5HRO
STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE In COMPLEX WITH A DNA aptamer and an Alpha-carboxy nucleoside phosphonate inhibitor (alpha-CNP)
Summary for 5HRO
Entry DOI | 10.2210/pdb5hro/pdb |
Related | 4R5P 5D3G 5HLF 5HP1 5HRO |
Related PRD ID | PRD_900003 |
Descriptor | HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT, HIV-1 REVERSE TRANSCRIPTASE P51 SUBUNIT, DNA (38-MER), ... (8 entities in total) |
Functional Keywords | rt, dna aptamer, ncrti, nucleotide-competing rt inhibitor, 2-o-methylcytidine, p51, p66, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) More |
Total number of polymer chains | 6 |
Total formula weight | 257235.89 |
Authors | Das, K.,Arnold, E. (deposition date: 2016-01-23, release date: 2016-06-01, Last modification date: 2023-09-27) |
Primary citation | Das, K.,Balzarini, J.,Miller, M.T.,Maguire, A.R.,DeStefano, J.J.,Arnold, E. Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis-Binding of Foscarnet. Acs Chem.Biol., 11:2158-2164, 2016 Cited by PubMed: 27192549DOI: 10.1021/acschembio.6b00187 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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