PDB: 1359 件ウェブページステータス検索Chemie searchBIRD

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8JHL	GDP-bound KRAS G12D in complex with YK-8S 分子名称: 1-[4-[7-(8-ethynyl-7-fluoranyl-naphthalen-1-yl)-8-fluoranyl-2-[[(2~{R},8~{S})-2-fluoranyl-1,2,3,5,6,7-hexahydropyrrolizin-8-yl]methoxy]pyrido[4,3-d]pyrimidin-4-yl]piperazin-1-yl]-3-oxidanyl-propan-1-one, GTPase KRas, N-terminally processed, ... 著者 Zhang, Z.M, Wang, R.L. 登録日 2023-05-23 公開日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.10004044 Å) 主引用文献 Simultaneous Covalent Modification of K-Ras(G12D) and K-Ras(G12C) with Tunable Oxirane Electrophiles. J.Am.Chem.Soc., 145, 2023
3GJ0	Crystal structure of human RanGDP 分子名称: GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Partridge, J.R, Schwartz, T.U. 登録日 2009-03-07 公開日 2009-08-04 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Crystallographic and Biochemical Analysis of the Ran-binding Zinc Finger Domain. J.Mol.Biol., 391, 2009
8JQU	Crystal structure of GppNHp bound GTPase domain of Rab5a from Leishmania donovani 分子名称: 1,2-ETHANEDIOL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Pandey, D, Zohib, M, Pal, R.K, Biswal, B.K, Arora, A. 登録日 2023-06-14 公開日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.798 Å) 主引用文献 Crystal structure of GppNHp bound GTPase domain of Rab5a from Leishmania donovani To Be Published
3I3S	Crystal Structure of H-Ras with Thr50 replaced by Isoleucine 分子名称: CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... 著者 Gremer, L, Dvorsky, R, Merbitz-Zahradnik, T, Wittinghofer, A, Ahmadian, M.R. 登録日 2009-06-30 公開日 2009-12-22 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.36 Å) 主引用文献 A restricted spectrum of NRAS mutations causes Noonan syndrome. Nat.Genet., 42, 2010
3IHW	Crystal structure of the Ras-like domain of CENTG3 分子名称: CENTG3, UNKNOWN ATOM OR ION 著者 Nedyalkova, L, Tempel, W, Tong, Y, Li, Y, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) 登録日 2009-07-30 公開日 2009-08-11 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Crystal structure of the Ras-like domain of CENTG3 to be published
8JJS	Human K-Ras G12D (GDP-bound) in complex with cyclic peptide inhibitor AP10343 分子名称: GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, MAA-ILE-SAR-SAR-7T2-SAR-IAE-LEU-MEA-MLE-7TK, ... 著者 Irie, M, Fukami, T.A, Tanada, M, Ohta, A, Torizawa, T. 登録日 2023-05-31 公開日 2023-07-26 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.534 Å) 主引用文献 Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor. J.Am.Chem.Soc., 145, 2023
8ONV	KRAS-G13D in complex with BI-2493 分子名称: (7~{S})-2'-azanyl-3-[2-[(2~{S})-2-methylpiperazin-1-yl]pyrimidin-4-yl]spiro[5,6-dihydro-4~{H}-1,2-benzoxazole-7,4'-6,7-dihydro-5~{H}-1-benzothiophene]-3'-carbonitrile, 1,2-ETHANEDIOL, GTPase KRas, ... 著者 Boettcher, J, Herdeis, L. 登録日 2023-04-04 公開日 2023-06-07 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.01 Å) 主引用文献 Pan-KRAS inhibitor disables oncogenic signalling and tumour growth. Nature, 619, 2023
8OSN	GTPASE HRAS IN COMPLEX WITH ZN-CYCLEN AT AMBIENT PRESSURE 分子名称: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Colloc'h, N, Prange, T, Girard, E, Kalbitzer, H.R. 登録日 2023-04-19 公開日 2024-05-08 最終更新日 2024-07-03 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 High Pressure Promotes Binding of the Allosteric Inhibitor Zn 2+ -Cyclen in Crystals of Activated H-Ras. Chemistry, 30, 2024
8OSO	GTPase HRAS in complex with Zn-cyclen under 500 MPa pressure 分子名称: 1,4,7,10-tetraazacyclododecane, GTPase HRas, MAGNESIUM ION, ... 著者 Colloc'h, N, Prange, T, Girard, E, Kalbitzer, H.R. 登録日 2023-04-19 公開日 2024-05-08 最終更新日 2024-07-03 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 High Pressure Promotes Binding of the Allosteric Inhibitor Zn 2+ -Cyclen in Crystals of Activated H-Ras. Chemistry, 30, 2024
8OSM	GTPASE HRAS IN COMPLEX WITH ZN-CYCLEN AT 200 MPA PRESSURE 分子名称: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Colloc'h, N, Girard, E, Prange, T, Kalbitzer, H.R. 登録日 2023-04-19 公開日 2024-05-08 最終更新日 2024-07-03 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 High Pressure Promotes Binding of the Allosteric Inhibitor Zn 2+ -Cyclen in Crystals of Activated H-Ras. Chemistry, 30, 2024
3GFT	Human K-Ras (Q61H) in complex with a GTP analogue 分子名称: CITRIC ACID, GTPase KRas, MAGNESIUM ION, ... 著者 Tong, Y, Tempel, W, Shen, L, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) 登録日 2009-02-27 公開日 2009-03-10 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Human K-Ras in complex with a GTP analogue To be Published
4PZZ	Second-site screening of K-Ras in the presence of covalently attached first-site ligands 分子名称: 1H-benzimidazol-2-ylmethanethiol, GUANOSINE-5'-DIPHOSPHATE, K-Ras, ... 著者 Sun, Q, Phan, J, Friberg, A, Camper, D.V, Olejniczak, E.T, Fesik, S.W. 登録日 2014-03-31 公開日 2014-09-10 実験手法 X-RAY DIFFRACTION (1.403 Å) 主引用文献 A method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligand. J.Biomol.Nmr, 60, 2014
4Q21	MOLECULAR SWITCH FOR SIGNAL TRANSDUCTION: STRUCTURAL DIFFERENCES BETWEEN ACTIVE AND INACTIVE FORMS OF PROTOONCOGENIC RAS PROTEINS 分子名称: C-H-RAS P21 PROTEIN CATALYTIC DOMAIN, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Kim, S.-H. 登録日 1991-09-25 公開日 1992-07-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins. Science, 247, 1990
4QL3	Crystal Structure of a GDP-bound G12R Oncogenic Mutant of Human GTPase KRas 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Hunter, J.C, Manandhar, A, Gurbani, D, Chen, Z, Westover, K.D. 登録日 2014-06-10 公開日 2015-06-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.041 Å) 主引用文献 Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations. Mol Cancer Res., 13, 2015
3X1W	Ras-related protein Rap1B with GDP 分子名称: CADMIUM ION, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Noguchi, H, Ikegami, T, Akashi, S, Park, S.Y, Tame, J.R.H, Unzai, S. 登録日 2014-12-02 公開日 2015-06-03 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 The structure and conformational switching of Rap1B Biochem.Biophys.Res.Commun., 462, 2015
3X1Y	Ras-related protein Rap1B(L9V) with GppNHp 分子名称: CADMIUM ION, GLYCEROL, MAGNESIUM ION, ... 著者 Noguchi, H, Ikegami, T, Park, S.Y, Tame, J.R.H, Unzai, S. 登録日 2014-12-02 公開日 2015-06-03 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.168 Å) 主引用文献 The structure and conformational switching of Rap1B Biochem.Biophys.Res.Commun., 462, 2015
3X1X	Ras-related protein Rap1B with GppNHp 分子名称: CADMIUM ION, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Noguchi, H, Ikegami, T, Park, S.Y, Tame, J.R.H, Unzai, S. 登録日 2014-12-02 公開日 2015-06-03 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1 Å) 主引用文献 The structure and conformational switching of Rap1B Biochem.Biophys.Res.Commun., 462, 2015
3X1Z	Ras-related protein Rap1B(T65A) with GppNHp 分子名称: GLYCEROL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Noguchi, H, Ikegami, T, Park, S.Y, Tame, J.R.H, Unzai, S. 登録日 2014-12-02 公開日 2015-06-03 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 The structure and conformational switching of Rap1B Biochem.Biophys.Res.Commun., 462, 2015
421P	THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES 分子名称: H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER 著者 Krengel, U, John, J, Scherer, A, Kabsch, W, Wittinghofer, A, Pai, E.F. 登録日 1991-06-06 公開日 1994-01-31 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules. Cell(Cambridge,Mass.), 62, 1990
4RKF	Drosophila melanogaster Rab3 bound to GMPPNP 分子名称: MAGNESIUM ION, PENTAETHYLENE GLYCOL, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Lardong, J.A, Driller, J.H, Depner, H, Weise, C, Petzoldt, A, Wahl, M.C, Sigrist, S.J, Loll, B. 登録日 2014-10-13 公開日 2014-12-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structures of Drosophila melanogaster Rab2 and Rab3 bound to GMPPNP. Acta Crystallogr F Struct Biol Commun, 71, 2015
4RKE	Drosophila melanogaster Rab2 bound to GMPPNP 分子名称: GH01619p, MAGNESIUM ION, PENTAETHYLENE GLYCOL, ... 著者 Lardong, J.A, Driller, J.H, Depner, H, Weise, C, Petzoldt, A, Wahl, M.C, Sigrist, S.J, Loll, B. 登録日 2014-10-13 公開日 2014-12-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.0006 Å) 主引用文献 Structures of Drosophila melanogaster Rab2 and Rab3 bound to GMPPNP. Acta Crystallogr F Struct Biol Commun, 71, 2015
4TQ9	Crystal Structure of a GDP-bound G12V Oncogenic Mutant of Human GTPase KRas 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Hunter, J.C, Manandhar, A, Gurbani, D, Chen, Z, Westover, K.D. 登録日 2014-06-10 公開日 2015-06-10 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.491 Å) 主引用文献 Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations. Mol Cancer Res., 13, 2015
4AII	Crystal structure of the rat REM2 GTPase - G domain bound to GDP 分子名称: GTP-BINDING PROTEIN REM 2, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Reymond, P, Coquard, A, Chenon, M, Zeghouf, M, El Marjou, A, Thompson, A, Menetrey, J. 登録日 2012-02-10 公開日 2012-06-13 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.66 Å) 主引用文献 Structure of the Gdp-Bound G Domain of the Rgk Protein Rem2. Acta Crystallogr.,Sect.F, 68, 2012
4RSG	Neutron crystal structure of Ras bound to the GTP analogue GppNHp 分子名称: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER 著者 Knihtila, R.R, Holzapfel, G, Weiss, K.L, Meilleur, F, Mattos, C. 登録日 2014-11-07 公開日 2015-11-04 最終更新日 2024-02-28 実験手法 NEUTRON DIFFRACTION (1.907 Å) 主引用文献 Neutron Crystal Structure of RAS GTPase Puts in Question the Protonation State of the GTP gamma-Phosphate. J.Biol.Chem., 290, 2015
4TQA	Crystal Structure of a GDP-bound G13D Oncogenic Mutant of Human GTPase KRas 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Hunter, J.C, Manandhar, A, Gurbani, D, Chen, Z, Westover, K.D. 登録日 2014-06-10 公開日 2015-06-10 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.13 Å) 主引用文献 Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations. Mol Cancer Res., 13, 2015

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