4R5P

Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and a nucleoside triphosphate mimic alpha-carboxy nucleoside phosphonate inhibitor

Summary for 4R5P

• Entry DOI: 10.2210/pdb4r5p/pdb
• Related: 3V4I
• Related PRD ID: PRD_900003
• Descriptor: HIV-1 reverse transcriptase, p66 subunit, HIV-1 reverse transcriptase, p51 subunit, 5'-D(*TP*GP*GP*AP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3', ... (9 entities in total)
• Functional Keywords: zidovudine, rt-dna complex, aids, dna-directed dna polymerase, rn lipoprotein, hiv, metal-binding, alpha-cnp, ribonuclease h, rnase h, a-cnp, multifunctional enzyme, nucleotidyltransferase, rna-directed polymerase, transferase, hydrolase-dna-inhibitor complex, hydrolase/dna/inhibitor
• Biological source: Human immunodeficiency virus type 1 (HIV-1); More
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366
• Total number of polymer chains: 8
• Total formula weight: 259540.17

Authors

Das, K.,Martinez, S.E.,Arnold, E. (deposition date: 2014-08-21, release date: 2015-03-11, Last modification date: 2023-09-20)

• Primary citation: Balzarini, J.,Das, K.,Bernatchez, J.A.,Martinez, S.E.,Ngure, M.,Keane, S.,Ford, A.,Maguire, N.,Mullins, N.,John, J.,Kim, Y.,Dehaen, W.,Vande Voorde, J.,Liekens, S.,Naesens, L.,Gotte, M.,Maguire, A.R.,Arnold, E.; Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics.; Proc.Natl.Acad.Sci.USA, 112:3475-3480, 2015; PubMed: 25733891; DOI: 10.1073/pnas.1420233112

Experimental method

X-RAY DIFFRACTION (2.894 Å)