8OSM

GTPASE HRAS IN COMPLEX WITH ZN-CYCLEN AT 200 MPA PRESSURE

Summary for 8OSM

• Entry DOI: 10.2210/pdb8osm/pdb
• Related: 8OSN 8OSO
• Descriptor: GTPase HRas, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: g protein, signaling protein, hpmx, oncoprotein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 19571.86

Authors

Colloc'h, N.,Girard, E.,Prange, T.,Kalbitzer, H.R. (deposition date: 2023-04-19, release date: 2024-05-08)

• Primary citation: Girard, E.,Lopes, P.,Spoerner, M.,Dhaussy, A.C.,Prange, T.,Kalbitzer, H.R.,Colloc'h, N.; High pressure promotes binding of the allosteric inhibitor Zn2+-cyclen in crystals of activated H-Ras.; Chemistry, :e202400304-e202400304, 2024; PubMed: 38647362; DOI: 10.1002/chem.202400304

Experimental method

X-RAY DIFFRACTION (2.05 Å)