7OKQ

Cryo-EM Structure of the DDB1-DCAF1-CUL4A-RBX1 Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000781	cellular_component	chromosome, telomeric region
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003684	molecular_function	damaged DNA binding
A	0005515	molecular_function	protein binding
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0006281	biological_process	DNA repair
A	0006289	biological_process	nucleotide-excision repair
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006915	biological_process	apoptotic process
A	0006974	biological_process	DNA damage response
A	0007056	biological_process	spindle assembly involved in female meiosis
A	0010498	biological_process	proteasomal protein catabolic process
A	0016055	biological_process	Wnt signaling pathway
A	0016567	biological_process	protein ubiquitination
A	0019076	biological_process	viral release from host cell
A	0030674	molecular_function	protein-macromolecule adaptor activity
A	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
A	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
A	0032991	cellular_component	protein-containing complex
A	0034644	biological_process	cellular response to UV
A	0035234	biological_process	ectopic germ cell programmed cell death
A	0035861	cellular_component	site of double-strand break
A	0042752	biological_process	regulation of circadian rhythm
A	0043066	biological_process	negative regulation of apoptotic process
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0044725	biological_process	epigenetic programming in the zygotic pronuclei
A	0044877	molecular_function	protein-containing complex binding
A	0045070	biological_process	positive regulation of viral genome replication
A	0045722	biological_process	positive regulation of gluconeogenesis
A	0045732	biological_process	positive regulation of protein catabolic process
A	0046726	biological_process	positive regulation by virus of viral protein levels in host cell
A	0048511	biological_process	rhythmic process
A	0051093	biological_process	negative regulation of developmental process
A	0051702	biological_process	biological process involved in interaction with symbiont
A	0070062	cellular_component	extracellular exosome
A	0070914	biological_process	UV-damage excision repair
A	0071987	molecular_function	WD40-repeat domain binding
A	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
A	0097602	molecular_function	cullin family protein binding
A	0160072	molecular_function	ubiquitin ligase complex scaffold activity
A	1901990	biological_process	regulation of mitotic cell cycle phase transition
A	2000242	biological_process	negative regulation of reproductive process
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0001650	cellular_component	fibrillar center
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0006325	biological_process	chromatin organization
B	0006338	biological_process	chromatin remodeling
B	0008180	cellular_component	COP9 signalosome
B	0016567	biological_process	protein ubiquitination
B	0030183	biological_process	B cell differentiation
B	0030331	molecular_function	nuclear estrogen receptor binding
B	0033151	biological_process	V(D)J recombination
B	0035212	biological_process	cell competition in a multicellular organism
B	0043687	biological_process	post-translational protein modification
B	0045732	biological_process	positive regulation of protein catabolic process
B	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
B	0106310	molecular_function	protein serine kinase activity
B	1990244	molecular_function	histone H2AT120 kinase activity
B	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
C	0000082	biological_process	G1/S transition of mitotic cell cycle
C	0001701	biological_process	in utero embryonic development
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0006281	biological_process	DNA repair
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0006974	biological_process	DNA damage response
C	0007283	biological_process	spermatogenesis
C	0008283	biological_process	cell population proliferation
C	0008284	biological_process	positive regulation of cell population proliferation
C	0016567	biological_process	protein ubiquitination
C	0030097	biological_process	hemopoiesis
C	0030853	biological_process	negative regulation of granulocyte differentiation
C	0031461	cellular_component	cullin-RING ubiquitin ligase complex
C	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0034644	biological_process	cellular response to UV
C	0035019	biological_process	somatic stem cell population maintenance
C	0042110	biological_process	T cell activation
C	0042254	biological_process	ribosome biogenesis
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0045732	biological_process	positive regulation of protein catabolic process
C	0048511	biological_process	rhythmic process
C	0051246	biological_process	regulation of protein metabolic process
C	0061630	molecular_function	ubiquitin protein ligase activity
C	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
C	0097193	biological_process	intrinsic apoptotic signaling pathway
C	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
C	0160072	molecular_function	ubiquitin ligase complex scaffold activity
C	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle
C	2000001	biological_process	regulation of DNA damage checkpoint
C	2000819	biological_process	regulation of nucleotide-excision repair
D	0000165	biological_process	MAPK cascade
D	0000209	biological_process	protein polyubiquitination
D	0004842	molecular_function	ubiquitin-protein transferase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006281	biological_process	DNA repair
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006513	biological_process	protein monoubiquitination
D	0006974	biological_process	DNA damage response
D	0007283	biological_process	spermatogenesis
D	0008270	molecular_function	zinc ion binding
D	0016567	biological_process	protein ubiquitination
D	0016740	molecular_function	transferase activity
D	0019005	cellular_component	SCF ubiquitin ligase complex
D	0019788	molecular_function	NEDD8 transferase activity
D	0030163	biological_process	protein catabolic process
D	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
D	0031461	cellular_component	cullin-RING ubiquitin ligase complex
D	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
D	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
D	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
D	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
D	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
D	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
D	0032480	biological_process	negative regulation of type I interferon production
D	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
D	0034644	biological_process	cellular response to UV
D	0042110	biological_process	T cell activation
D	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0043687	biological_process	post-translational protein modification
D	0045116	biological_process	protein neddylation
D	0045732	biological_process	positive regulation of protein catabolic process
D	0046872	molecular_function	metal ion binding
D	0060090	molecular_function	molecular adaptor activity
D	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
D	0061630	molecular_function	ubiquitin protein ligase activity
D	0061663	molecular_function	NEDD8 ligase activity
D	0062197	biological_process	cellular response to chemical stress
D	0070936	biological_process	protein K48-linked ubiquitination
D	0071230	biological_process	cellular response to amino acid stimulus
D	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
D	0097602	molecular_function	cullin family protein binding
D	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
D	1900076	biological_process	regulation of cellular response to insulin stimulus
D	1902499	biological_process	positive regulation of protein autoubiquitination
D	1902883	biological_process	negative regulation of response to oxidative stress
D	1904263	biological_process	positive regulation of TORC1 signaling
E	0000781	cellular_component	chromosome, telomeric region
E	0003676	molecular_function	nucleic acid binding
E	0003677	molecular_function	DNA binding
E	0003684	molecular_function	damaged DNA binding
E	0005515	molecular_function	protein binding
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005730	cellular_component	nucleolus
E	0005737	cellular_component	cytoplasm
E	0006281	biological_process	DNA repair
E	0006289	biological_process	nucleotide-excision repair
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0006915	biological_process	apoptotic process
E	0006974	biological_process	DNA damage response
E	0007056	biological_process	spindle assembly involved in female meiosis
E	0010498	biological_process	proteasomal protein catabolic process
E	0016055	biological_process	Wnt signaling pathway
E	0016567	biological_process	protein ubiquitination
E	0019076	biological_process	viral release from host cell
E	0030674	molecular_function	protein-macromolecule adaptor activity
E	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
E	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
E	0032991	cellular_component	protein-containing complex
E	0034644	biological_process	cellular response to UV
E	0035234	biological_process	ectopic germ cell programmed cell death
E	0035861	cellular_component	site of double-strand break
E	0042752	biological_process	regulation of circadian rhythm
E	0043066	biological_process	negative regulation of apoptotic process
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0044725	biological_process	epigenetic programming in the zygotic pronuclei
E	0044877	molecular_function	protein-containing complex binding
E	0045070	biological_process	positive regulation of viral genome replication
E	0045722	biological_process	positive regulation of gluconeogenesis
E	0045732	biological_process	positive regulation of protein catabolic process
E	0046726	biological_process	positive regulation by virus of viral protein levels in host cell
E	0048511	biological_process	rhythmic process
E	0051093	biological_process	negative regulation of developmental process
E	0051702	biological_process	biological process involved in interaction with symbiont
E	0070062	cellular_component	extracellular exosome
E	0070914	biological_process	UV-damage excision repair
E	0071987	molecular_function	WD40-repeat domain binding
E	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
E	0097602	molecular_function	cullin family protein binding
E	0160072	molecular_function	ubiquitin ligase complex scaffold activity
E	1901990	biological_process	regulation of mitotic cell cycle phase transition
E	2000242	biological_process	negative regulation of reproductive process
F	0000122	biological_process	negative regulation of transcription by RNA polymerase II
F	0001650	cellular_component	fibrillar center
F	0004674	molecular_function	protein serine/threonine kinase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0006325	biological_process	chromatin organization
F	0006338	biological_process	chromatin remodeling
F	0008180	cellular_component	COP9 signalosome
F	0016567	biological_process	protein ubiquitination
F	0030183	biological_process	B cell differentiation
F	0030331	molecular_function	nuclear estrogen receptor binding
F	0033151	biological_process	V(D)J recombination
F	0035212	biological_process	cell competition in a multicellular organism
F	0043687	biological_process	post-translational protein modification
F	0045732	biological_process	positive regulation of protein catabolic process
F	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
F	0106310	molecular_function	protein serine kinase activity
F	1990244	molecular_function	histone H2AT120 kinase activity
F	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
G	0000082	biological_process	G1/S transition of mitotic cell cycle
G	0001701	biological_process	in utero embryonic development
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0006281	biological_process	DNA repair
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0006974	biological_process	DNA damage response
G	0007283	biological_process	spermatogenesis
G	0008283	biological_process	cell population proliferation
G	0008284	biological_process	positive regulation of cell population proliferation
G	0016567	biological_process	protein ubiquitination
G	0030097	biological_process	hemopoiesis
G	0030853	biological_process	negative regulation of granulocyte differentiation
G	0031461	cellular_component	cullin-RING ubiquitin ligase complex
G	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0034644	biological_process	cellular response to UV
G	0035019	biological_process	somatic stem cell population maintenance
G	0042110	biological_process	T cell activation
G	0042254	biological_process	ribosome biogenesis
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0045732	biological_process	positive regulation of protein catabolic process
G	0048511	biological_process	rhythmic process
G	0051246	biological_process	regulation of protein metabolic process
G	0061630	molecular_function	ubiquitin protein ligase activity
G	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
G	0097193	biological_process	intrinsic apoptotic signaling pathway
G	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
G	0160072	molecular_function	ubiquitin ligase complex scaffold activity
G	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle
G	2000001	biological_process	regulation of DNA damage checkpoint
G	2000819	biological_process	regulation of nucleotide-excision repair
H	0000165	biological_process	MAPK cascade
H	0000209	biological_process	protein polyubiquitination
H	0004842	molecular_function	ubiquitin-protein transferase activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006281	biological_process	DNA repair
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0006513	biological_process	protein monoubiquitination
H	0006974	biological_process	DNA damage response
H	0007283	biological_process	spermatogenesis
H	0008270	molecular_function	zinc ion binding
H	0016567	biological_process	protein ubiquitination
H	0016740	molecular_function	transferase activity
H	0019005	cellular_component	SCF ubiquitin ligase complex
H	0019788	molecular_function	NEDD8 transferase activity
H	0030163	biological_process	protein catabolic process
H	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
H	0031461	cellular_component	cullin-RING ubiquitin ligase complex
H	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
H	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
H	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
H	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
H	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
H	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
H	0031625	molecular_function	ubiquitin protein ligase binding
H	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
H	0032480	biological_process	negative regulation of type I interferon production
H	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
H	0034644	biological_process	cellular response to UV
H	0042110	biological_process	T cell activation
H	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0043687	biological_process	post-translational protein modification
H	0045116	biological_process	protein neddylation
H	0045732	biological_process	positive regulation of protein catabolic process
H	0046872	molecular_function	metal ion binding
H	0060090	molecular_function	molecular adaptor activity
H	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
H	0061630	molecular_function	ubiquitin protein ligase activity
H	0061663	molecular_function	NEDD8 ligase activity
H	0062197	biological_process	cellular response to chemical stress
H	0070936	biological_process	protein K48-linked ubiquitination
H	0071230	biological_process	cellular response to amino acid stimulus
H	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
H	0097602	molecular_function	cullin family protein binding
H	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
H	1900076	biological_process	regulation of cellular response to insulin stimulus
H	1902499	biological_process	positive regulation of protein autoubiquitination
H	1902883	biological_process	negative regulation of response to oxidative stress
H	1904263	biological_process	positive regulation of TORC1 signaling
I	0000781	cellular_component	chromosome, telomeric region
I	0003676	molecular_function	nucleic acid binding
I	0003677	molecular_function	DNA binding
I	0003684	molecular_function	damaged DNA binding
I	0005515	molecular_function	protein binding
I	0005615	cellular_component	extracellular space
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005730	cellular_component	nucleolus
I	0005737	cellular_component	cytoplasm
I	0006281	biological_process	DNA repair
I	0006289	biological_process	nucleotide-excision repair
I	0006511	biological_process	ubiquitin-dependent protein catabolic process
I	0006915	biological_process	apoptotic process
I	0006974	biological_process	DNA damage response
I	0007056	biological_process	spindle assembly involved in female meiosis
I	0010498	biological_process	proteasomal protein catabolic process
I	0016055	biological_process	Wnt signaling pathway
I	0016567	biological_process	protein ubiquitination
I	0019076	biological_process	viral release from host cell
I	0030674	molecular_function	protein-macromolecule adaptor activity
I	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
I	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
I	0032991	cellular_component	protein-containing complex
I	0034644	biological_process	cellular response to UV
I	0035234	biological_process	ectopic germ cell programmed cell death
I	0035861	cellular_component	site of double-strand break
I	0042752	biological_process	regulation of circadian rhythm
I	0043066	biological_process	negative regulation of apoptotic process
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0044725	biological_process	epigenetic programming in the zygotic pronuclei
I	0044877	molecular_function	protein-containing complex binding
I	0045070	biological_process	positive regulation of viral genome replication
I	0045722	biological_process	positive regulation of gluconeogenesis
I	0045732	biological_process	positive regulation of protein catabolic process
I	0046726	biological_process	positive regulation by virus of viral protein levels in host cell
I	0048511	biological_process	rhythmic process
I	0051093	biological_process	negative regulation of developmental process
I	0051702	biological_process	biological process involved in interaction with symbiont
I	0070062	cellular_component	extracellular exosome
I	0070914	biological_process	UV-damage excision repair
I	0071987	molecular_function	WD40-repeat domain binding
I	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
I	0097602	molecular_function	cullin family protein binding
I	0160072	molecular_function	ubiquitin ligase complex scaffold activity
I	1901990	biological_process	regulation of mitotic cell cycle phase transition
I	2000242	biological_process	negative regulation of reproductive process
J	0000122	biological_process	negative regulation of transcription by RNA polymerase II
J	0001650	cellular_component	fibrillar center
J	0004674	molecular_function	protein serine/threonine kinase activity
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0006325	biological_process	chromatin organization
J	0006338	biological_process	chromatin remodeling
J	0008180	cellular_component	COP9 signalosome
J	0016567	biological_process	protein ubiquitination
J	0030183	biological_process	B cell differentiation
J	0030331	molecular_function	nuclear estrogen receptor binding
J	0033151	biological_process	V(D)J recombination
J	0035212	biological_process	cell competition in a multicellular organism
J	0043687	biological_process	post-translational protein modification
J	0045732	biological_process	positive regulation of protein catabolic process
J	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
J	0106310	molecular_function	protein serine kinase activity
J	1990244	molecular_function	histone H2AT120 kinase activity
J	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
K	0000082	biological_process	G1/S transition of mitotic cell cycle
K	0001701	biological_process	in utero embryonic development
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0006281	biological_process	DNA repair
K	0006511	biological_process	ubiquitin-dependent protein catabolic process
K	0006974	biological_process	DNA damage response
K	0007283	biological_process	spermatogenesis
K	0008283	biological_process	cell population proliferation
K	0008284	biological_process	positive regulation of cell population proliferation
K	0016567	biological_process	protein ubiquitination
K	0030097	biological_process	hemopoiesis
K	0030853	biological_process	negative regulation of granulocyte differentiation
K	0031461	cellular_component	cullin-RING ubiquitin ligase complex
K	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
K	0031625	molecular_function	ubiquitin protein ligase binding
K	0034644	biological_process	cellular response to UV
K	0035019	biological_process	somatic stem cell population maintenance
K	0042110	biological_process	T cell activation
K	0042254	biological_process	ribosome biogenesis
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0045732	biological_process	positive regulation of protein catabolic process
K	0048511	biological_process	rhythmic process
K	0051246	biological_process	regulation of protein metabolic process
K	0061630	molecular_function	ubiquitin protein ligase activity
K	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
K	0097193	biological_process	intrinsic apoptotic signaling pathway
K	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
K	0160072	molecular_function	ubiquitin ligase complex scaffold activity
K	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle
K	2000001	biological_process	regulation of DNA damage checkpoint
K	2000819	biological_process	regulation of nucleotide-excision repair
L	0000165	biological_process	MAPK cascade
L	0000209	biological_process	protein polyubiquitination
L	0004842	molecular_function	ubiquitin-protein transferase activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006281	biological_process	DNA repair
L	0006511	biological_process	ubiquitin-dependent protein catabolic process
L	0006513	biological_process	protein monoubiquitination
L	0006974	biological_process	DNA damage response
L	0007283	biological_process	spermatogenesis
L	0008270	molecular_function	zinc ion binding
L	0016567	biological_process	protein ubiquitination
L	0016740	molecular_function	transferase activity
L	0019005	cellular_component	SCF ubiquitin ligase complex
L	0019788	molecular_function	NEDD8 transferase activity
L	0030163	biological_process	protein catabolic process
L	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
L	0031461	cellular_component	cullin-RING ubiquitin ligase complex
L	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
L	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
L	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
L	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
L	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
L	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
L	0031625	molecular_function	ubiquitin protein ligase binding
L	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
L	0032480	biological_process	negative regulation of type I interferon production
L	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
L	0034644	biological_process	cellular response to UV
L	0042110	biological_process	T cell activation
L	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0043687	biological_process	post-translational protein modification
L	0045116	biological_process	protein neddylation
L	0045732	biological_process	positive regulation of protein catabolic process
L	0046872	molecular_function	metal ion binding
L	0060090	molecular_function	molecular adaptor activity
L	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
L	0061630	molecular_function	ubiquitin protein ligase activity
L	0061663	molecular_function	NEDD8 ligase activity
L	0062197	biological_process	cellular response to chemical stress
L	0070936	biological_process	protein K48-linked ubiquitination
L	0071230	biological_process	cellular response to amino acid stimulus
L	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
L	0097602	molecular_function	cullin family protein binding
L	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
L	1900076	biological_process	regulation of cellular response to insulin stimulus
L	1902499	biological_process	positive regulation of protein autoubiquitination
L	1902883	biological_process	negative regulation of response to oxidative stress
L	1904263	biological_process	positive regulation of TORC1 signaling
M	0000781	cellular_component	chromosome, telomeric region
M	0003676	molecular_function	nucleic acid binding
M	0003677	molecular_function	DNA binding
M	0003684	molecular_function	damaged DNA binding
M	0005515	molecular_function	protein binding
M	0005615	cellular_component	extracellular space
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005730	cellular_component	nucleolus
M	0005737	cellular_component	cytoplasm
M	0006281	biological_process	DNA repair
M	0006289	biological_process	nucleotide-excision repair
M	0006511	biological_process	ubiquitin-dependent protein catabolic process
M	0006915	biological_process	apoptotic process
M	0006974	biological_process	DNA damage response
M	0007056	biological_process	spindle assembly involved in female meiosis
M	0010498	biological_process	proteasomal protein catabolic process
M	0016055	biological_process	Wnt signaling pathway
M	0016567	biological_process	protein ubiquitination
M	0019076	biological_process	viral release from host cell
M	0030674	molecular_function	protein-macromolecule adaptor activity
M	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
M	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
M	0032991	cellular_component	protein-containing complex
M	0034644	biological_process	cellular response to UV
M	0035234	biological_process	ectopic germ cell programmed cell death
M	0035861	cellular_component	site of double-strand break
M	0042752	biological_process	regulation of circadian rhythm
M	0043066	biological_process	negative regulation of apoptotic process
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
M	0044725	biological_process	epigenetic programming in the zygotic pronuclei
M	0044877	molecular_function	protein-containing complex binding
M	0045070	biological_process	positive regulation of viral genome replication
M	0045722	biological_process	positive regulation of gluconeogenesis
M	0045732	biological_process	positive regulation of protein catabolic process
M	0046726	biological_process	positive regulation by virus of viral protein levels in host cell
M	0048511	biological_process	rhythmic process
M	0051093	biological_process	negative regulation of developmental process
M	0051702	biological_process	biological process involved in interaction with symbiont
M	0070062	cellular_component	extracellular exosome
M	0070914	biological_process	UV-damage excision repair
M	0071987	molecular_function	WD40-repeat domain binding
M	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
M	0097602	molecular_function	cullin family protein binding
M	0160072	molecular_function	ubiquitin ligase complex scaffold activity
M	1901990	biological_process	regulation of mitotic cell cycle phase transition
M	2000242	biological_process	negative regulation of reproductive process
N	0000122	biological_process	negative regulation of transcription by RNA polymerase II
N	0001650	cellular_component	fibrillar center
N	0004674	molecular_function	protein serine/threonine kinase activity
N	0005515	molecular_function	protein binding
N	0005524	molecular_function	ATP binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005737	cellular_component	cytoplasm
N	0006325	biological_process	chromatin organization
N	0006338	biological_process	chromatin remodeling
N	0008180	cellular_component	COP9 signalosome
N	0016567	biological_process	protein ubiquitination
N	0030183	biological_process	B cell differentiation
N	0030331	molecular_function	nuclear estrogen receptor binding
N	0033151	biological_process	V(D)J recombination
N	0035212	biological_process	cell competition in a multicellular organism
N	0043687	biological_process	post-translational protein modification
N	0045732	biological_process	positive regulation of protein catabolic process
N	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
N	0106310	molecular_function	protein serine kinase activity
N	1990244	molecular_function	histone H2AT120 kinase activity
N	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
O	0000082	biological_process	G1/S transition of mitotic cell cycle
O	0001701	biological_process	in utero embryonic development
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0006281	biological_process	DNA repair
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
O	0006974	biological_process	DNA damage response
O	0007283	biological_process	spermatogenesis
O	0008283	biological_process	cell population proliferation
O	0008284	biological_process	positive regulation of cell population proliferation
O	0016567	biological_process	protein ubiquitination
O	0030097	biological_process	hemopoiesis
O	0030853	biological_process	negative regulation of granulocyte differentiation
O	0031461	cellular_component	cullin-RING ubiquitin ligase complex
O	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
O	0031625	molecular_function	ubiquitin protein ligase binding
O	0034644	biological_process	cellular response to UV
O	0035019	biological_process	somatic stem cell population maintenance
O	0042110	biological_process	T cell activation
O	0042254	biological_process	ribosome biogenesis
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0045732	biological_process	positive regulation of protein catabolic process
O	0048511	biological_process	rhythmic process
O	0051246	biological_process	regulation of protein metabolic process
O	0061630	molecular_function	ubiquitin protein ligase activity
O	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
O	0097193	biological_process	intrinsic apoptotic signaling pathway
O	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
O	0160072	molecular_function	ubiquitin ligase complex scaffold activity
O	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle
O	2000001	biological_process	regulation of DNA damage checkpoint
O	2000819	biological_process	regulation of nucleotide-excision repair
P	0000165	biological_process	MAPK cascade
P	0000209	biological_process	protein polyubiquitination
P	0004842	molecular_function	ubiquitin-protein transferase activity
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006281	biological_process	DNA repair
P	0006511	biological_process	ubiquitin-dependent protein catabolic process
P	0006513	biological_process	protein monoubiquitination
P	0006974	biological_process	DNA damage response
P	0007283	biological_process	spermatogenesis
P	0008270	molecular_function	zinc ion binding
P	0016567	biological_process	protein ubiquitination
P	0016740	molecular_function	transferase activity
P	0019005	cellular_component	SCF ubiquitin ligase complex
P	0019788	molecular_function	NEDD8 transferase activity
P	0030163	biological_process	protein catabolic process
P	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
P	0031461	cellular_component	cullin-RING ubiquitin ligase complex
P	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
P	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
P	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
P	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
P	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
P	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
P	0031625	molecular_function	ubiquitin protein ligase binding
P	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
P	0032480	biological_process	negative regulation of type I interferon production
P	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
P	0034644	biological_process	cellular response to UV
P	0042110	biological_process	T cell activation
P	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0043687	biological_process	post-translational protein modification
P	0045116	biological_process	protein neddylation
P	0045732	biological_process	positive regulation of protein catabolic process
P	0046872	molecular_function	metal ion binding
P	0060090	molecular_function	molecular adaptor activity
P	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
P	0061630	molecular_function	ubiquitin protein ligase activity
P	0061663	molecular_function	NEDD8 ligase activity
P	0062197	biological_process	cellular response to chemical stress
P	0070936	biological_process	protein K48-linked ubiquitination
P	0071230	biological_process	cellular response to amino acid stimulus
P	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
P	0097602	molecular_function	cullin family protein binding
P	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
P	1900076	biological_process	regulation of cellular response to insulin stimulus
P	1902499	biological_process	positive regulation of protein autoubiquitination
P	1902883	biological_process	negative regulation of response to oxidative stress
P	1904263	biological_process	positive regulation of TORC1 signaling

Functional Information from PROSITE/UniProt

site_id	PS01256
Number of Residues	28
Details	CULLIN_1 Cullin family signature. LKkrIesLIDRdYMeRdkdnpnqYhYvA

Chain	Residue	Details
C	LEU732-ALA759

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	180
Details	ZN_FING: RING-type => ECO:0000255|PROSITE-ProRule:PRU00175

Chain	Residue	Details
D	CYS53-ASN98
H	CYS53-ASN98
L	CYS53-ASN98
P	CYS53-ASN98
K	LYS705
O	LYS705

---

site_id	SWS_FT_FI2
Number of Residues	44
Details	BINDING: BINDING => ECO:0000269|PubMed:11961546, ECO:0007744|PDB:1LDJ, ECO:0007744|PDB:1LDK, ECO:0007744|PDB:1U6G, ECO:0007744|PDB:2HYE, ECO:0007744|PDB:3DPL, ECO:0007744|PDB:3DQV, ECO:0007744|PDB:3RTR, ECO:0007744|PDB:4F52, ECO:0007744|PDB:4P5O

Chain	Residue	Details
D	CYS42
D	CYS94
D	ASP97
H	CYS42
H	CYS45
H	CYS53
H	CYS56
H	CYS68
H	CYS75
H	HIS77
H	HIS80
D	CYS45
H	HIS82
H	CYS94
H	ASP97
L	CYS42
L	CYS45
L	CYS53
L	CYS56
L	CYS68
L	CYS75
L	HIS77
D	CYS53
L	HIS80
L	HIS82
L	CYS94
L	ASP97
P	CYS42
P	CYS45
P	CYS53
P	CYS56
P	CYS68
P	CYS75
D	CYS56
P	HIS77
P	HIS80
P	HIS82
P	CYS94
P	ASP97
D	CYS68
D	CYS75
D	HIS77
D	HIS80
D	HIS82

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:11961546, ECO:0007744|PDB:1LDJ, ECO:0007744|PDB:1LDK, ECO:0007744|PDB:1U6G, ECO:0007744|PDB:2HYE, ECO:0007744|PDB:3DQV, ECO:0007744|PDB:3RTR, ECO:0007744|PDB:4F52, ECO:0007744|PDB:4P5O

Chain	Residue	Details
D	CYS83
H	CYS83
L	CYS83
P	CYS83

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:20068231

Chain	Residue	Details
D	MET-7
H	MET-7
L	MET-7
P	MET-7
I	LYS1121
M	LYS1121

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: N-acetylalanine; in E3 ubiquitin-protein ligase RBX1, N-terminally processed => ECO:0000269|Ref.8, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378

Chain	Residue	Details
D	HIS-5
H	HIS-5
L	HIS-5
P	HIS-5

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
D	GLY9
H	GLY9
L	GLY9
P	GLY9

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	SER979
F	SER979
J	SER979
N	SER979

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:24275569

Chain	Residue	Details
B	SER1000
F	SER1000
J	SER1000
N	SER1000

---