5HRO
STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE In COMPLEX WITH A DNA aptamer and an Alpha-carboxy nucleoside phosphonate inhibitor (alpha-CNP)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, C) | HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT | polymer | 555 | 63875.1 | 2 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) | Pr160Gag-Pol |
| 2 | B, E (B, D) | HIV-1 REVERSE TRANSCRIPTASE P51 SUBUNIT | polymer | 444 | 51928.6 | 2 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) | Pr160Gag-Pol |
| 3 | C, F (E, F) | DNA (38-MER) | polymer | 38 | 11748.5 | 2 | synthetic construct | ||
| 4 | G, H (G, H) | beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | branched | 342.3 | 2 | In PDB BIRD (PRD_900003) | sucrose | ||
| 5 | I, J, L, R, S... (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 6 | Chemie (MG) | |||
| 6 | K, V (A, F) | [(1R)-2-methoxy-1-{[(1S,3R)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)cyclopentyl]oxy}-2-oxoethyl]phosphonic acid | non-polymer | 362.3 | 2 | Chemie (3JY) | |||
| 7 | M, N, O, P, Q... (A, B, C) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 8 | W, X, Y (A, B, C) | water | water | 18.0 | 5 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 555 (UniProt: P03366)
B, D: 1 - 428 (UniProt: P03366)
| PDB | External Database | Details |
|---|---|---|
| Ser 280 | Cys 879 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met -15 | - | initiating methionine |
| Ala -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| Ala -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Glu -5 | - | expression tag |
| Val -4 | - | expression tag |
| Leu -3 | - | expression tag |
| Phe -2 | - | expression tag |
| Gln -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ser 280 | Cys 879 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 255104.5 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 684.6 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1446.8 | |
| All* | Total formula weight | 257235.9 |
