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4Q21

MOLECULAR SWITCH FOR SIGNAL TRANSDUCTION: STRUCTURAL DIFFERENCES BETWEEN ACTIVE AND INACTIVE FORMS OF PROTOONCOGENIC RAS PROTEINS

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0000165biological_processMAPK cascade
A0000166molecular_functionnucleotide binding
A0001934biological_processpositive regulation of protein phosphorylation
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006357biological_processregulation of transcription by RNA polymerase II
A0006897biological_processendocytosis
A0006935biological_processchemotaxis
A0007165biological_processsignal transduction
A0007166biological_processcell surface receptor signaling pathway
A0007264biological_processsmall GTPase-mediated signal transduction
A0007265biological_processRas protein signal transduction
A0008284biological_processpositive regulation of cell population proliferation
A0008285biological_processnegative regulation of cell population proliferation
A0008286biological_processinsulin receptor signaling pathway
A0009887biological_processanimal organ morphogenesis
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0010863biological_processpositive regulation of phospholipase C activity
A0014044biological_processSchwann cell development
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0019003molecular_functionGDP binding
A0030335biological_processpositive regulation of cell migration
A0032729biological_processpositive regulation of type II interferon production
A0032956biological_processregulation of actin cytoskeleton organization
A0034260biological_processnegative regulation of GTPase activity
A0042088biological_processT-helper 1 type immune response
A0042127biological_processregulation of cell population proliferation
A0042552biological_processmyelination
A0042832biological_processdefense response to protozoan
A0043406biological_processpositive regulation of MAP kinase activity
A0043410biological_processpositive regulation of MAPK cascade
A0043495molecular_functionprotein-membrane adaptor activity
A0043524biological_processnegative regulation of neuron apoptotic process
A0043547biological_processpositive regulation of GTPase activity
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046330biological_processpositive regulation of JNK cascade
A0048144biological_processfibroblast proliferation
A0048146biological_processpositive regulation of fibroblast proliferation
A0048169biological_processregulation of long-term neuronal synaptic plasticity
A0048471cellular_componentperinuclear region of cytoplasm
A0050679biological_processpositive regulation of epithelial cell proliferation
A0050852biological_processT cell receptor signaling pathway
A0051402biological_processneuron apoptotic process
A0051726biological_processregulation of cell cycle
A0060612biological_processadipose tissue development
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0071480biological_processcellular response to gamma radiation
A0090303biological_processpositive regulation of wound healing
A0090314biological_processpositive regulation of protein targeting to membrane
A0090398biological_processcellular senescence
A0090402biological_processoncogene-induced cell senescence
A0097193biological_processintrinsic apoptotic signaling pathway
A0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
A0098978cellular_componentglutamatergic synapse
A1900029biological_processpositive regulation of ruffle assembly
A1905360cellular_componentGTPase complex
A2000630biological_processpositive regulation of miRNA metabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 273
ChainResidue
ASER17
AGDP274
AHOH401
AHOH403
AHOH404
AHOH405

site_idAC2
Number of Residues22
DetailsBINDING SITE FOR RESIDUE GDP A 274
ChainResidue
ALYS16
ASER17
AALA18
APHE28
AASP30
AASN116
ALYS117
AASP119
ALEU120
ASER145
AALA146
ALYS147
AMG273
AHOH401
AHOH402
AHOH403
AHOH405
AHOH414
AHOH443
AGLY12
AGLY13
AGLY15

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues5
DetailsBINDING: BINDING => ECO:0000269|PubMed:16698776
ChainResidueDetails
AGLY13
AVAL29
AALA59
AASN116
ASER145

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N-acetylmethionine; in GTPase HRas; alternate => ECO:0000269|Ref.12
ChainResidueDetails
AMET1

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: N-acetylthreonine; in GTPase HRas, N-terminally processed => ECO:0000269|Ref.12
ChainResidueDetails
ATHR2

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:9020151
ChainResidueDetails
ACYS118

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000269|PubMed:8626715
ChainResidueDetails
ACYS186

site_idSWS_FT_FI6
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:15705808, ECO:0000269|PubMed:16000296, ECO:0000269|PubMed:2661017, ECO:0000269|PubMed:8626715
ChainResidueDetails
ACYS181

site_idSWS_FT_FI7
Number of Residues1
DetailsLIPID: S-palmitoyl cysteine; alternate => ECO:0000269|PubMed:15705808, ECO:0000269|PubMed:16000296, ECO:0000269|PubMed:2661017, ECO:0000269|PubMed:8626715
ChainResidueDetails
ACYS184

site_idSWS_FT_FI8
Number of Residues1
DetailsLIPID: S-farnesyl cysteine => ECO:0000269|PubMed:8626715
ChainResidueDetails
ACYS186

site_idSWS_FT_FI9
Number of Residues1
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486, ECO:0000269|PubMed:8626575, ECO:0000269|PubMed:8626586, ECO:0000269|PubMed:9632667
ChainResidueDetails
ATHR35

site_idSWS_FT_FI10
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:30442762
ChainResidueDetails
ALYS170

218853

PDB entries from 2024-04-24

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