4R5P
Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and a nucleoside triphosphate mimic alpha-carboxy nucleoside phosphonate inhibitor
Summary for 4R5P
Entry DOI | 10.2210/pdb4r5p/pdb |
Related | 3V4I |
Related PRD ID | PRD_900003 |
Descriptor | HIV-1 reverse transcriptase, p66 subunit, HIV-1 reverse transcriptase, p51 subunit, 5'-D(*TP*GP*GP*AP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3', ... (9 entities in total) |
Functional Keywords | zidovudine, rt-dna complex, aids, dna-directed dna polymerase, rn lipoprotein, hiv, metal-binding, alpha-cnp, ribonuclease h, rnase h, a-cnp, multifunctional enzyme, nucleotidyltransferase, rna-directed polymerase, transferase, hydrolase-dna-inhibitor complex, hydrolase/dna/inhibitor |
Biological source | Human immunodeficiency virus type 1 (HIV-1) More |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366 |
Total number of polymer chains | 8 |
Total formula weight | 259540.17 |
Authors | Das, K.,Martinez, S.E.,Arnold, E. (deposition date: 2014-08-21, release date: 2015-03-11, Last modification date: 2023-09-20) |
Primary citation | Balzarini, J.,Das, K.,Bernatchez, J.A.,Martinez, S.E.,Ngure, M.,Keane, S.,Ford, A.,Maguire, N.,Mullins, N.,John, J.,Kim, Y.,Dehaen, W.,Vande Voorde, J.,Liekens, S.,Naesens, L.,Gotte, M.,Maguire, A.R.,Arnold, E. Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics. Proc.Natl.Acad.Sci.USA, 112:3475-3480, 2015 Cited by PubMed: 25733891DOI: 10.1073/pnas.1420233112 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.894 Å) |
Structure validation
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