8W8E
| human co-transcriptional RNA capping enzyme RNGTT | 分子名称: | DNA (36-MER), DNA (45-MER), DNA-directed RNA polymerase II subunit E, ... | 著者 | Li, Y, Wang, Q, Xu, Y, Li, Z. | 登録日 | 2023-09-02 | 公開日 | 2024-04-10 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structures of co-transcriptional RNA capping enzymes on paused transcription complex. Nat Commun, 15, 2024
|
|
3I3L
| Crystal structure of CmlS, a flavin-dependent halogenase | 分子名称: | Alkylhalidase CmlS, FLAVIN-ADENINE DINUCLEOTIDE | 著者 | Podzelinska, K, Soares, A, Jia, Z, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | 登録日 | 2009-06-30 | 公開日 | 2010-03-09 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Chloramphenicol Biosynthesis: The Structure of CmlS, a Flavin-Dependent Halogenase Showing a Covalent Flavin-Aspartate Bond J.Mol.Biol., 397, 2010
|
|
8X7P
| CCA-bound E46K alpha-synuclein fibrils | 分子名称: | Alpha-synuclein, copper;trisodium;18-(2-carboxylatoethyl)-20-(carboxylatomethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-17,18-dihydroporphyrin-21,23-diide-2-carboxylate | 著者 | Liu, K.E, Tao, Y.Q, Li, D, Liu, C. | 登録日 | 2023-11-24 | 公開日 | 2024-09-11 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Binding adaptability of chemical ligands to polymorphic alpha-synuclein amyloid fibrils. Proc.Natl.Acad.Sci.USA, 121, 2024
|
|
8X7M
| CR-bound E46K alpha-synuclein fibrils | 分子名称: | 4-azanyl-3-[(~{E})-[4-[4-[(~{E})-(1-azanyl-4-sulfo-naphthalen-2-yl)diazenyl]phenyl]phenyl]diazenyl]naphthalene-1-sulfonic acid, Alpha-synuclein | 著者 | Liu, K.E, Tao, Y.Q, Li, D, Liu, C. | 登録日 | 2023-11-24 | 公開日 | 2024-09-11 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Binding adaptability of chemical ligands to polymorphic alpha-synuclein amyloid fibrils. Proc.Natl.Acad.Sci.USA, 121, 2024
|
|
8X7R
| C05-03-bound E46K alpha-synuclein fibrils | 分子名称: | 2-[(~{E})-4-[6-(methylamino)pyridin-3-yl]but-1-en-3-ynyl]-1,3-benzothiazol-6-ol, Alpha-synuclein | 著者 | Liu, K.E, Tao, Y.Q, Li, D, Liu, C. | 登録日 | 2023-11-24 | 公開日 | 2024-09-11 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Binding adaptability of chemical ligands to polymorphic alpha-synuclein amyloid fibrils. Proc.Natl.Acad.Sci.USA, 121, 2024
|
|
8X7Q
| pFTAA-bound E46K alpha-synuclein fibrils | 分子名称: | 3''',4'-bis(carboxymethyl)-2,2':5',2'':5'',2''':5''',2''''-quinquethiophene-5,5''''-dicarboxylic acid, Alpha-synuclein | 著者 | Liu, K.E, Tao, Y.Q, Li, D, Liu, C. | 登録日 | 2023-11-24 | 公開日 | 2024-09-11 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Binding adaptability of chemical ligands to polymorphic alpha-synuclein amyloid fibrils. Proc.Natl.Acad.Sci.USA, 121, 2024
|
|
8X7L
| EB-bound E46K alpha-synuclein fibrils | 分子名称: | 4-azanyl-6-[[4-[4-[(~{E})-(8-azanyl-1-oxidanyl-5,7-disulfo-naphthalen-2-yl)diazenyl]-3-methyl-phenyl]-2-methyl-phenyl]diazenyl]-5-oxidanyl-naphthalene-1,3-disulfonic acid, Alpha-synuclein | 著者 | Liu, K.E, Tao, Y.Q, Li, D, Liu, C. | 登録日 | 2023-11-24 | 公開日 | 2024-09-11 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Binding adaptability of chemical ligands to polymorphic alpha-synuclein amyloid fibrils. Proc.Natl.Acad.Sci.USA, 121, 2024
|
|
8X7O
| PiB-bound E46K mutanted alpha-synuclein fibrils | 分子名称: | 2-[4-(methylamino)phenyl]-1,3-benzothiazol-6-ol, Alpha-synuclein | 著者 | Liu, K.E, Tao, Y.Q, Li, D, Liu, C. | 登録日 | 2023-11-24 | 公開日 | 2024-09-11 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Binding adaptability of chemical ligands to polymorphic alpha-synuclein amyloid fibrils. Proc.Natl.Acad.Sci.USA, 121, 2024
|
|
3I3I
| |
3I03
| Crystal structure of bothropstoxin-I chemically modified by p-bromophenacyl bromide (BPB) - monomeric form at a high resolution | 分子名称: | ISOPROPYL ALCOHOL, Phospholipase A2 homolog bothropstoxin-1, p-Bromophenacyl bromide | 著者 | Marchi-Salvador, D.P, Fernandes, C.A.H, Soares, A.M, Fontes, M.R.M. | 登録日 | 2009-06-24 | 公開日 | 2010-05-12 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Comparison between apo and complexed structures of bothropstoxin-I reveals the role of Lys122 and Ca(2+)-binding loop region for the catalytically inactive Lys49-PLA(2)s. J.Struct.Biol., 171, 2010
|
|
3ZTQ
| Hexagonal crystal form P61 of the Aquifex aeolicus nucleoside diphosphate kinase | 分子名称: | NUCLEOSIDE DIPHOSPHATE KINASE | 著者 | Boissier, F, Georgescauld, F, Moynie, L, Dupuy, J.-W, Sarger, C, Podar, M, Lascu, I, Giraud, M.-F, Dautant, A. | 登録日 | 2011-07-12 | 公開日 | 2012-02-29 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | An Inter-Subunit Disulphide Bridge Stabilizes the Tetrameric Nucleoside Diphosphate Kinase of Aquifex Aeolicus Proteins, 80, 2012
|
|
4K5C
| |
7KL2
| |
6VSU
| |
5WM0
| |
8FAH
| Crystal structure of SARS-CoV-2 receptor binding domain in complex with SARS-CoV-2 reactive human antibody CR3022 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CR3022 Fab heavy chain, CR3022 Fab light chain, ... | 著者 | Sankhala, R.S, Jensen, J.L, Joyce, M.G. | 登録日 | 2022-11-26 | 公開日 | 2023-12-13 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (4.22 Å) | 主引用文献 | Antibody targeting of conserved sites of vulnerability on the SARS-CoV-2 spike receptor-binding domain. Structure, 32, 2024
|
|
8GPB
| |
7THZ
| |
8GO8
| Structure of beta-arrestin1 in complex with a phosphopeptide corresponding to the human C5a anaphylatoxin chemotactic receptor 1, C5aR1 | 分子名称: | Beta-arrestin-1, C5a anaphylatoxin chemotactic receptor 1, Fab30 heavy chain, ... | 著者 | Maharana, J, Sarma, P, Yadav, M.K, Banerjee, R, Shukla, A.K. | 登録日 | 2022-08-24 | 公開日 | 2023-05-17 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | 主引用文献 | Structural snapshots uncover a key phosphorylation motif in GPCRs driving beta-arrestin activation. Mol.Cell, 83, 2023
|
|
8GP3
| Structure of beta-arrestin1 in complex with a phosphopeptide corresponding to the human C-X-C chemokine receptor type 4, CXCR4 | 分子名称: | Beta-arrestin-1, C-X-C chemokine receptor type 4, Fab30 Heavy Chain, ... | 著者 | Maharana, J, Sarma, P, Yadav, M.K, Banerjee, R, Shukla, A.K. | 登録日 | 2022-08-25 | 公開日 | 2023-05-17 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Structural snapshots uncover a key phosphorylation motif in GPCRs driving beta-arrestin activation. Mol.Cell, 83, 2023
|
|
6X2J
| Structure of human TRPA1 in complex with agonist GNE551 | 分子名称: | 5-amino-1-[(4-bromo-2-fluorophenyl)methyl]-N-(2,5-dimethoxyphenyl)-1H-1,2,3-triazole-4-carboxamide, Transient receptor potential cation channel subfamily A member 1 | 著者 | Rohou, A, Rouge, L, Chen, H. | 登録日 | 2020-05-20 | 公開日 | 2020-11-18 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel. Neuron, 109, 2021
|
|
7UPE
| Tau Paired Helical Filament from Alzheimer's Disease not incubated with EGCG | 分子名称: | Isoform Tau-F of Microtubule-associated protein tau | 著者 | Seidler, P.M, Murray, K.A, Boyer, D.R, Ge, P, Sawaya, M.R, Eisenberg, D.S. | 登録日 | 2022-04-15 | 公開日 | 2022-09-28 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro. Nat Commun, 13, 2022
|
|
6WUW
| Crystal structure of Human Serum Albumin complex with JMS-053 | 分子名称: | 1,2-ETHANEDIOL, 7-imino-2-phenylthieno[3,2-c]pyridine-4,6(5H,7H)-dione, MYRISTIC ACID, ... | 著者 | Czub, M.P, Cooper, D.R, Shabalin, I.G, Lazo, J.S, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2020-05-05 | 公開日 | 2020-05-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of the Complex of an Iminopyridinedione Protein Tyrosine Phosphatase 4A3 Phosphatase Inhibitor with Human Serum Albumin. Mol.Pharmacol., 98, 2020
|
|
8GSS
| |
8GHO
| GUCY2C-peptide bound to anti-GUCY2C-scFv antibody | 分子名称: | Guanylyl cyclase C peptide, anti-GUCY2C-scFv antibody heavy chain, anti-GUCY2C-scFv antibody light chain | 著者 | Mosyak, L. | 登録日 | 2023-03-10 | 公開日 | 2023-08-30 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Molecular insights into recognition of GUCY2C by T-cell engaging bispecific antibody anti-GUCY2CxCD3. Sci Rep, 13, 2023
|
|