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8D80

Cereblon~DDB1 bound to Iberdomide and Ikaros ZF1-2-3

Functional Information from GO Data
ChainGOidnamespacecontents
A0000781cellular_componentchromosome, telomeric region
A0003676molecular_functionnucleic acid binding
A0003677molecular_functionDNA binding
A0003684molecular_functiondamaged DNA binding
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0006281biological_processDNA repair
A0006289biological_processnucleotide-excision repair
A0006511biological_processubiquitin-dependent protein catabolic process
A0006915biological_processapoptotic process
A0006974biological_processDNA damage response
A0007056biological_processspindle assembly involved in female meiosis
A0010498biological_processproteasomal protein catabolic process
A0016055biological_processWnt signaling pathway
A0016567biological_processprotein ubiquitination
A0019076biological_processviral release from host cell
A0030674molecular_functionprotein-macromolecule adaptor activity
A0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
A0031465cellular_componentCul4B-RING E3 ubiquitin ligase complex
A0032991cellular_componentprotein-containing complex
A0034644biological_processcellular response to UV
A0035234biological_processectopic germ cell programmed cell death
A0035861cellular_componentsite of double-strand break
A0042752biological_processregulation of circadian rhythm
A0043066biological_processnegative regulation of apoptotic process
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0044725biological_processepigenetic programming in the zygotic pronuclei
A0044877molecular_functionprotein-containing complex binding
A0045070biological_processpositive regulation of viral genome replication
A0045722biological_processpositive regulation of gluconeogenesis
A0045732biological_processpositive regulation of protein catabolic process
A0046726biological_processpositive regulation by virus of viral protein levels in host cell
A0048511biological_processrhythmic process
A0051093biological_processnegative regulation of developmental process
A0051702biological_processbiological process involved in interaction with symbiont
A0070062cellular_componentextracellular exosome
A0070914biological_processUV-damage excision repair
A0071987molecular_functionWD40-repeat domain binding
A0080008cellular_componentCul4-RING E3 ubiquitin ligase complex
A0097602molecular_functioncullin family protein binding
A0160072molecular_functionubiquitin ligase complex scaffold activity
A1901990biological_processregulation of mitotic cell cycle phase transition
A2000242biological_processnegative regulation of reproductive process
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0016020cellular_componentmembrane
B0016567biological_processprotein ubiquitination
B0030177biological_processpositive regulation of Wnt signaling pathway
B0031333biological_processnegative regulation of protein-containing complex assembly
B0031334biological_processpositive regulation of protein-containing complex assembly
B0031464cellular_componentCul4A-RING E3 ubiquitin ligase complex
B0034766biological_processnegative regulation of monoatomic ion transmembrane transport
B0035641biological_processlocomotory exploration behavior
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0044325molecular_functiontransmembrane transporter binding
B0046872molecular_functionmetal ion binding
B0048471cellular_componentperinuclear region of cytoplasm
Functional Information from PROSITE/UniProt
site_idPS00028
Number of Residues21
DetailsZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cdi..CgiiCigpnvlmvHkrs..H
ChainResidueDetails
CCYS119-HIS139
CCYS147-HIS167
CCYS175-HIS195

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues22
DetailsZN_FING: C2H2-type 1 => ECO:0000255|PROSITE-ProRule:PRU00042
ChainResidueDetails
CLEU117-HIS139
BCYS326
BHIS378
BTRP380
BTRP386
BCYS391
BCYS394

site_idSWS_FT_FI2
Number of Residues22
DetailsZN_FING: C2H2-type 2 => ECO:0000255|PROSITE-ProRule:PRU00042
ChainResidueDetails
CPHE145-HIS167

site_idSWS_FT_FI3
Number of Residues22
DetailsZN_FING: C2H2-type 3 => ECO:0000255|PROSITE-ProRule:PRU00042
ChainResidueDetails
CPHE173-HIS195

site_idSWS_FT_FI4
Number of Residues2
DetailsSITE: Required for both pericentromeric heterochromatin localization and complete DNA binding => ECO:0000250
ChainResidueDetails
CASN159
CARG162

site_idSWS_FT_FI5
Number of Residues1
DetailsSITE: Required for both pericentromeric heterochromatin localization and DNA binding => ECO:0000250
ChainResidueDetails
CLEU188

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q03267
ChainResidueDetails
CTHR140

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q03267
ChainResidueDetails
CSER168
CSER196

219869

PDB entries from 2024-05-15

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