7OKQ

Cryo-EM Structure of the DDB1-DCAF1-CUL4A-RBX1 Complex

Summary for 7OKQ

• Entry DOI: 10.2210/pdb7okq/pdb
• EMDB information: 12964
• Descriptor: DNA damage-binding protein 1, DDB1- and CUL4-associated factor 1, Cullin-4A, ... (4 entities in total)
• Functional Keywords: ubiquitin, e3, protein degradation, ligase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 16
• Total formula weight: 1603496.27

Authors

Mohamed, W.I.,Schenk, A.D.,Kempf, G.,Cavadini, S.,Thoma, N.H. (deposition date: 2021-05-18, release date: 2021-10-13, Last modification date: 2021-12-01)

• Primary citation: Mohamed, W.I.,Schenk, A.D.,Kempf, G.,Cavadini, S.,Basters, A.,Potenza, A.,Abdul Rahman, W.,Rabl, J.,Reichermeier, K.,Thoma, N.H.; The CRL4 DCAF1 cullin-RING ubiquitin ligase is activated following a switch in oligomerization state.; Embo J., 40:e108008-e108008, 2021; PubMed: 34595758; DOI: 10.15252/embj.2021108008

Experimental method

ELECTRON MICROSCOPY (8.4 Å)