PDB: 437 件ウェブページステータス検索Chemie searchBIRD

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6S4J	Crystal structure of zinc free A14E, B25H, B29K(N(eps)-[2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl]), desB27, desB30 human insulin 分子名称: IMIDAZOLE, Insulin, KUT [2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl] 著者 Johansson, E. 登録日 2019-06-28 公開日 2020-07-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Molecular engineering of safe and efficacious oral basal insulin. Nat Commun, 11, 2020
6S4I	Crystal structure of zinc free A14E, B25H, B29K(N(eps)-[2-(2-[2-(2-[2-(Octadecandioyl-gamma-Glu)amino]ethoxy)ethoxy]acetylamino)ethoxy]ethoxy)acetyl]), desB30 human insulin 分子名称: Insulin, NITRATE ION 著者 Johansson, E. 登録日 2019-06-28 公開日 2020-07-15 最終更新日 2020-08-12 実験手法 X-RAY DIFFRACTION (1.511 Å) 主引用文献 Molecular engineering of safe and efficacious oral basal insulin. Nat Commun, 11, 2020
6VEP	Human insulin in complex with the human insulin microreceptor in turn in complex with Fv 83-7 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Lawrence, M.C, Menting, J.G.T. 登録日 2020-01-02 公開日 2020-06-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 A structurally minimized yet fully active insulin based on cone-snail venom insulin principles. Nat.Struct.Mol.Biol., 27, 2020
6VWI	Head region of the closed conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II. 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor II, Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain 著者 Xu, Y, Kirk, N.S, Lawrence, M.C, Croll, T.I. 登録日 2020-02-19 公開日 2020-05-13 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor. Structure, 28, 2020
6VWG	Head region of the open conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II. 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor II, Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain 著者 Xu, Y, Kirk, N.S, Lawrence, M.C, Croll, T.I. 登録日 2020-02-19 公開日 2020-05-13 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (3.21 Å) 主引用文献 How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor. Structure, 28, 2020
6K59	Structure of Glargine insulin in 20% acetic acid-d4 (pH 1.9) 分子名称: Glargine Insulin Chain-A, Glargine insulin Chain-B 著者 Ratha, B.N, Kar, R.K, Bhunia, A. 登録日 2019-05-28 公開日 2020-05-06 実験手法 SOLUTION NMR 主引用文献 Molecular Details of a Salt Bridge and Its Role in Insulin Fibrillation by NMR and Raman Spectroscopic Analysis. J.Phys.Chem.B, 124, 2020
6JR3	Crystal structure of insulin hexamer fitted into cryo EM density map where each dimer was kept as rigid body 分子名称: Insulin A chain, Insulin B chain 著者 Sengupta, J, Pathak, B.K, Bhakta, S. 登録日 2019-04-02 公開日 2020-04-22 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (14.5 Å) 主引用文献 Resveratrol as a nontoxic excipient stabilizes insulin in a bioactive hexameric form. J.Comput.Aided Mol.Des., 34, 2020
6JK8	Cryo-EM structure of the full-length human IGF-1R in complex with insulin 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, ... 著者 Zhang, X, Yu, D, Wang, T. 登録日 2019-02-27 公開日 2020-03-04 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (4.7 Å) 主引用文献 Visualization of Ligand-Bound Ectodomain Assembly in the Full-Length Human IGF-1 Receptor by Cryo-EM Single-Particle Analysis. Structure, 28, 2020
6UM2	Structure of M-6-P/IGFII Receptor and IGFII complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cation-independent mannose-6-phosphate receptor, Insulin-like growth factor II 著者 Wang, R, Qi, X, Li, X. 登録日 2019-10-08 公開日 2020-02-26 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (4.32 Å) 主引用文献 Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments Sci Adv, 6, 2020
6O17	Recombinant Human Insulin 分子名称: Insulin chain A, Insulin chain B 著者 Reyes-Grajeda, J.P. 登録日 2019-02-18 公開日 2020-02-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Human WT insulin To Be Published
6NWV	Insulin Lispro Analog 分子名称: CHLORIDE ION, GLYCEROL, Insulin A chain, ... 著者 Cruz-Rangel, A, Romero, A, Reyes-Grajeda, J.P. 登録日 2019-02-07 公開日 2020-02-12 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.601 Å) 主引用文献 Crystal structure of Lispro hexameric insulin analog To Be Published
6Q8Q	Bovine Insulin under 2 kbar of argon 分子名称: ARGON, Insulin 著者 Prange, T, Carpentier, P. 登録日 2018-12-16 公開日 2020-01-15 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Argon-labelling protein crystals by high pressure cooling at 2 kbar To be published
6OR0	Crystal structure of Insulin from Non-merohedrally twinned crystals 分子名称: Insulin chain A, Insulin chain B 著者 Sevvana, M, Ruf, M, Uson, I, Sheldrick, G.M, Herbst-Irmer, R. 登録日 2019-04-29 公開日 2019-12-11 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Non-merohedral twinning: from minerals to proteins. Acta Crystallogr D Struct Biol, 75, 2019
6SOF	human insulin receptor ectodomain bound by 4 insulin 分子名称: Insulin, Insulin receptor 著者 Gutmann, T, Schaefer, I.B, Poojari, C.S, Vattulainen, I, Strauss, M, Coskun, U. 登録日 2019-08-29 公開日 2019-11-13 最終更新日 2020-05-27 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain. J.Cell Biol., 219, 2020
6TYH	Four-Disulfide Insulin Analog A22/B22 分子名称: ACETONE, CHLORIDE ION, GLYCEROL, ... 著者 Blakely, A.D, Xiong, X. 登録日 2019-08-08 公開日 2019-11-13 最終更新日 2020-03-11 実験手法 X-RAY DIFFRACTION (1.600019 Å) 主引用文献 Novel four-disulfide insulin analog with high aggregation stability and potency. Chem Sci, 11, 2020
6PYH	Cryo-EM structure of full-length IGF1R-IGF1 complex. Only the extracellular region of the complex is resolved. 分子名称: Insulin-like growth factor 1 receptor, Insulin-like growth factor I 著者 Li, J, Choi, E, Yu, H.T, Bai, X.C. 登録日 2019-07-29 公開日 2019-10-23 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Structural basis of the activation of type 1 insulin-like growth factor receptor. Nat Commun, 10, 2019
6RVA	STRUCTURE OF [ASP58]-IGF-I ANALOGUE 分子名称: Insulin-like growth factor I 著者 Jiracek, J, Zakova, L, Socha, O. 登録日 2019-05-31 公開日 2019-10-02 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses. J.Biol.Chem., 294, 2019
6PXV	Cryo-EM structure of full-length insulin receptor bound to 4 insulin. 3D refinement was focused on the extracellular region. 分子名称: Insulin, Insulin receptor 著者 Uchikawa, E, Choi, E, Shang, G.J, Yu, H.T, Bai, X.C. 登録日 2019-07-27 公開日 2019-09-04 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex. Elife, 8, 2019
6PXW	Cryo-EM structure of full-length insulin receptor bound to 4 insulin. 3D refinement was focused on the top part of the receptor complex. 分子名称: Insulin, Insulin receptor 著者 Uchikawa, E, Choi, E, Shang, G.J, Yu, H.T, Bai, X.C. 登録日 2019-07-28 公開日 2019-09-04 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex. Elife, 8, 2019
6H3M	The crystal structure of a human seleno-insulin analog 分子名称: Insulin 著者 Lansky, S, Weil-Ktorza, O, Metanis, N, Shoham, G. 登録日 2018-07-19 公開日 2019-08-14 最終更新日 2020-08-26 実験手法 X-RAY DIFFRACTION (1.821 Å) 主引用文献 Substitution of an Internal Disulfide Bridge with a Diselenide Enhances both Foldability and Stability of Human Insulin. Chemistry, 25, 2019
6S34	Zinc free, dimeric human insulin determined to 1.35 Angstrom resolution 分子名称: 1,2-ETHANEDIOL, Insulin A chain, Insulin B chain 著者 Johansson, E. 登録日 2019-06-24 公開日 2019-07-03 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Zinc free, dimeric human insulin determined to 1.35 Angstrom resolution Not Published
6GV0	Insulin glulisine 分子名称: FORMIC ACID, Insulin, ZINC ION 著者 Chayen, N.E, Helliwell, J.R, Solomon-Gamsu, H.V, Govada, L, Morgan, M, Gillis, R.B, Adams, G. 登録日 2018-06-20 公開日 2019-07-03 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.26 Å) 主引用文献 Analysis of insulin glulisine at the molecular level by X-ray crystallography and biophysical techniques. Sci Rep, 11, 2021
6P4Z	Structure of gadolinium-caged cobalt (III) insulin hexamer 分子名称: CHLORIDE ION, COBALT (II) ION, GADOLINIUM ATOM, ... 著者 Tran, T.H, Taylor, S.K, Stojanovic, M.N, Tong, L. 登録日 2019-05-29 公開日 2019-06-12 最終更新日 2019-12-18 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Insulin Hexamer-Caged Gadolinium Ion as MRI Contrast-o-phore ChemBioChem, 24, 2018
6GNQ	Monoclinic crystalline form of human insulin, complexed with meta-cresol 分子名称: 1,2-ETHANEDIOL, Insulin, M-CRESOL, ... 著者 Margiolaki, I, Karavassili, F, Valmas, A, Dimarogona, M, Giannopoulou, A.E, Fili, S, Schluckebier, G, Norrman, M, Beckers, D, Fitch, A.N. 登録日 2018-05-31 公開日 2019-06-12 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Monoclinic crystalline form of human insulin, complexed with meta-cresol To Be Published
6QRK	High pressure structure of bovine insulin (200 MPa) 分子名称: Insulin 著者 Kurpiewska, K, Milaczewska, A, Lewinski, K. 登録日 2019-02-19 公開日 2019-03-06 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.102 Å) 主引用文献 Insulin conformational changes under high pressure in structural studies and molecular dynamics simulations J.Mol.Struct., 2020

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