8AW2
 
 | | Mouse serotonin 5-HT3A receptor in complex with vortioxetine | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, ... | | 著者 | Lopez-Sanchez, U, Nury, H. | | 登録日 | 2022-08-29 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | | 主引用文献 | Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT 3 receptors.
Nat.Struct.Mol.Biol., 2024
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8AXD
 | | Human serotonin 5-HT3A receptor (apo, resting conformation) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A | | 著者 | Lopez-Sanchez, U, Nury, H. | | 登録日 | 2022-08-31 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | | 主引用文献 | Structural determinants for activity of the antidepressant vortioxetine at human and rodent 5-HT 3 receptors.
Nat.Struct.Mol.Biol., 2024
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2I4B
 | | Crystal structure of Bicarbonate Transport Protein CmpA from Synechocystis sp. PCC 6803 in complex with bicarbonate and calcium | | 分子名称: | BICARBONATE ION, Bicarbonate transporter, CALCIUM ION | | 著者 | Koropatkin, N.M, Smith, T.J, Pakrasi, H.B. | | 登録日 | 2006-08-21 | | 公開日 | 2006-12-19 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | The Structure of a Cyanobacterial Bicarbonate Transport Protein, CmpA.
J.Biol.Chem., 282, 2007
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2IBF
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2H9X
 | | NMR structure for the CgNa toxin from the sea anemone Condylactis gigantea | | 分子名称: | Toxin CgNa | | 著者 | Lopez-Mendez, B, Perez-Castells, J, Gimenez-Gallego, G, Jimenez-Barbero, J. | | 登録日 | 2006-06-12 | | 公開日 | 2007-06-05 | | 最終更新日 | 2022-03-09 | | 実験手法 | SOLUTION NMR | | 主引用文献 | CgNa, a type I toxin from the giant Caribbean sea anemone Condylactis gigantea shows structural similarities to both type I and II toxins, as well as distinctive structural and functional properties(1).
Biochem.J., 406, 2007
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2LKB
 | | Evolutionary diversification of Mesobuthus alpha-scorpion toxins affecting sodium channels | | 分子名称: | Neurotoxin MeuNaTx-5 | | 著者 | Zhu, S, Peigneur, S, Gao, B, Lu, X, Cao, C, Tytgat, J. | | 登録日 | 2011-10-09 | | 公開日 | 2011-11-02 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Evolutionary diversification of Mesobuthus {alpha}-scorpion toxins affecting sodium channels
Mol.Cell Proteomics, 2011
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2CWW
 | | Crystal structure of Thermus thermophilus TTHA1280, a putative SAM-dependent RNA methyltransferase, in complex with S-adenosyl-L-homocysteine | | 分子名称: | ACETIC ACID, GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE, ... | | 著者 | Pioszak, A.A, Murayama, K, Nakagawa, N, Ebihara, A, Kuramitsu, S, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2005-06-27 | | 公開日 | 2005-10-11 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structures of a putative RNA 5-methyluridine methyltransferase, Thermus thermophilus TTHA1280, and its complex with S-adenosyl-L-homocysteine.
Acta Crystallogr.,Sect.F, 61, 2005
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6KF3
 | | Cryo-EM structure of Thermococcus kodakarensis RNA polymerase | | 分子名称: | DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit A'', DNA-directed RNA polymerase subunit D, ... | | 著者 | Jun, S.-H, Hyun, J, Jeong, H, Cha, J.S, Kim, H, Bartlett, M.S, Cho, H.-S, Murakami, K.S. | | 登録日 | 2019-07-06 | | 公開日 | 2020-07-01 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Direct binding of TFE alpha opens DNA binding cleft of RNA polymerase.
Nat Commun, 11, 2020
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8JV7
 | | Cryo-EM structure of the panda P2X7 receptor in complex with PPADS | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(E)-[4-methanoyl-6-methyl-5-oxidanyl-3-(phosphonooxymethyl)pyridin-2-yl]diazenyl]benzene-1,3-disulfonic acid, P2X purinoceptor | | 著者 | Sheng, D, Hattori, M. | | 登録日 | 2023-06-27 | | 公開日 | 2023-11-29 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural insights into the orthosteric inhibition of P2X receptors by non-ATP analog antagonists.
Elife, 12, 2024
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8JV8
 | | Cryo-EM structure of the panda P2X7 receptor in complex with PPNDS | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]-7-nitronaphthalene-1,5-disulfonic acid, P2X purinoceptor | | 著者 | Sheng, D, Hattori, M. | | 登録日 | 2023-06-27 | | 公開日 | 2023-11-29 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.34 Å) | | 主引用文献 | Structural insights into the orthosteric inhibition of P2X receptors by non-ATP analog antagonists.
Elife, 12, 2024
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6KF4
 | | Cryo-EM structure of Thermococcus kodakarensis RNA polymerase | | 分子名称: | DNA-directed RNA polymerase subunit, DNA-directed RNA polymerase subunit A'', DNA-directed RNA polymerase subunit D, ... | | 著者 | Jun, S.-H, Hyun, J, Jeong, H, Cha, J.S, Kim, H, Bartlett, M.S, Cho, H.-S, Murakami, K.S. | | 登録日 | 2019-07-06 | | 公開日 | 2020-07-01 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.97 Å) | | 主引用文献 | Direct binding of TFE alpha opens DNA binding cleft of RNA polymerase.
Nat Commun, 11, 2020
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8QTL
 | | Aplysia californica acetylcholine-binding protein in complex with Spiroimine (-)-4 S | | 分子名称: | CHLORIDE ION, ISOPROPYL ALCOHOL, Soluble acetylcholine receptor, ... | | 著者 | Sulzenbacher, G, Bourne, Y, Marchot, P. | | 登録日 | 2023-10-12 | | 公開日 | 2024-04-03 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | The Cyclic Imine Core Common to the Marine Macrocyclic Toxins Is Sufficient to Dictate Nicotinic Acetylcholine Receptor Antagonism.
Mar Drugs, 22, 2024
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8QX2
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8Q1M
 | | Aplysia californica acetylcholine-binding protein in complex with Spiroimine (+)-4 R | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Soluble acetylcholine receptor, ... | | 著者 | Sulzenbacher, G, Bourne, Y, Marchot, P. | | 登録日 | 2023-07-31 | | 公開日 | 2024-04-03 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The Cyclic Imine Core Common to the Marine Macrocyclic Toxins Is Sufficient to Dictate Nicotinic Acetylcholine Receptor Antagonism.
Mar Drugs, 22, 2024
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8SLY
 | | Rat TRPV2 bound with 2 CBD ligands in nanodiscs | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 2, ... | | 著者 | Tan, X, Swartz, K.J. | | 登録日 | 2023-04-24 | | 公開日 | 2023-05-31 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | | 主引用文献 | Cannabidiol sensitizes TRPV2 channels to activation by 2-APB.
Elife, 12, 2023
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8SLX
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2AYA
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2AXK
 | | Solution structure of discrepin, a scorpion venom toxin blocking K+ channels. | | 分子名称: | discrepin | | 著者 | Prochnicka-Chalufour, A, Corzo, G, Satake, H, Martin-Eauclaire, M.-F, Murgia, A.R, Prestipino, G, D'Suze, G, Possani, L.D, Delepierre, M. | | 登録日 | 2005-09-05 | | 公開日 | 2006-06-20 | | 最終更新日 | 2019-12-25 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of discrepin, a new K+-channel blocking peptide from the alpha-KTx15 subfamily.
Biochemistry, 45, 2006
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8SEM
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2AL4
 | | CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH quisqualate and CX614. | | 分子名称: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, 2,3,6A,7,8,9-HEXAHYDRO-11H-[1,4]DIOXINO[2,3-G]PYRROLO[2,1-B][1,3]BENZOXAZIN-11-ONE, Glutamate receptor 2, ... | | 著者 | Jin, R, Clark, S, Weeks, A.M, Dudman, J.T, Gouaux, E, Partin, K.M. | | 登録日 | 2005-08-04 | | 公開日 | 2005-10-25 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Mechanism of positive allosteric modulators acting on AMPA receptors.
J.Neurosci., 25, 2005
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4U1D
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3EHT
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3EHS
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5EYO
 | | The crystal structure of the Max bHLH domain in complex with 5-carboxyl cytosine DNA | | 分子名称: | DNA (5'-D(*AP*GP*TP*AP*GP*CP*AP*(1CC)P*GP*TP*GP*CP*TP*AP*CP*T)-3'), Protein max | | 著者 | Wang, D, Hashimoto, H, Zhang, X, Cheng, X. | | 登録日 | 2015-11-25 | | 公開日 | 2016-12-14 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | MAX is an epigenetic sensor of 5-carboxylcytosine and is altered in multiple myeloma.
Nucleic Acids Res., 45, 2017
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5FJ8
 | | Cryo-EM structure of yeast RNA polymerase III elongation complex at 3. 9 A | | 分子名称: | DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC1, DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10, DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC2, ... | | 著者 | Hoffmann, N.A, Jakobi, A.J, Moreno-Morcillo, M, Glatt, S, Kosinski, J, Hagen, W.J, Sachse, C, Muller, C.W. | | 登録日 | 2015-10-06 | | 公開日 | 2015-11-25 | | 最終更新日 | 2017-08-30 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Molecular Structures of Unbound and Transcribing RNA Polymerase III.
Nature, 528, 2015
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