8JJS
Human K-Ras G12D (GDP-bound) in complex with cyclic peptide inhibitor AP10343
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoform 2B of GTPase KRas | polymer | 179 | 20150.6 | 1 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (human) | |
| 2 | B (I) | MAA-ILE-SAR-SAR-7T2-SAR-IAE-LEU-MEA-MLE-7TK | polymer | 11 | 1424.1 | 1 | synthetic construct | ||
| 3 | C (A) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 4 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | E, F, G (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 6 | H, I (A, I) | water | water | 18.0 | 122 | Chemie (HOH) |
Sequence modifications
A: 2 - 174 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
| Asp 12 | Gly 12 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21574.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 755.7 | |
| All* | Total formula weight | 22330.4 |
