PDB: 13258 件ウェブページステータス検索Chemie searchBIRD

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7K19	CryoEM structure of DNA-PK catalytic subunit complexed with DNA (Complex I) 分子名称: DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*AP*TP*GP*C)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), DNA-dependent protein kinase catalytic subunit 著者 Chen, X, Gellert, M, Yang, W. 登録日 2020-09-07 公開日 2021-01-06 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Structure of an activated DNA-PK and its implications for NHEJ. Mol.Cell, 81, 2021
7K1J	CryoEM structure of inactivated-form DNA-PK (Complex III) 分子名称: DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*A)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), DNA-dependent protein kinase catalytic subunit, ... 著者 Chen, X, Gellert, M, Yang, W. 登録日 2020-09-07 公開日 2021-01-06 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structure of an activated DNA-PK and its implications for NHEJ. Mol.Cell, 81, 2021
5WVK	Yeast proteasome-ADP-AlFx 分子名称: 26S protease regulatory subunit 4 homolog, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B homolog, ... 著者 Ding, Z, Cong, Y. 登録日 2016-12-25 公開日 2017-03-22 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 High-resolution cryo-EM structure of the proteasome in complex with ADP-AlFx Cell Res., 27, 2017
5D3G	Structure of HIV-1 Reverse Transcriptase Bound to a Novel 38-mer Hairpin Template-Primer DNA Aptamer 分子名称: DNA aptamer (38-MER), GLYCEROL, HIV-1 REVERSE TRANSCRIPTASE P51 subunit, ... 著者 Miller, M.T, Tuske, S, Das, K, Arnold, E. 登録日 2015-08-06 公開日 2015-09-30 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of HIV-1 reverse transcriptase bound to a novel 38-mer hairpin template-primer DNA aptamer. Protein Sci., 25, 2016
5WVI	The resting state of yeast proteasome 分子名称: 26S protease regulatory subunit 4 homolog, 26S protease regulatory subunit 6A, 26S protease regulatory subunit 6B homolog, ... 著者 Ding, Z, Cong, Y. 登録日 2016-12-25 公開日 2017-03-22 最終更新日 2019-10-23 実験手法 ELECTRON MICROSCOPY (6.3 Å) 主引用文献 High-resolution cryo-EM structure of the proteasome in complex with ADP-AlFx Cell Res., 27, 2017
7K1N	CryoEM structure of inactivated-form DNA-PK (Complex V) 分子名称: DNA (5'-D(P*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*A)-3'), DNA (5'-D(P*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), DNA-dependent protein kinase catalytic subunit, ... 著者 Chen, X, Gellert, M, Yang, W. 登録日 2020-09-08 公開日 2021-01-06 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structure of an activated DNA-PK and its implications for NHEJ. Mol.Cell, 81, 2021
5ZBB	Crystal structure of Rtt109-Asf1-H3-H4 complex 分子名称: DI(HYDROXYETHYL)ETHER, DNA damage response protein Rtt109, putative, ... 著者 Zhang, L, Serra-Cardona, A, Zhou, H, Wang, M, Yang, N, Zhang, Z, Xu, R.M. 登録日 2018-02-10 公開日 2018-07-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Multisite Substrate Recognition in Asf1-Dependent Acetylation of Histone H3 K56 by Rtt109. Cell, 174, 2018
7OWG	human DEPTOR in a complex with mutant human mTORC1 A1459P 分子名称: DEP domain-containing mTOR-interacting protein, Regulatory-associated protein of mTOR, Serine/threonine-protein kinase mTOR, ... 著者 Heimhalt, M, Berndt, A, Wagstaff, J, Anandapadamanaban, M, Perisic, O, Maslen, S, McLaughlin, S, Yu, W.-H, Masson, G.R, Boland, A, Ni, X, Yamashita, K, Murshudov, G.N, Skehel, M, Freund, S.M, Williams, R.L. 登録日 2021-06-18 公開日 2021-09-08 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (4.7 Å) 主引用文献 Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace. Elife, 10, 2021
7K1K	CryoEM structure of inactivated-form DNA-PK (Complex IV) 分子名称: DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*A)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), DNA-dependent protein kinase catalytic subunit, ... 著者 Chen, X, Gellert, M, Yang, W. 登録日 2020-09-07 公開日 2021-01-06 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Structure of an activated DNA-PK and its implications for NHEJ. Mol.Cell, 81, 2021
3ZRC	pVHL54-213-EloB-EloC complex (4R)-4-HYDROXY-1-[(3-METHYLISOXAZOL-5-YL)ACETYL]-N-[4-(1,3-OXAZOL-5-YL)BENZYL]-L-PROLINAMIDE bound 分子名称: (4R)-4-HYDROXY-1-[(3-METHYLISOXAZOL-5-YL)ACETYL]-N-[4-(1,3-OXAZOL-5-YL)BENZYL]-L-PROLINAMIDE, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2, ... 著者 Van Molle, I, Buckley, D.L, Crews, C.M, Ciulli, A. 登録日 2011-06-15 公開日 2012-03-07 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Targeting the Von Hippel-Lindau E3 Ubiquitin Ligase Using Small Molecules to Disrupt the Vhl/Hif-1Alpha Interaction J.Am.Chem.Soc., 134, 2012
5HRO	STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE In COMPLEX WITH A DNA aptamer and an Alpha-carboxy nucleoside phosphonate inhibitor (alpha-CNP) 分子名称: DNA (38-MER), HIV-1 REVERSE TRANSCRIPTASE P51 SUBUNIT, HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT, ... 著者 Das, K, Arnold, E. 登録日 2016-01-23 公開日 2016-06-01 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis-Binding of Foscarnet. Acs Chem.Biol., 11, 2016
3ZRF	pVHL54-213-EloB-EloC complex_apo 分子名称: TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2, VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR, 著者 Van Molle, I, Buckley, D.L, Crews, C.M, Ciulli, A. 登録日 2011-06-16 公開日 2012-03-07 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Targeting the Von Hippel-Lindau E3 Ubiquitin Ligase Using Small Molecules to Disrupt the Vhl/Hif-1Alpha Interaction J.Am.Chem.Soc., 134, 2012
6O9O	Crystal Structure of SMYD3 with Potent and Selective Isoxazole Amide Inhibitor 1 分子名称: 5-cyclopropyl-N-{1-[({trans-4-[(4,4,4-trifluorobutyl)amino]cyclohexyl}methyl)sulfonyl]piperidin-4-yl}-1,2-oxazole-3-carboxamide, GLYCEROL, Histone-lysine N-methyltransferase SMYD3, ... 著者 Elkins, P.A, Wang, L. 登録日 2019-03-14 公開日 2020-03-18 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.586 Å) 主引用文献 Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors To be published
3HVT	STRUCTURAL BASIS OF ASYMMETRY IN THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE HETERODIMER 分子名称: 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, HIV-1 REVERSE TRANSCRIPTASE (SUBUNIT P51), HIV-1 REVERSE TRANSCRIPTASE (SUBUNIT P66) 著者 Steitz, T.A, Smerdon, S.J, Jaeger, J, Wang, J, Kohlstaedt, L.A, Chirino, A.J, Friedman, J.M, Rice, P.A. 登録日 1994-07-25 公開日 1994-10-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1. Proc.Natl.Acad.Sci.Usa, 91, 1994
8H2H	Cryo-EM structure of a Group II Intron Complexed with its Reverse Transcriptase 分子名称: Group II intron-encoded protein LtrA, LtrB, RNA (5'-R(P*CP*AP*CP*AP*UP*CP*CP*AP*UP*AP*AP*C)-3') 著者 Liu, N, Dong, X.L, Qu, G.S, Wang, J, Wang, H.W, Belfort, M. 登録日 2022-10-06 公開日 2022-11-23 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Functionalized graphene grids with various charges for single-particle cryo-EM. Nat Commun, 13, 2022
6P6G	Co-crystal Structure of human SMYD3 with Isoxazole Amides Inhibitors 分子名称: 5-cyclopropyl-N-{1-[({trans-4-[(4,4,4-trifluorobutyl)amino]cyclohexyl}methyl)sulfonyl]piperidin-4-yl}-1,2-oxazole-3-carboxamide, GLYCEROL, Histone-lysine N-methyltransferase SMYD3, ... 著者 Elkins, P.A, Wang, L. 登録日 2019-06-03 公開日 2020-01-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors. Acs Med.Chem.Lett., 11, 2020
6P6K	Co-crystal Structure of human SMYD3 with Isoxazole Amides Inhibitors 分子名称: 1,2-ETHANEDIOL, Histone-lysine N-methyltransferase SMYD3, MAGNESIUM ION, ... 著者 Elkins, P.A, Wang, L. 登録日 2019-06-04 公開日 2020-01-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors. Acs Med.Chem.Lett., 11, 2020
7NTF	Cryo-EM structure of unliganded O-GlcNAc transferase 分子名称: Isoform 1 of UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 著者 Meek, R.W, Blaza, J.N, Davies, G.J. 登録日 2021-03-09 公開日 2021-11-17 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (5.32 Å) 主引用文献 Cryo-EM structure provides insights into the dimer arrangement of the O-linked beta-N-acetylglucosamine transferase OGT. Nat Commun, 12, 2021
7UX2	cryo-EM structure of the Raptor-TFEB-Rag-Ragulator complex 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... 著者 Cui, Z, Hurley, J. 登録日 2022-05-04 公開日 2022-11-30 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex. Nature, 614, 2023
6P7Z	Co-crystal Structure of human SMYD3 with Isoxazole Amides Inhibitors 分子名称: 5-cyclopropyl-N-[1-(methylsulfonyl)piperidin-4-yl]-1,2-oxazole-3-carboxamide, Histone-lysine N-methyltransferase SMYD3, MAGNESIUM ION, ... 著者 Elkins, P.A, Bonnette, W.G. 登録日 2019-06-06 公開日 2020-01-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.19 Å) 主引用文献 Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors. Acs Med.Chem.Lett., 11, 2020
4WZS	Crystal structure of the Mot1 N-terminal domain in complex with TBP and NC2 bound to a promoter DNA fragment 分子名称: DNA (5'-D(P*CP*CP*AP*CP*CP*CP*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*CP*CP*CP*T)-3'), DNA (5'-D(P*GP*GP*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*GP*GP*GP*GP*TP*GP*G)-3'), ECU04_1440 protein, ... 著者 Butryn, A, Hopfner, K.-P. 登録日 2014-11-20 公開日 2015-08-26 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.78 Å) 主引用文献 Structural basis for recognition and remodeling of the TBP:DNA:NC2 complex by Mot1. Elife, 4, 2015
6PAF	Co-crystal Structure of human SMYD3 with Isoxazole Amides Inhibitors 分子名称: GLYCEROL, Histone-lysine N-methyltransferase SMYD3, MAGNESIUM ION, ... 著者 Elkins, P.A, Wang, L. 登録日 2019-06-11 公開日 2020-01-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.241 Å) 主引用文献 Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors. Acs Med.Chem.Lett., 11, 2020
3BAP	Crystal Structure of the 25 kDa Subunit of Human Cleavage Factor Im 分子名称: Cleavage and polyadenylation specificity factor subunit 5, GLYCEROL 著者 Coseno, M, Doublie, S. 登録日 2007-11-08 公開日 2008-02-19 最終更新日 2018-01-24 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Crystal structure of the 25 kDa subunit of human cleavage factor Im. Nucleic Acids Res., 36, 2008
5LQF	CDK1/CyclinB1/CKS2 in complex with NU6102 分子名称: Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 2, G2/mitotic-specific cyclin-B1, ... 著者 Coxon, C.R, Anscombe, E, Harnor, S.J, Martin, M.P, Carbain, B.J, Hardcastle, I.R, Harlow, L.K, Korolchuk, S, Matheson, C.J, Noble, M.E, Newell, D.R, Turner, D.M, Sivaprakasam, M, Wang, L.Z, Wong, C, Golding, B.T, Griffin, R.J, Endicott, J.A, Cano, C. 登録日 2016-08-17 公開日 2017-01-11 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines. J. Med. Chem., 60, 2017
6ZFP	Cryo-EM structure of DNA-PKcs (State 2) 分子名称: DNA-dependent protein kinase catalytic subunit,DNA-PKcs,DNA-PKcs 著者 Chaplin, A.K, Hardwick, S.W, Chirgadze, D.Y, Blundell, T.L. 登録日 2020-06-17 公開日 2020-10-21 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.24 Å) 主引用文献 Dimers of DNA-PK create a stage for DNA double-strand break repair. Nat.Struct.Mol.Biol., 28, 2021

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