8EFO
 
 | | PZM21-bound mu-opioid receptor-Gi complex | | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhuang, Y, Wang, Y, Guo, S, Zhou, X.E, Rao, Q, He, X, He, B, Liu, J, Zhou, Q, Wang, X, Liu, W, Jiang, X, Yang, D, Chen, X, Jiang, Y, Jiang, H, Shen, J, Melcher, K, Wang, M, Xie, X, Xu, H.E. | | 登録日 | 2022-09-08 | | 公開日 | 2022-11-09 | | 最終更新日 | 2022-11-30 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Molecular recognition of morphine and fentanyl by the human mu-opioid receptor.
Cell, 185, 2022
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8EFQ
 | | DAMGO-bound mu-opioid receptor-Gi complex | | 分子名称: | DAMGO, ETHANOLAMINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Zhuang, Y, Wang, Y, Guo, S, Zhou, X.E, Rao, Q, He, X, He, B, Liu, J, Zhou, Q, Wang, X, Liu, W, Jiang, X, Yang, D, Chen, X, Jiang, Y, Jiang, H, Shen, J, Melcher, K, Wang, M, Xie, X, Xu, H.E. | | 登録日 | 2022-09-08 | | 公開日 | 2022-11-09 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Molecular recognition of morphine and fentanyl by the human mu-opioid receptor.
Cell, 185, 2022
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8EIT
 | | Structure of FFAR1-Gq complex bound to DHA | | 分子名称: | A modified Guanine nucleotide-binding protein G(q) subunit alpha, DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, Free fatty acid receptor 1, ... | | 著者 | Kumari, P, Inoue, A, Chapman, K, Lian, P, Rosenbaum, D.M. | | 登録日 | 2022-09-15 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-05-31 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Molecular mechanism of fatty acid activation of FFAR1.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8EJC
 | | Structure of FFAR1-Gq complex bound to TAK-875 | | 分子名称: | A modified Guanine nucleotide-binding protein G(q) subunit alpha, Free fatty acid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Kumari, P, Inoue, A, Chapman, K, Lian, P, Rosenbaum, D.M. | | 登録日 | 2022-09-16 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-05-31 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Molecular mechanism of fatty acid activation of FFAR1.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8EJK
 | | Structure of FFAR1-Gq complex bound to TAK-875 in a lipid nanodisc | | 分子名称: | A modified Guanine nucleotide-binding protein G(q) subunit alpha, Free fatty acid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Kumari, P, Inoue, A, Chapman, K, Lian, P, Rosenbaum, D.M. | | 登録日 | 2022-09-17 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-05-31 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Molecular mechanism of fatty acid activation of FFAR1.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8F7Q
 | | Gi bound mu-opioid receptor in complex with beta-endorphin | | 分子名称: | Beta-endorphin, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Wang, Y, Zhuang, Y, DiBerto, J.F, Zhou, X.E, Schmitz, G.P, Yuan, Q, Jain, M.K, Liu, W, Melcher, K, Jiang, Y, Roth, B.L, Xu, H.E. | | 登録日 | 2022-11-20 | | 公開日 | 2022-12-14 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | | 主引用文献 | Structures of the entire human opioid receptor family.
Cell, 186, 2023
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8F7R
 | | Gi bound mu-opioid receptor in complex with endomorphin | | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Wang, Y, Zhuang, Y, DiBerto, J.F, Zhou, X.E, Schmitz, G.P, Yuan, Q, Jain, M.K, Liu, W, Melcher, K, Jiang, Y, Roth, B.L, Xu, H.E. | | 登録日 | 2022-11-20 | | 公開日 | 2022-12-14 | | 最終更新日 | 2023-02-01 | | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | | 主引用文献 | Structures of the entire human opioid receptor family.
Cell, 186, 2023
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8F7S
 | | Gi bound delta-opioid receptor in complex with deltorphin | | 分子名称: | CHOLESTEROL, Delta-type opioid receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Wang, Y, Zhuang, Y, DiBerto, J.F, Zhou, X.E, Schmitz, G.P, Yuan, Q, Jain, M.K, Liu, W, Melcher, K, Jiang, Y, Roth, B.L, Xu, H.E. | | 登録日 | 2022-11-20 | | 公開日 | 2022-12-14 | | 最終更新日 | 2023-02-01 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structures of the entire human opioid receptor family.
Cell, 186, 2023
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8F7W
 | | Gi bound kappa-opioid receptor in complex with dynorphin | | 分子名称: | CHOLESTEROL, Dynorphin, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Wang, Y, Zhuang, Y, DiBerto, J.F, Zhou, X.E, Schmitz, G.P, Yuan, Q, Jain, M.K, Liu, W, Melcher, K, Jiang, Y, Roth, B.L, Xu, H.E. | | 登録日 | 2022-11-20 | | 公開日 | 2022-12-14 | | 最終更新日 | 2023-02-01 | | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | | 主引用文献 | Structures of the entire human opioid receptor family.
Cell, 186, 2023
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8F7X
 | | Gi bound nociceptin receptor in complex with nociceptin peptide | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Wang, Y, Zhuang, Y, DiBerto, J.F, Zhou, X.E, Schmitz, G.P, Yuan, Q, Jain, M.K, Liu, W, Melcher, K, Jiang, Y, Roth, B.L, Xu, H.E. | | 登録日 | 2022-11-20 | | 公開日 | 2022-12-14 | | 最終更新日 | 2023-02-01 | | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | | 主引用文献 | Structures of the entire human opioid receptor family.
Cell, 186, 2023
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8FCZ
 | | Crystal structure of ground-state rhodopsin in complex with a nanobody | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody Nb2, ... | | 著者 | Salom, D, Palczewski, K, Kiser, P.D. | | 登録日 | 2022-12-01 | | 公開日 | 2023-08-30 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | | 主引用文献 | Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain.
Nat Commun, 14, 2023
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8FD0
 | | Crystal structure of bovine rod opsin in complex with a nanobody | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody Nb2, ... | | 著者 | Salom, D, Palczewski, K, Kiser, P.D. | | 登録日 | 2022-12-01 | | 公開日 | 2023-08-30 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.71 Å) | | 主引用文献 | Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain.
Nat Commun, 14, 2023
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8FD1
 | | Crystal structure of photoactivated rhodopsin in complex with a nanobody | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody Nb2, ... | | 著者 | Salom, D, Palczewski, K, Kiser, P.D. | | 登録日 | 2022-12-01 | | 公開日 | 2023-08-30 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (4.25 Å) | | 主引用文献 | Structural basis for the allosteric modulation of rhodopsin by nanobody binding to its extracellular domain.
Nat Commun, 14, 2023
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8FEG
 | | CryoEM structure of Kappa Opioid Receptor bound to a semi-peptide and Gi1 | | 分子名称: | ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Fay, J.F, Che, T. | | 登録日 | 2022-12-06 | | 公開日 | 2023-12-06 | | 最終更新日 | 2024-01-17 | | 実験手法 | ELECTRON MICROSCOPY (2.54 Å) | | 主引用文献 | Design and structural validation of peptide-drug conjugate ligands of the kappa-opioid receptor.
Nat Commun, 14, 2023
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8FMZ
 | | Neurotensin receptor allosterism revealed in complex with a biased allosteric modulator | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, MiniGq, ... | | 著者 | Krumm, B.E, Diberto, J.F, Olsen, R.H.J, Kang, H, Slocum, S.T, Zhang, S, Strachan, R.T, Fay, J.F, Roth, B.L. | | 登録日 | 2022-12-26 | | 公開日 | 2023-03-29 | | 最終更新日 | 2023-04-19 | | 実験手法 | ELECTRON MICROSCOPY (2.59 Å) | | 主引用文献 | Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator.
Biochemistry, 62, 2023
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8FN0
 | | CryoEM structure of Go-coupled NTSR1 with a biased allosteric modulator | | 分子名称: | 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Krumm, B.E, DiBerto, J.F, Olsen, R.H.J, Kang, H, Slocum, S.T, Zhang, S, Strachan, R.T, Fay, J.F, Roth, B.L. | | 登録日 | 2022-12-26 | | 公開日 | 2023-03-29 | | 最終更新日 | 2023-04-19 | | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | | 主引用文献 | Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator.
Biochemistry, 62, 2023
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8FN1
 | | CryoEM structure of Go-coupled NTSR1 | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(o) subunit alpha, ... | | 著者 | Krumm, B.E, DiBerto, J.F, Olsen, R.H.J, Kang, H, Slocum, S.T, Zhang, S, Strachan, R.T, Fay, J.F, Roth, B.L. | | 登録日 | 2022-12-26 | | 公開日 | 2023-03-29 | | 最終更新日 | 2023-04-19 | | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | | 主引用文献 | Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator.
Biochemistry, 62, 2023
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8FX5
 | | Human M4 muscarinic acetylcholine receptor complex with Gi1 and xanomeline | | 分子名称: | Antibody fragment scFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Vuckovic, Z, Mobbs, J.I, Glukhova, A, Sexton, P.M, Danev, R, Thal, D.M. | | 登録日 | 2023-01-23 | | 公開日 | 2023-09-13 | | 実験手法 | ELECTRON MICROSCOPY (2.45 Å) | | 主引用文献 | Xanomeline displays concomitant orthosteric and allosteric binding modes at the M 4 mAChR.
Nat Commun, 14, 2023
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8FY8
 | | 5-MeO-DMT-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex | | 分子名称: | 2-(5-methoxy-1H-indol-3-yl)-N,N-dimethylethan-1-amine, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Warren, A.L, Zilberg, G, Capper, M.J, Wacker, D. | | 登録日 | 2023-01-25 | | 公開日 | 2024-05-15 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.79 Å) | | 主引用文献 | Structural pharmacology and therapeutic potential of 5-methoxytryptamines.
Nature, 630, 2024
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8FYE
 | | 4-F, 5-MeO-PyrT-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex | | 分子名称: | 4-fluoro-5-methoxy-3-[2-(pyrrolidin-1-yl)ethyl]-1H-indole, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Warren, A.L, Zilberg, G, Capper, M.J, Wacker, D. | | 登録日 | 2023-01-26 | | 公開日 | 2024-05-15 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | | 主引用文献 | Structural pharmacology and therapeutic potential of 5-methoxytryptamines.
Nature, 630, 2024
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8FYL
 | | Vilazodone-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex | | 分子名称: | 5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Warren, A.L, Zilberg, G, Capper, M.J, Wacker, D. | | 登録日 | 2023-01-26 | | 公開日 | 2024-05-15 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | | 主引用文献 | Structural pharmacology and therapeutic potential of 5-methoxytryptamines.
Nature, 630, 2024
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8FYN
 | | MicroED structure of A2A from plasma milled lamellae | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, ... | | 著者 | Martynowycz, M.W, Shiriaeva, A, Clabbers, M.T.B, Nicolas, W.J, Weaver, S.J, Hattne, J, Gonen, T. | | 登録日 | 2023-01-26 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-03-22 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (2 Å) | | 主引用文献 | A robust approach for MicroED sample preparation of lipidic cubic phase embedded membrane protein crystals.
Nat Commun, 14, 2023
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8FYT
 | | LSD-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex | | 分子名称: | (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Warren, A.L, Zilberg, G, Capper, M.J, Wacker, D. | | 登録日 | 2023-01-26 | | 公開日 | 2024-05-15 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | | 主引用文献 | Structural pharmacology and therapeutic potential of 5-methoxytryptamines.
Nature, 630, 2024
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8FYX
 | | Buspirone-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex | | 分子名称: | Buspirone, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Warren, A.L, Zilberg, G, Capper, M.J, Wacker, D. | | 登録日 | 2023-01-26 | | 公開日 | 2024-05-15 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.62 Å) | | 主引用文献 | Structural pharmacology and therapeutic potential of 5-methoxytryptamines.
Nature, 630, 2024
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8G05
 | | Cryo-EM structure of an orphan GPCR-Gi protein signaling complex | | 分子名称: | 6-(octylamino)pyrimidine-2,4(3H,5H)-dione, CHOLESTEROL, G-protein coupled receptor 84, ... | | 著者 | Zhang, X, Wang, Y.J, Li, X, Liu, G.B, Gong, W.M, Zhang, C. | | 登録日 | 2023-01-31 | | 公開日 | 2023-11-01 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Pro-phagocytic function and structural basis of GPR84 signaling.
Nat Commun, 14, 2023
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