7THZ
Structure of Leucine Rich Repeat Kinase 2's ROC domain interacting with the microtubule facing the plus end
Summary for 7THZ
| Entry DOI | 10.2210/pdb7thz/pdb |
| EMDB information | 25649 25658 25897 25907 |
| Descriptor | Leucine-rich repeat serine/threonine-protein kinase 2, GUANOSINE-5'-DIPHOSPHATE (2 entities in total) |
| Functional Keywords | parkinson's disease, microtubule, kinase, gtpase, cytosolic protein |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 22634.96 |
| Authors | Matyszewski, M.,Leschziner, A.E. (deposition date: 2022-01-12, release date: 2022-12-28, Last modification date: 2024-06-05) |
| Primary citation | Snead, D.M.,Matyszewski, M.,Dickey, A.M.,Lin, Y.X.,Leschziner, A.E.,Reck-Peterson, S.L. Structural basis for Parkinson's disease-linked LRRK2's binding to microtubules. Nat.Struct.Mol.Biol., 29:1196-1207, 2022 Cited by PubMed: 36510024DOI: 10.1038/s41594-022-00863-y PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (5 Å) |
Structure validation
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