6BN8

Crystal structure of DDB1-CRBN-BRD4(BD1) complex bound to dBET55 PROTAC.

Summary for 6BN8

Entry DOI	10.2210/pdb6bn8/pdb
Descriptor	DNA damage-binding protein 1,DNA damage-binding protein 1, Protein cereblon, Bromodomain-containing protein 4, ... (4 entities in total)
Functional Keywords	protac, degrader, e3 ligase, crbn, ligase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	164551.57
Authors	Nowak, R.P.,DeAngelo, S.L.,Buckley, D.,Bradner, J.E.,Fischer, E.S. (deposition date: 2017-11-16, release date: 2018-06-06, Last modification date: 2023-10-04)
Primary citation	Nowak, R.P.,DeAngelo, S.L.,Buckley, D.,He, Z.,Donovan, K.A.,An, J.,Safaee, N.,Jedrychowski, M.P.,Ponthier, C.M.,Ishoey, M.,Zhang, T.,Mancias, J.D.,Gray, N.S.,Bradner, J.E.,Fischer, E.S. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat. Chem. Biol., 14:706-714, 2018 Cited by PubMed: 29892083 DOI: 10.1038/s41589-018-0055-y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.99003499985 Å)

Structure validation