8U3L
 
 | | TRPV1 in nanodisc bound with empty vanilloid binding pocket at 25C | | 分子名称: | 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, SODIUM ION, Transient receptor potential cation channel subfamily V member 1 | | 著者 | Arnold, W.R, Julius, D, Cheng, Y. | | 登録日 | 2023-09-07 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-10-02 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural basis of TRPV1 modulation by endogenous bioactive lipids.
Nat.Struct.Mol.Biol., 31, 2024
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5B31
 | | The crystal structure of the heterotypic H2AZ/H2A nucleosome with H3.1. | | 分子名称: | CHLORIDE ION, DNA (146-MER), Histone H2A type 1-B/E, ... | | 著者 | Horikoshi, N, Taguchi, H, Arimura, Y, Kurumizaka, H. | | 登録日 | 2016-02-08 | | 公開日 | 2016-08-03 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structures of heterotypic nucleosomes containing histones H2A.Z and H2A.
Open Biology, 6, 2016
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5B32
 | | The crystal structure of the heterotypic H2AZ/H2A nucleosome with H3.3. | | 分子名称: | CHLORIDE ION, DNA (146-MER), Histone H2A type 1-B/E, ... | | 著者 | Horikoshi, N, Taguchi, H, Arimura, Y, Kurumizaka, H. | | 登録日 | 2016-02-08 | | 公開日 | 2016-08-03 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Crystal structures of heterotypic nucleosomes containing histones H2A.Z and H2A.
Open Biology, 6, 2016
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5B33
 | | The crystal structure of the H2AZ nucleosome with H3.3. | | 分子名称: | DNA (146-MER), Histone H2A.Z, Histone H2B type 1-J, ... | | 著者 | Horikoshi, N, Taguchi, H, Arimura, Y, Kurumizaka, H. | | 登録日 | 2016-02-08 | | 公開日 | 2016-08-03 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.925 Å) | | 主引用文献 | Crystal structures of heterotypic nucleosomes containing histones H2A.Z and H2A.
Open Biology, 6, 2016
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6SB2
 | | cryo-EM structure of mTORC1 bound to active RagA/C GTPases | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Ras-related GTP-binding protein A, ... | | 著者 | Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L. | | 登録日 | 2019-07-18 | | 公開日 | 2019-10-16 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (6.2 Å) | | 主引用文献 | Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
Science, 366, 2019
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6SB0
 | | cryo-EM structure of mTORC1 bound to PRAS40-fused active RagA/C GTPases | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Proline-rich AKT1 substrate 1, ... | | 著者 | Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L. | | 登録日 | 2019-07-18 | | 公開日 | 2019-10-16 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (5.5 Å) | | 主引用文献 | Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
Science, 366, 2019
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7UXC
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7UXH
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7PE9
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7PEB
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7PE8
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7PEC
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7PEA
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7PE7
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5OAF
 | | Human Rvb1/Rvb2 heterohexamer in INO80 complex | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, RuvB-like 1, RuvB-like 2 | | 著者 | Aramayo, R.J, Bythell-Douglas, R, Ayala, R, Willhoft, O, Wigley, D, Zhang, X. | | 登録日 | 2017-06-21 | | 公開日 | 2017-12-13 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (4.06 Å) | | 主引用文献 | Cryo-EM structures of the human INO80 chromatin-remodeling complex.
Nat. Struct. Mol. Biol., 25, 2018
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8OKX
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8OL1
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4FK5
 | | Structure of the SAGA Ubp8(S144N)/Sgf11/Sus1/Sgf73 DUB module | | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, Protein SUS1, ... | | 著者 | Samara, N.L, Ringel, A.E, Wolberger, C. | | 登録日 | 2012-06-12 | | 公開日 | 2012-07-25 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.032 Å) | | 主引用文献 | A Role for Intersubunit Interactions in Maintaining SAGA Deubiquitinating Module Structure and Activity.
Structure, 20, 2012
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4FIP
 | | Structure of the SAGA Ubp8(S144N)/Sgf11(1-72, Delta-ZnF)/Sus1/Sgf73 DUB module | | 分子名称: | Protein SUS1, SAGA-associated factor 11, SAGA-associated factor 73, ... | | 著者 | Samara, N.L, Ringel, A.E, Wolberger, C. | | 登録日 | 2012-06-10 | | 公開日 | 2012-07-25 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.686 Å) | | 主引用文献 | A Role for Intersubunit Interactions in Maintaining SAGA Deubiquitinating Module Structure and Activity.
Structure, 20, 2012
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3WA9
 | | The nucleosome containing human H2A.Z.1 | | 分子名称: | DNA (146-MER), Histone H2A.Z, Histone H2B type 1-J, ... | | 著者 | Horikoshi, N, Sato, K, Shimada, K, Arimura, Y, Osakabe, A, Tachiwana, H, Iwasaki, W, Kagawa, W, Harata, M, Kimura, H, Kurumizaka, H. | | 登録日 | 2013-04-30 | | 公開日 | 2013-12-18 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (3.07 Å) | | 主引用文献 | Structural polymorphism in the L1 loop regions of human H2A.Z.1 and H2A.Z.2
Acta Crystallogr.,Sect.D, 69, 2013
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4FJC
 | | Structure of the SAGA Ubp8/Sgf11(1-72, Delta-ZnF)/Sus1/Sgf73 DUB module | | 分子名称: | GLYCEROL, Protein SUS1, SAGA-associated factor 11, ... | | 著者 | Samara, N.L, Ringel, A.E, Wolberger, C. | | 登録日 | 2012-06-11 | | 公開日 | 2012-07-25 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.826 Å) | | 主引用文献 | A Role for Intersubunit Interactions in Maintaining SAGA Deubiquitinating Module Structure and Activity.
Structure, 20, 2012
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2EXU
 | | Crystal Structure of Saccharomyces cerevisiae transcription elongation factors Spt4-Spt5NGN domain | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ETHANOL, Transcription initiation protein SPT4/SPT5, ... | | 著者 | Xu, F, Guo, M, Fang, P, Teng, M, Niu, L. | | 登録日 | 2005-11-08 | | 公開日 | 2006-11-08 | | 最終更新日 | 2017-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | | 主引用文献 | Crystal Structure of Saccharomyces cerevisiae transcription elongation factors Spt4-Spt5NGN domain
To be published
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7P4S
 | | BROMODOMAIN OF HUMAN TAF1 (2) WITH naphthyridinone compound | | 分子名称: | 8-[[1-(3-azanylpropyl)piperidin-4-yl]amino]-5-[5-(hydroxymethyl)pyridin-3-yl]-3-methyl-1~{H}-1,7-naphthyridin-2-one, Isoform 2a of Transcription initiation factor TFIID subunit 1 | | 著者 | Chung, C. | | 登録日 | 2021-07-13 | | 公開日 | 2021-10-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | | 主引用文献 | Optimization of Naphthyridones into Selective TATA-Binding Protein Associated Factor 1 (TAF1) Bromodomain Inhibitors.
Acs Med.Chem.Lett., 12, 2021
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7OKQ
 | | Cryo-EM Structure of the DDB1-DCAF1-CUL4A-RBX1 Complex | | 分子名称: | Cullin-4A, DDB1- and CUL4-associated factor 1, DNA damage-binding protein 1, ... | | 著者 | Mohamed, W.I, Schenk, A.D, Kempf, G, Cavadini, S, Thoma, N.H. | | 登録日 | 2021-05-18 | | 公開日 | 2021-10-13 | | 最終更新日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (8.4 Å) | | 主引用文献 | The CRL4 DCAF1 cullin-RING ubiquitin ligase is activated following a switch in oligomerization state.
Embo J., 40, 2021
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8ERA
 | | RMC-5552 in complex with mTORC1 and FKBP12 | | 分子名称: | (3S,5R,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30R,34aS)-5,9,27-trihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-5,6,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-octadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,11,28,29(4H,31H)-tetrone, 1-[6-{[(3M)-4-amino-3-(2-amino-1,3-benzoxazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl}-3,4-dihydroisoquinolin-2(1H)-yl]-3-hydroxypropan-1-one, Peptidyl-prolyl cis-trans isomerase FKBP1A, ... | | 著者 | Tomlinson, A.C.A, Yano, J.K. | | 登録日 | 2022-10-11 | | 公開日 | 2022-12-28 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | | 主引用文献 | Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors.
J.Med.Chem., 66, 2023
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