7K19

CryoEM structure of DNA-PK catalytic subunit complexed with DNA (Complex I)

Summary for 7K19

• Entry DOI: 10.2210/pdb7k19/pdb
• Related: 7K0Y
• EMDB information: 22618 22622
• Descriptor: DNA-dependent protein kinase catalytic subunit, DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*AP*TP*GP*C)-3') (3 entities in total)
• Functional Keywords: nhej, v(d)j recombination, dna repair, dna binding protein, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 489252.89

Authors

Chen, X.,Gellert, M.,Yang, W. (deposition date: 2020-09-07, release date: 2021-01-06, Last modification date: 2024-03-06)

• Primary citation: Chen, X.,Xu, X.,Chen, Y.,Cheung, J.C.,Wang, H.,Jiang, J.,de Val, N.,Fox, T.,Gellert, M.,Yang, W.; Structure of an activated DNA-PK and its implications for NHEJ.; Mol.Cell, 81:801-810.e3, 2021; PubMed: 33385326; DOI: 10.1016/j.molcel.2020.12.015

Experimental method

ELECTRON MICROSCOPY (4.3 Å)