8FPS
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![BU of 8fps by Molmil](/molmil-images/mine/8fps) | GluA2 flip Q isoform N619K mutant of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg/N619K) | 分子名称: | CHLORIDE ION, Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit | 著者 | Nakagawa, T. | 登録日 | 2023-01-05 | 公開日 | 2024-02-28 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.38 Å) | 主引用文献 | The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport. Nat.Struct.Mol.Biol., 31, 2024
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8FQ1
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8GMH
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![BU of 8gmh by Molmil](/molmil-images/mine/8gmh) | Crystal Structure of the ternary complex of TelA-LXG, LapA3, and LapA4 | 分子名称: | 1,2-ETHANEDIOL, LXG domain-containing protein, LapA3, ... | 著者 | Klein, T.A, Shah, P.Y, Gkragkopoulou, P, Grebenc, D.W, Kim, Y, Whitney, J.C. | 登録日 | 2023-03-25 | 公開日 | 2024-01-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of a tripartite protein complex that targets toxins to the type VII secretion system. Proc.Natl.Acad.Sci.USA, 121, 2024
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8G10
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8G1J
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6FID
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6FJ0
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6FJ6
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8H0B
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5NW8
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![BU of 5nw8 by Molmil](/molmil-images/mine/5nw8) | Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp032 and Fasudil | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE, UPF0418 protein FAM164A, ... | 著者 | Mueller, J.M, Heine, A, Klebe, G. | 登録日 | 2017-05-05 | 公開日 | 2018-05-30 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.086 Å) | 主引用文献 | Conceptional Design of Self-Assembling Bisubstrate-like Inhibitors of Protein Kinase A Resulting in a Boronic Acid Glutamate Linkage Acs Omega, 2019
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8H0A
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6FK9
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![BU of 6fk9 by Molmil](/molmil-images/mine/6fk9) | Crystal structure of N2C/D282C stabilized opsin bound to RS09 | 分子名称: | (2~{S})-3-methyl-2-phenyl-1-spiro[1,3-benzodioxole-2,4'-piperidine]-1'-yl-butan-1-one, PALMITIC ACID, Rhodopsin, ... | 著者 | Mattle, D, Standfuss, J, Dawson, R. | 登録日 | 2018-01-23 | 公開日 | 2018-04-04 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | 主引用文献 | Ligand channel in pharmacologically stabilized rhodopsin. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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8H09
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8H0C
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6FJ8
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8GUB
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![BU of 8gub by Molmil](/molmil-images/mine/8gub) | Cryo-EM structure of cancer-specific PI3Kalpha mutant H1047R in complex with BYL-719 | 分子名称: | (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 著者 | Liu, X, Zhou, Q, Hart, J.R, Xu, Y, Yang, S, Yang, D, Vogt, P.K, Wang, M.-W. | 登録日 | 2022-09-11 | 公開日 | 2022-11-23 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.73 Å) | 主引用文献 | Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3K alpha. Proc.Natl.Acad.Sci.USA, 119, 2022
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8GVJ
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![BU of 8gvj by Molmil](/molmil-images/mine/8gvj) | Crystal structure of cMET kinase domain bound by D6808 | 分子名称: | (1^4Z,5^2E)-6^3-(trifluoromethyl)-5^1,5^6-dihydro-1^1H-8-aza-2(3,6)-quinolina-5(1,3)-pyridazina-1(4,1)-pyrazola-6(1,4)-benzenacyclododecaphane-5^6,7-dione, Hepatocyte growth factor receptor | 著者 | Chen, Y.H, Qu, L.Z. | 登録日 | 2022-09-15 | 公開日 | 2022-11-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | 主引用文献 | Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment. J.Med.Chem., 65, 2022
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8H0D
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![BU of 8h0d by Molmil](/molmil-images/mine/8h0d) | Structure of the thermolabile hemolysin from Vibrio alginolyticus (in complex with docosahexaenoic acid) | 分子名称: | 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, MAGNESIUM ION, ... | 著者 | Ma, Q, Wang, C. | 登録日 | 2022-09-28 | 公開日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Catalytic site flexibility facilitates the substrate and catalytic promiscuity of Vibrio dual lipase/transferase. Nat Commun, 14, 2023
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6FI3
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![BU of 6fi3 by Molmil](/molmil-images/mine/6fi3) | Crystal structure of ERK2 in complex with an adenosine derivative | 分子名称: | (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-(azanyloxymethyl)oxolane-3,4-diol, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... | 著者 | Gelin, M, Labesse, G. | 登録日 | 2018-01-16 | 公開日 | 2019-01-30 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | Crystal structure of ERK2 in complex with an adenosine derivative To be published
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6FJZ
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6FKB
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![BU of 6fkb by Molmil](/molmil-images/mine/6fkb) | Crystal structure of N2C/D282C stabilized opsin bound to RS13 | 分子名称: | 2-(4-chlorophenyl)-1-spiro[1,3-benzodioxole-2,4'-piperidine]-1'-yl-ethanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, PALMITIC ACID, ... | 著者 | Mattle, D, Standfuss, J, Dawson, R. | 登録日 | 2018-01-23 | 公開日 | 2018-04-04 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.03 Å) | 主引用文献 | Ligand channel in pharmacologically stabilized rhodopsin. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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8GNJ
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8GNI
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8GQ5
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8GPN
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![BU of 8gpn by Molmil](/molmil-images/mine/8gpn) | Human menin in complex with H3K79Me2 nucleosome | 分子名称: | DNA (177-MER), Histone H2A type 1, Histone H2B 1.1, ... | 著者 | Lin, J, Yu, D, Lam, W.H, Dang, S, Zhai, Y, Li, X.D. | 登録日 | 2022-08-26 | 公開日 | 2023-02-15 | 最終更新日 | 2023-03-01 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Menin "reads" H3K79me2 mark in a nucleosomal context. Science, 379, 2023
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