8D80

Cereblon~DDB1 bound to Iberdomide and Ikaros ZF1-2-3

Summary for 8D80

• Entry DOI: 10.2210/pdb8d80/pdb
• EMDB information: 27234 27235 27236 27237 27238 27239 27240 27241 27242
• Descriptor: DNA damage-binding protein 1, Protein cereblon, DNA-binding protein Ikaros, ... (5 entities in total)
• Functional Keywords: ubiquitin, crl4, adaptor, cereblon, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 188012.89

Authors

Watson, E.R.,Lander, G.C. (deposition date: 2022-06-07, release date: 2022-07-20, Last modification date: 2023-03-01)

• Primary citation: Watson, E.R.,Novick, S.,Matyskiela, M.E.,Chamberlain, P.P.,H de la Pena, A.,Zhu, J.,Tran, E.,Griffin, P.R.,Wertz, I.E.,Lander, G.C.; Molecular glue CELMoD compounds are regulators of cereblon conformation.; Science, 378:549-553, 2022; PubMed: 36378961; DOI: 10.1126/science.add7574

Experimental method

ELECTRON MICROSCOPY (3.6 Å)