8FAH

Crystal structure of SARS-CoV-2 receptor binding domain in complex with SARS-CoV-2 reactive human antibody CR3022

Summary for 8FAH

• Entry DOI: 10.2210/pdb8fah/pdb
• Descriptor: CR3022 Fab heavy chain, CR3022 Fab light chain, Spike protein S1, ... (4 entities in total)
• Functional Keywords: viral protein, immune system, human antibody, sars-cov-2, viral protein-immune system complex, viral protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 71445.70

Authors

Sankhala, R.S.,Jensen, J.L.,Joyce, M.G. (deposition date: 2022-11-26, release date: 2023-12-13, Last modification date: 2024-02-14)

• Primary citation: Sankhala, R.S.,Dussupt, V.,Chen, W.H.,Bai, H.,Martinez, E.J.,Jensen, J.L.,Rees, P.A.,Hajduczki, A.,Chang, W.C.,Choe, M.,Yan, L.,Sterling, S.L.,Swafford, I.,Kuklis, C.,Soman, S.,King, J.,Corbitt, C.,Zemil, M.,Peterson, C.E.,Mendez-Rivera, L.,Townsley, S.M.,Donofrio, G.C.,Lal, K.G.,Tran, U.,Green, E.C.,Smith, C.,de Val, N.,Laing, E.D.,Broder, C.C.,Currier, J.R.,Gromowski, G.D.,Wieczorek, L.,Rolland, M.,Paquin-Proulx, D.,van Dyk, D.,Britton, Z.,Rajan, S.,Loo, Y.M.,McTamney, P.M.,Esser, M.T.,Polonis, V.R.,Michael, N.L.,Krebs, S.J.,Modjarrad, K.,Joyce, M.G.; Antibody targeting of conserved sites of vulnerability on the SARS-CoV-2 spike receptor-binding domain.; Structure, 32:131-, 2024; PubMed: 38157856; DOI: 10.1016/j.str.2023.11.015

Experimental method

X-RAY DIFFRACTION (4.22 Å)