid phase separation. J.Biol.Chem., 299, 2023
|
|
421P
| THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES | 分子名称: | H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 著者 | Krengel, U, John, J, Scherer, A, Kabsch, W, Wittinghofer, A, Pai, E.F. | 登録日 | 1991-06-06 | 公開日 | 1994-01-31 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules. Cell(Cambridge,Mass.), 62, 1990
|
|
3X1Y
| Ras-related protein Rap1B(L9V) with GppNHp | 分子名称: | CADMIUM ION, GLYCEROL, MAGNESIUM ION, ... | 著者 | Noguchi, H, Ikegami, T, Park, S.Y, Tame, J.R.H, Unzai, S. | 登録日 | 2014-12-02 | 公開日 | 2015-06-03 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.168 Å) | 主引用文献 | The structure and conformational switching of Rap1B Biochem.Biophys.Res.Commun., 462, 2015
|
|
3X1W
| Ras-related protein Rap1B with GDP | 分子名称: | CADMIUM ION, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Noguchi, H, Ikegami, T, Akashi, S, Park, S.Y, Tame, J.R.H, Unzai, S. | 登録日 | 2014-12-02 | 公開日 | 2015-06-03 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | The structure and conformational switching of Rap1B Biochem.Biophys.Res.Commun., 462, 2015
|
|
4AII
| Crystal structure of the rat REM2 GTPase - G domain bound to GDP | 分子名称: | GTP-BINDING PROTEIN REM 2, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | 著者 | Reymond, P, Coquard, A, Chenon, M, Zeghouf, M, El Marjou, A, Thompson, A, Menetrey, J. | 登録日 | 2012-02-10 | 公開日 | 2012-06-13 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.66 Å) | 主引用文献 | Structure of the Gdp-Bound G Domain of the Rgk Protein Rem2. Acta Crystallogr.,Sect.F, 68, 2012
|
|
3X1X
| Ras-related protein Rap1B with GppNHp | 分子名称: | CADMIUM ION, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | 著者 | Noguchi, H, Ikegami, T, Park, S.Y, Tame, J.R.H, Unzai, S. | 登録日 | 2014-12-02 | 公開日 | 2015-06-03 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1 Å) | 主引用文献 | The structure and conformational switching of Rap1B Biochem.Biophys.Res.Commun., 462, 2015
|
|
3X1Z
| Ras-related protein Rap1B(T65A) with GppNHp | 分子名称: | GLYCEROL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | 著者 | Noguchi, H, Ikegami, T, Park, S.Y, Tame, J.R.H, Unzai, S. | 登録日 | 2014-12-02 | 公開日 | 2015-06-03 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | The structure and conformational switching of Rap1B Biochem.Biophys.Res.Commun., 462, 2015
|
|
3V4F
| H-Ras PEG 400/CaCl2, ordered off | 分子名称: | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, CALCIUM ION, GTPase HRas, ... | 著者 | Holzapfel, G, Mattos, C. | 登録日 | 2011-12-14 | 公開日 | 2012-08-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.391 Å) | 主引用文献 | Shift in the Equilibrium between On and Off States of the Allosteric Switch in Ras-GppNHp Affected by Small Molecules and Bulk Solvent Composition. Biochemistry, 51, 2012
|
|
7WZA
| An open conformation Form 1 of switch II for RhoA | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Transforming protein RhoA | 著者 | Jiang, H, Luo, C. | 登録日 | 2022-02-17 | 公開日 | 2023-02-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.50028777 Å) | 主引用文献 | A RhoA structure with switch II flipped outward revealed the conformational dynamics of switch II region. J.Struct.Biol., 215, 2023
|
|
7WZC
| |
7XKJ
| Kras-G12D-GDP-MRTX1133 by FIB-MicroED | 分子名称: | 4-(4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2R,4R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol, GUANOSINE-5'-DIPHOSPHATE, KRAS proto-oncogene, ... | 著者 | Li, X.M. | 登録日 | 2022-04-19 | 公開日 | 2023-08-02 | 最終更新日 | 2023-08-16 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (3 Å) | 主引用文献 | Kras-G12D-GDP-MRTX1133 by FIB-MicroED To Be Published
|
|
7YCE
| KRas G12C in complex with Compound 7b | 分子名称: | 1-[7-[6-chloranyl-2-(1-ethylpiperidin-4-yl)oxy-8-fluoranyl-7-(5-methyl-1~{H}-indazol-4-yl)quinazolin-4-yl]-2,7-diazaspiro[3.5]nonan-2-yl]propan-1-one, GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ... | 著者 | Amano, Y. | 登録日 | 2022-07-01 | 公開日 | 2022-08-10 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Discovery and biological evaluation of 1-{2,7-diazaspiro[3.5]nonan-2-yl}prop-2-en-1-one derivatives as covalent inhibitors of KRAS G12C with favorable metabolic stability and anti-tumor activity. Bioorg.Med.Chem., 71, 2022
|
|
7YCC
| KRas G12C in complex with Compound 5c | 分子名称: | 1-[7-[6-chloranyl-8-fluoranyl-7-(5-methyl-1~{H}-indazol-4-yl)-2-[(1-methylpiperidin-4-yl)amino]quinazolin-4-yl]-2,7-diazaspiro[3.5]nonan-2-yl]propan-1-one, GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ... | 著者 | Amano, Y. | 登録日 | 2022-07-01 | 公開日 | 2022-08-10 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Discovery and biological evaluation of 1-{2,7-diazaspiro[3.5]nonan-2-yl}prop-2-en-1-one derivatives as covalent inhibitors of KRAS G12C with favorable metabolic stability and anti-tumor activity. Bioorg.Med.Chem., 71, 2022
|
|
7XQV
| The complex of nanobody Rh57 binding to GTP-bound RhoA active form | 分子名称: | ALANINE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | 著者 | Zhang, Y.R, Liu, R, Ding, Y. | 登録日 | 2022-05-09 | 公開日 | 2022-07-13 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | 主引用文献 | Structural insights into the binding of nanobody Rh57 to active RhoA-GTP. Biochem.Biophys.Res.Commun., 616, 2022
|
|
7VV9
| |
7VVG
| |
7VV8
| |
7Y4A
| Crystal structure of human ELMO1 RBD-RhoG complex | 分子名称: | Engulfment and cell motility protein 1, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Tsuda, K, Kukimoto-Niino, M, Shirouzu, M. | 登録日 | 2022-06-14 | 公開日 | 2023-03-15 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Targeting Ras-binding domain of ELMO1 by computational nanobody design. Commun Biol, 6, 2023
|
|
7W5R
| KRAS G12V and peptide complex | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, LEU-TYR-ASP-VAL-ALA, ... | 著者 | Kim, H.J, Han, C.W, Jang, S.B. | 登録日 | 2021-11-30 | 公開日 | 2022-12-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.87 Å) | 主引用文献 | Structural basis of the oncogenic KRAS mutant and GJ101 complex. Biochem.Biophys.Res.Commun., 641, 2023
|
|
6JIK
| |
6IY1
| |
6H46
| Human KRAS in complex with darpin K13 | 分子名称: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION, ... | 著者 | Debreczeni, J.E, Bery, N, Legg, S, Breed, J, Embrey, K, Stubbs, C, Kolasinska-Zwierz, P, Barrett, N, Marwood, R, Watson, J, Tart, J, Overman, R, Miller, A, Phillips, C, Minter, R, Rabbitts, T.H. | 登録日 | 2018-07-20 | 公開日 | 2019-04-24 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe. Nat Commun, 10, 2019
|
|
6HXU
| Crystal structure of Human RHOB Q63L in complex with GTP | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Rho-related GTP-binding protein RhoB | 著者 | Soulie, S, Gence, R, Cabantous, S, Lajoie-Mazenc, I, Favre, G, Pedelacq, J.D. | 登録日 | 2018-10-18 | 公開日 | 2019-09-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.19 Å) | 主引用文献 | A Targeted Protein Degradation Cell-Based Screening for Nanobodies Selective toward the Cellular RHOB GTP-Bound Conformation. Cell Chem Biol, 26, 2019
|
|
6HDU
| |