7P4S

BROMODOMAIN OF HUMAN TAF1 (2) WITH naphthyridinone compound

Summary for 7P4S

Entry DOI	10.2210/pdb7p4s/pdb
Descriptor	Isoform 2a of Transcription initiation factor TFIID subunit 1, 8-[[1-(3-azanylpropyl)piperidin-4-yl]amino]-5-[5-(hydroxymethyl)pyridin-3-yl]-3-methyl-1~{H}-1,7-naphthyridin-2-one (3 entities in total)
Functional Keywords	second bromodomain of taf1, inhibitor-bound, complex, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	16697.83
Authors	Chung, C. (deposition date: 2021-07-13, release date: 2021-10-13, Last modification date: 2024-01-31)
Primary citation	Clegg, M.A.,Theodoulou, N.H.,Bamborough, P.,Chung, C.W.,Craggs, P.D.,Demont, E.H.,Gordon, L.J.,Liwicki, G.M.,Phillipou, A.,Tomkinson, N.C.O.,Prinjha, R.K.,Humphreys, P.G. Optimization of Naphthyridones into Selective TATA-Binding Protein Associated Factor 1 (TAF1) Bromodomain Inhibitors. Acs Med.Chem.Lett., 12:1308-1317, 2021 Cited by PubMed: 34413961 DOI: 10.1021/acsmedchemlett.1c00294 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.17 Å)

Structure validation