4Q21

MOLECULAR SWITCH FOR SIGNAL TRANSDUCTION: STRUCTURAL DIFFERENCES BETWEEN ACTIVE AND INACTIVE FORMS OF PROTOONCOGENIC RAS PROTEINS

Summary for 4Q21

DescriptorC-H-RAS P21 PROTEIN CATALYTIC DOMAIN, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
Functional Keywordsoncogene protein
Biological sourceHomo sapiens (human)
Cellular locationCell membrane. Isoform 2: Nucleus P01112
Total number of polymer chains1
Total molecular weight21791.65
Authors
Kim, S.-H. (deposition date: 1991-09-25, release date: 1992-07-15, Last modification date: 2017-11-29)
Primary citation
Milburn, M.V.,Tong, L.,deVos, A.M.,Brunger, A.,Yamaizumi, Z.,Nishimura, S.,Kim, S.H.
Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins.
Science, 247:939-945, 1990
PubMed: 2406906 (PDB entries with the same primary citation)
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers36 1.2% 4.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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171588
PDB entries from 2020-11-25