8JJS

Human K-Ras G12D (GDP-bound) in complex with cyclic peptide inhibitor AP10343

Summary for 8JJS

• Entry DOI: 10.2210/pdb8jjs/pdb
• Descriptor: Isoform 2B of GTPase KRas, MAA-ILE-SAR-SAR-7T2-SAR-IAE-LEU-MEA-MLE-7TK, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
• Functional Keywords: cyclic peptide, oncology, signaling protein-inhibitor complex, signaling protein/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 22330.37

Authors

Irie, M.,Fukami, T.A.,Tanada, M.,Ohta, A.,Torizawa, T. (deposition date: 2023-05-31, release date: 2023-07-26, Last modification date: 2023-11-15)

• Primary citation: Tanada, M.,Tamiya, M.,Matsuo, A.,Chiyoda, A.,Takano, K.,Ito, T.,Irie, M.,Kotake, T.,Takeyama, R.,Kawada, H.,Hayashi, R.,Ishikawa, S.,Nomura, K.,Furuichi, N.,Morita, Y.,Kage, M.,Hashimoto, S.,Nii, K.,Sase, H.,Ohara, K.,Ohta, A.,Kuramoto, S.,Nishimura, Y.,Iikura, H.,Shiraishi, T.; Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor.; J.Am.Chem.Soc., 145:16610-16620, 2023; PubMed: 37463267; DOI: 10.1021/jacs.3c03886

Experimental method

X-RAY DIFFRACTION (1.534 Å)