8D80
Cereblon~DDB1 bound to Iberdomide and Ikaros ZF1-2-3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | DNA damage-binding protein 1 | polymer | 1140 | 127097.5 | 1 | UniProt (Q16531) Pfam (PF10433) Pfam (PF03178) In PDB | Homo sapiens (human) | DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe |
| 2 | B | Protein cereblon | polymer | 442 | 50603.7 | 1 | UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226) In PDB | Homo sapiens (human) | |
| 3 | C | DNA-binding protein Ikaros | polymer | 87 | 9731.4 | 1 | UniProt (Q13422) Pfam (PF00096) In PDB | Homo sapiens (human) | Ikaros family zinc finger protein 1,Lymphoid transcription factor LyF-1 |
| 4 | B, C | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | B | (3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione | non-polymer | 449.5 | 1 | Chemie (8W7) |
Sequence modifications
C: 112 - 196 (UniProt: Q13422)
| PDB | External Database | Details |
|---|---|---|
| Gly 110 | - | expression tag |
| Ser 111 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 187432.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 580.3 | |
| All* | Total formula weight | 188012.9 |
