PDB: 2862 件ウェブページステータス検索Chemie searchBIRD

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6BN7	Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET23 PROTAC. 分子名称: Bromodomain-containing protein 4, DNA damage-binding protein 1, Protein cereblon, ... 著者 Nowak, R.P, DeAngelo, S.L, Buckley, D, Bradner, J.E, Fischer, E.S. 登録日 2017-11-16 公開日 2018-05-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.501 Å) 主引用文献 Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat. Chem. Biol., 14, 2018
6BOY	Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET6 PROTAC. 分子名称: 2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-(8-{[({2-[(3S)-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}oxy)acetyl]amino}octyl)acetamide, Bromodomain-containing protein 4, DNA damage-binding protein 1, ... 著者 Nowak, R.P, DeAngelo, S.L, Buckley, D, Bradner, J.E, Fischer, E.S. 登録日 2017-11-21 公開日 2018-05-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.33 Å) 主引用文献 Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat. Chem. Biol., 14, 2018
6BNB	Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET57 PROTAC 分子名称: Bromodomain-containing protein 4, DNA damage-binding protein 1, Protein cereblon, ... 著者 Nowak, R.P, DeAngelo, S.L, Buckley, D, Ishoey, M, He, Z, Zhang, T, Bradner, J.E, Fischer, E.S. 登録日 2017-11-16 公開日 2018-05-30 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (6.343 Å) 主引用文献 Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat. Chem. Biol., 14, 2018
6WCQ	Structure of a substrate-bound DQC ubiquitin ligase 分子名称: Cullin-1, F-box/LRR-repeat protein 17, Kelch-like ECH-associated protein 1, ... 著者 Mena, E.L, Jevtic, P, Greber, B.J, Gee, C.L, Lew, B.G, Akopian, D, Nogales, E, Kuriyan, J, Rape, M. 登録日 2020-03-31 公開日 2020-08-19 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (8.5 Å) 主引用文献 Structural basis for dimerization quality control. Nature, 586, 2020
6BN8	Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET55 PROTAC. 分子名称: Bromodomain-containing protein 4, DNA damage-binding protein 1,DNA damage-binding protein 1, Protein cereblon, ... 著者 Nowak, R.P, DeAngelo, S.L, Buckley, D, Bradner, J.E, Fischer, E.S. 登録日 2017-11-16 公開日 2018-06-06 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.990035 Å) 主引用文献 Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat. Chem. Biol., 14, 2018
5IG9	Crystal structure of macrocyclase MdnC bound with precursor peptide MdnA from Microcystis aeruginosa MRC 分子名称: ATP grasp ligase, Microviridin 著者 Li, K, Condurso, H.L, Bruner, S.D. 登録日 2016-02-27 公開日 2016-09-21 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.665 Å) 主引用文献 Structural basis for precursor protein-directed ribosomal peptide macrocyclization. Nat.Chem.Biol., 12, 2016
5T5S	A fragment of a human tRNA synthetase 分子名称: Alanine--tRNA ligase, cytoplasmic 著者 Sun, L, Schimmel, P. 登録日 2016-08-31 公開日 2016-11-30 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.202 Å) 主引用文献 Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
8AJN	Structure of the human DDB1-DCAF12 complex 分子名称: DDB1- and CUL4-associated factor 12, DNA damage-binding protein 1 著者 Pla-Prats, C, Cavadini, S, Kempf, G, Thoma, N.H. 登録日 2022-07-28 公開日 2022-11-09 最終更新日 2023-05-24 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Recognition of the CCT5 di-Glu degron by CRL4 DCAF12 is dependent on TRiC assembly. Embo J., 42, 2023
8AJM	Structure of human DDB1-DCAF12 in complex with the C-terminus of CCT5 分子名称: DDB1- and CUL4-associated factor 12, DNA damage-binding protein 1, T-complex protein 1 subunit epsilon 著者 Pla-Prats, C, Cavadini, S, Kempf, G, Thoma, N.H. 登録日 2022-07-28 公開日 2022-11-09 最終更新日 2023-05-24 実験手法 ELECTRON MICROSCOPY (2.83 Å) 主引用文献 Recognition of the CCT5 di-Glu degron by CRL4 DCAF12 is dependent on TRiC assembly. Embo J., 42, 2023
8AJO	Negative-stain electron microscopy structure of DDB1-DCAF12-CCT5 分子名称: DDB1- and CUL4-associated factor 12, DNA damage-binding protein 1, T-complex protein 1 subunit epsilon 著者 Pla-Prats, C, Cavadini, S, Kempf, G, Thoma, N.H. 登録日 2022-07-28 公開日 2022-11-09 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (30.6 Å) 主引用文献 Recognition of the CCT5 di-Glu degron by CRL4 DCAF12 is dependent on TRiC assembly. Embo J., 42, 2023
8OW1	Cryo-EM structure of the yeast Inner kinetochore bound to a CENP-A nucleosome. 分子名称: C0N3, Centromere DNA-binding protein complex CBF3 subunit B, Centromere DNA-binding protein complex CBF3 subunit C, ... 著者 Dendooven, T.D, Zhang, Z, Yang, J, McLaughlin, S, Schwabb, J, Scheres, S, Yatskevich, S, Barford, D. 登録日 2023-04-26 公開日 2023-08-09 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere. Sci Adv, 9, 2023
7MEY	Structure of yeast Ubr1 in complex with Ubc2 and monoubiquitinated N-degron 分子名称: 2-(ethylamino)ethane-1-thiol, E3 ubiquitin-protein ligase UBR1, Monoubiquitinated N-degron, ... 著者 Pan, M, Zheng, Q, Wang, T, Liang, L, Yu, Y, Liu, L, Zhao, M. 登録日 2021-04-08 公開日 2021-11-24 最終更新日 2021-12-22 実験手法 ELECTRON MICROSCOPY (3.67 Å) 主引用文献 Structural insights into Ubr1-mediated N-degron polyubiquitination. Nature, 600, 2021
8XGC	Structure of yeast replisome associated with FACT and histone hexamer, Composite map 分子名称: ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45, Chromosome segregation in meiosis protein 3, ... 著者 Li, N, Gao, Y, Yu, D, Gao, N, Zhai, Y. 登録日 2023-12-15 公開日 2024-02-14 最終更新日 2024-04-10 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Parental histone transfer caught at the replication fork. Nature, 627, 2024
3ASK	Structure of UHRF1 in complex with histone tail 分子名称: E3 ubiquitin-protein ligase UHRF1, Histone H3.3, ZINC ION 著者 Arita, K, Sugita, K, Unoki, M, Hamamoto, R, Sekiyama, N, Tochio, H, Ariyoshi, M, Shirakawa, M. 登録日 2010-12-16 公開日 2012-01-25 最終更新日 2013-06-05 実験手法 X-RAY DIFFRACTION (2.904 Å) 主引用文献 Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1 Proc.Natl.Acad.Sci.USA, 109, 2012
8D80	Cereblon~DDB1 bound to Iberdomide and Ikaros ZF1-2-3 分子名称: (3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, DNA damage-binding protein 1, DNA-binding protein Ikaros, ... 著者 Watson, E.R, Lander, G.C. 登録日 2022-06-07 公開日 2022-07-20 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Molecular glue CELMoD compounds are regulators of cereblon conformation. Science, 378, 2022
7K79	CBF3 分子名称: Centromere DNA-binding protein complex CBF3 subunit B, Centromere DNA-binding protein complex CBF3 subunit C, Suppressor of kinetochore protein 1 著者 Ruifang, G, Yawen, B. 登録日 2020-09-22 公開日 2021-03-31 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structural and dynamic mechanisms of CBF3-guided centromeric nucleosome formation. Nat Commun, 12, 2021
4ORH	Crystal structure of RNF8 bound to the UBC13/MMS2 heterodimer 分子名称: E3 ubiquitin-protein ligase RNF8, Ubiquitin-conjugating enzyme E2 N, Ubiquitin-conjugating enzyme E2 variant 2, ... 著者 Campbell, S.J, Edwards, R.A, Glover, J.N.M. 登録日 2014-02-11 公開日 2014-02-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (4.802 Å) 主引用文献 Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation. J.Biol.Chem., 287, 2012
4P5O	Structure of an RBX1-UBC12~NEDD8-CUL1-DCN1 complex: a RING-E3-E2~ubiquitin-like protein-substrate intermediate trapped in action 分子名称: Cullin-1, DCN1-like protein 1, E3 ubiquitin-protein ligase RBX1, ... 著者 Scott, D.C, Schulman, B.A. 登録日 2014-03-18 公開日 2014-07-02 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.1071 Å) 主引用文献 Structure of a RING E3 Trapped in Action Reveals Ligation Mechanism for the Ubiquitin-like Protein NEDD8. Cell, 157, 2014
5AIT	A complex of of RNF4-RING domain, UbeV2, Ubc13-Ub (isopeptide crosslink) 分子名称: E3 UBIQUITIN-PROTEIN LIGASE RNF4, POLYUBIQUITIN-C, UBIQUITIN-CONJUGATING ENZYME E2 N, ... 著者 Branigan, E, Naismith, J.H. 登録日 2015-02-17 公開日 2015-07-08 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Structural Basis for the Ring Catalyzed Synthesis of K63 Linked Ubiquitin Chains Nat.Struct.Mol.Biol., 22, 2015
6GYU	Cryo-EM structure of the CBF3-msk complex of the budding yeast kinetochore 分子名称: Centromere DNA-binding protein complex CBF3 subunit A, Centromere DNA-binding protein complex CBF3 subunit B, Centromere DNA-binding protein complex CBF3 subunit C, ... 著者 Yan, K, Zhang, Z, Yang, J, McLaughlin, S.H, Barford, D. 登録日 2018-07-02 公開日 2018-12-05 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Architecture of the CBF3-centromere complex of the budding yeast kinetochore. Nat. Struct. Mol. Biol., 25, 2018
6GYS	Cryo-EM structure of the CBF3-CEN3 complex of the budding yeast kinetochore 分子名称: Centromere DNA-binding protein complex CBF3 subunit A, Centromere DNA-binding protein complex CBF3 subunit B, Centromere DNA-binding protein complex CBF3 subunit C, ... 著者 Yan, K, Zhang, Z, Yang, J, McLaughlin, S.H, Barford, D. 登録日 2018-07-01 公開日 2018-12-05 最終更新日 2019-12-11 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 Architecture of the CBF3-centromere complex of the budding yeast kinetochore. Nat. Struct. Mol. Biol., 25, 2018
6GYP	Cryo-EM structure of the CBF3-core-Ndc10-DBD complex of the budding yeast kinetochore 分子名称: ARGININE, ASPARAGINE, Centromere DNA-binding protein complex CBF3 subunit A, ... 著者 Yan, K, Zhang, Z, Yang, J, McLaughlin, S.H, Barford, D. 登録日 2018-07-01 公開日 2018-12-05 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Architecture of the CBF3-centromere complex of the budding yeast kinetochore. Nat. Struct. Mol. Biol., 25, 2018
7ZN7	Cryo-EM structure of RCMV-E E27 bound to human DDB1 (deltaBPB) and rat STAT2 CCD 分子名称: B27a, DNA damage-binding protein 1, Signal transducer and activator of transcription, ... 著者 Lauer, S, Spahn, C.M.T, Schwefel, D. 登録日 2022-04-20 公開日 2022-11-09 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (3.78 Å) 主引用文献 Structural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor. Embo J., 42, 2023
7ZNN	Cryo-EM structure of RCMV-E E27 bound to human DDB1 (deltaBPB) and full-length rat STAT2 分子名称: B27a, DNA damage-binding protein 1, Signal transducer and activator of transcription, ... 著者 Lauer, S, Spahn, C.M.T, Schwefel, D. 登録日 2022-04-21 公開日 2022-11-09 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (4.8 Å) 主引用文献 Structural mechanism of CRL4-instructed STAT2 degradation via a novel cytomegaloviral DCAF receptor. Embo J., 42, 2023
6F07	CBF3 Core Complex 分子名称: Centromere DNA-binding protein complex CBF3 subunit B, Suppressor of kinetochore protein 1, ZINC ION 著者 Leber, V, Singleton, M.R. 登録日 2017-11-17 公開日 2017-12-13 最終更新日 2019-12-11 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural basis for assembly of the CBF3 kinetochore complex. EMBO J., 37, 2018

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