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5HRO

STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE In COMPLEX WITH A DNA aptamer and an Alpha-carboxy nucleoside phosphonate inhibitor (alpha-CNP)

Summary for 5HRO
Entry DOI10.2210/pdb5hro/pdb
Related4R5P 5D3G 5HLF 5HP1 5HRO
Related PRD IDPRD_900003
DescriptorHIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT, HIV-1 REVERSE TRANSCRIPTASE P51 SUBUNIT, DNA (38-MER), ... (8 entities in total)
Functional Keywordsrt, dna aptamer, ncrti, nucleotide-competing rt inhibitor, 2-o-methylcytidine, p51, p66, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHuman immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)
More
Total number of polymer chains6
Total formula weight257235.89
Authors
Das, K.,Arnold, E. (deposition date: 2016-01-23, release date: 2016-06-01, Last modification date: 2023-09-27)
Primary citationDas, K.,Balzarini, J.,Miller, M.T.,Maguire, A.R.,DeStefano, J.J.,Arnold, E.
Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis-Binding of Foscarnet.
Acs Chem.Biol., 11:2158-2164, 2016
Cited by
PubMed: 27192549
DOI: 10.1021/acschembio.6b00187
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.75 Å)
Structure validation

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