8JHL

GDP-bound KRAS G12D in complex with YK-8S

Summary for 8JHL

Entry DOI	10.2210/pdb8jhl/pdb
Descriptor	GTPase KRas, N-terminally processed, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	hydrolase/inhibitor, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	20578.16
Authors	Zhang, Z.M.,Wang, R.L. (deposition date: 2023-05-23, release date: 2024-01-31)
Primary citation	Yu, Z.,He, X.,Wang, R.,Xu, X.,Zhang, Z.,Ding, K.,Zhang, Z.M.,Tan, Y.,Li, Z. Simultaneous Covalent Modification of K-Ras(G12D) and K-Ras(G12C) with Tunable Oxirane Electrophiles. J.Am.Chem.Soc., 145:20403-20411, 2023 Cited by PubMed: 37534597 DOI: 10.1021/jacs.3c05899 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.10004053415 Å)

Structure validation