8OSO
GTPase HRAS in complex with Zn-cyclen under 500 MPa pressure
Summary for 8OSO
| Entry DOI | 10.2210/pdb8oso/pdb |
| Related | 8OSM 8OSN |
| Descriptor | GTPase HRas, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, ... (7 entities in total) |
| Functional Keywords | g protein, signaling protein, hpmx, oncoprotein |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 19809.54 |
| Authors | Colloc'h, N.,Prange, T.,Girard, E.,Kalbitzer, H.R. (deposition date: 2023-04-19, release date: 2024-05-08) |
| Primary citation | Girard, E.,Lopes, P.,Spoerner, M.,Dhaussy, A.C.,Prange, T.,Kalbitzer, H.R.,Colloc'h, N. High pressure promotes binding of the allosteric inhibitor Zn2+-cyclen in crystals of activated H-Ras. Chemistry, :e202400304-e202400304, 2024 Cited by PubMed: 38647362DOI: 10.1002/chem.202400304 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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