7OKQ

Cryo-EM Structure of the DDB1-DCAF1-CUL4A-RBX1 Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000781	cellular_component	chromosome, telomeric region
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003684	molecular_function	damaged DNA binding
A	0005515	molecular_function	protein binding
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0006281	biological_process	DNA repair
A	0006289	biological_process	nucleotide-excision repair
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0006915	biological_process	apoptotic process
A	0006974	biological_process	DNA damage response
A	0007056	biological_process	spindle assembly involved in female meiosis
A	0010498	biological_process	proteasomal protein catabolic process
A	0016055	biological_process	Wnt signaling pathway
A	0016567	biological_process	protein ubiquitination
A	0019076	biological_process	viral release from host cell
A	0030674	molecular_function	protein-macromolecule adaptor activity
A	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
A	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
A	0032991	cellular_component	protein-containing complex
A	0034644	biological_process	cellular response to UV
A	0035234	biological_process	ectopic germ cell programmed cell death
A	0035861	cellular_component	site of double-strand break
A	0042752	biological_process	regulation of circadian rhythm
A	0043066	biological_process	negative regulation of apoptotic process
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0044725	biological_process	epigenetic programming in the zygotic pronuclei
A	0044877	molecular_function	protein-containing complex binding
A	0045070	biological_process	positive regulation of viral genome replication
A	0045722	biological_process	positive regulation of gluconeogenesis
A	0045732	biological_process	positive regulation of protein catabolic process
A	0046726	biological_process	positive regulation by virus of viral protein levels in host cell
A	0048511	biological_process	rhythmic process
A	0051093	biological_process	negative regulation of developmental process
A	0051702	biological_process	biological process involved in interaction with symbiont
A	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A	0060337	biological_process	type I interferon-mediated signaling pathway
A	0070062	cellular_component	extracellular exosome
A	0070914	biological_process	UV-damage excision repair
A	0071987	molecular_function	WD40-repeat domain binding
A	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
A	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
A	0097602	molecular_function	cullin family protein binding
A	0160072	molecular_function	ubiquitin ligase complex scaffold activity
A	1901990	biological_process	regulation of mitotic cell cycle phase transition
A	2000242	biological_process	negative regulation of reproductive process
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000166	molecular_function	nucleotide binding
B	0001650	cellular_component	fibrillar center
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005813	cellular_component	centrosome
B	0005856	cellular_component	cytoskeleton
B	0006325	biological_process	chromatin organization
B	0006338	biological_process	chromatin remodeling
B	0008180	cellular_component	COP9 signalosome
B	0016301	molecular_function	kinase activity
B	0016567	biological_process	protein ubiquitination
B	0016740	molecular_function	transferase activity
B	0030183	biological_process	B cell differentiation
B	0030331	molecular_function	nuclear estrogen receptor binding
B	0033151	biological_process	V(D)J recombination
B	0035212	biological_process	cell competition in a multicellular organism
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0043687	biological_process	post-translational protein modification
B	0045732	biological_process	positive regulation of protein catabolic process
B	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
B	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
B	0106310	molecular_function	protein serine kinase activity
B	1990244	molecular_function	histone H2AT120 kinase activity
B	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
C	0000082	biological_process	G1/S transition of mitotic cell cycle
C	0001701	biological_process	in utero embryonic development
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0006281	biological_process	DNA repair
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0006974	biological_process	DNA damage response
C	0007283	biological_process	spermatogenesis
C	0008283	biological_process	cell population proliferation
C	0008284	biological_process	positive regulation of cell population proliferation
C	0016567	biological_process	protein ubiquitination
C	0030097	biological_process	hemopoiesis
C	0030853	biological_process	negative regulation of granulocyte differentiation
C	0031461	cellular_component	cullin-RING ubiquitin ligase complex
C	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0032502	biological_process	developmental process
C	0034644	biological_process	cellular response to UV
C	0035019	biological_process	somatic stem cell population maintenance
C	0035279	biological_process	miRNA-mediated gene silencing by mRNA destabilization
C	0042110	biological_process	T cell activation
C	0042254	biological_process	ribosome biogenesis
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0045732	biological_process	positive regulation of protein catabolic process
C	0048511	biological_process	rhythmic process
C	0051246	biological_process	regulation of protein metabolic process
C	0060337	biological_process	type I interferon-mediated signaling pathway
C	0061630	molecular_function	ubiquitin protein ligase activity
C	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
C	0097193	biological_process	intrinsic apoptotic signaling pathway
C	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
C	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
C	0160072	molecular_function	ubiquitin ligase complex scaffold activity
C	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle
C	2000001	biological_process	regulation of DNA damage checkpoint
C	2000819	biological_process	regulation of nucleotide-excision repair
D	0000045	biological_process	autophagosome assembly
D	0000082	biological_process	G1/S transition of mitotic cell cycle
D	0000165	biological_process	MAPK cascade
D	0000209	biological_process	protein polyubiquitination
D	0000423	biological_process	mitophagy
D	0001837	biological_process	epithelial to mesenchymal transition
D	0004842	molecular_function	ubiquitin-protein transferase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006281	biological_process	DNA repair
D	0006283	biological_process	transcription-coupled nucleotide-excision repair
D	0006366	biological_process	transcription by RNA polymerase II
D	0006368	biological_process	transcription elongation by RNA polymerase II
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0006513	biological_process	protein monoubiquitination
D	0006915	biological_process	apoptotic process
D	0006974	biological_process	DNA damage response
D	0006979	biological_process	response to oxidative stress
D	0007040	biological_process	lysosome organization
D	0007283	biological_process	spermatogenesis
D	0007346	biological_process	regulation of mitotic cell cycle
D	0008270	molecular_function	zinc ion binding
D	0008286	biological_process	insulin receptor signaling pathway
D	0010507	biological_process	negative regulation of autophagy
D	0010508	biological_process	positive regulation of autophagy
D	0016567	biological_process	protein ubiquitination
D	0016740	molecular_function	transferase activity
D	0019005	cellular_component	SCF ubiquitin ligase complex
D	0019221	biological_process	cytokine-mediated signaling pathway
D	0019788	molecular_function	NEDD8 transferase activity
D	0030163	biological_process	protein catabolic process
D	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
D	0030891	cellular_component	VCB complex
D	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
D	0031461	cellular_component	cullin-RING ubiquitin ligase complex
D	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
D	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
D	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
D	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
D	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
D	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0031669	biological_process	cellular response to nutrient levels
D	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
D	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
D	0032480	biological_process	negative regulation of type I interferon production
D	0032481	biological_process	positive regulation of type I interferon production
D	0032869	biological_process	cellular response to insulin stimulus
D	0034198	biological_process	cellular response to amino acid starvation
D	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
D	0034599	biological_process	cellular response to oxidative stress
D	0034644	biological_process	cellular response to UV
D	0035279	biological_process	miRNA-mediated gene silencing by mRNA destabilization
D	0038066	biological_process	p38MAPK cascade
D	0038202	biological_process	TORC1 signaling
D	0042110	biological_process	T cell activation
D	0042770	biological_process	signal transduction in response to DNA damage
D	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
D	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0043687	biological_process	post-translational protein modification
D	0044877	molecular_function	protein-containing complex binding
D	0045116	biological_process	protein neddylation
D	0045727	biological_process	positive regulation of translation
D	0045732	biological_process	positive regulation of protein catabolic process
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0046627	biological_process	negative regulation of insulin receptor signaling pathway
D	0046872	molecular_function	metal ion binding
D	0060090	molecular_function	molecular adaptor activity
D	0060337	biological_process	type I interferon-mediated signaling pathway
D	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
D	0061630	molecular_function	ubiquitin protein ligase activity
D	0061663	molecular_function	NEDD8 ligase activity
D	0062197	biological_process	cellular response to chemical stress
D	0070294	biological_process	renal sodium ion absorption
D	0070936	biological_process	protein K48-linked ubiquitination
D	0071230	biological_process	cellular response to amino acid stimulus
D	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
D	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
D	0090734	cellular_component	site of DNA damage
D	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
D	0097602	molecular_function	cullin family protein binding
D	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
D	0160240	biological_process	RNA polymerase II transcription initiation surveillance
D	1900076	biological_process	regulation of cellular response to insulin stimulus
D	1901525	biological_process	negative regulation of mitophagy
D	1901797	biological_process	negative regulation of signal transduction by p53 class mediator
D	1902499	biological_process	positive regulation of protein autoubiquitination
D	1902883	biological_process	negative regulation of response to oxidative stress
D	1904037	biological_process	positive regulation of epithelial cell apoptotic process
D	1904262	biological_process	negative regulation of TORC1 signaling
D	1904263	biological_process	positive regulation of TORC1 signaling
D	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process
E	0000781	cellular_component	chromosome, telomeric region
E	0003676	molecular_function	nucleic acid binding
E	0003677	molecular_function	DNA binding
E	0003684	molecular_function	damaged DNA binding
E	0005515	molecular_function	protein binding
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005730	cellular_component	nucleolus
E	0005737	cellular_component	cytoplasm
E	0006281	biological_process	DNA repair
E	0006289	biological_process	nucleotide-excision repair
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0006915	biological_process	apoptotic process
E	0006974	biological_process	DNA damage response
E	0007056	biological_process	spindle assembly involved in female meiosis
E	0010498	biological_process	proteasomal protein catabolic process
E	0016055	biological_process	Wnt signaling pathway
E	0016567	biological_process	protein ubiquitination
E	0019076	biological_process	viral release from host cell
E	0030674	molecular_function	protein-macromolecule adaptor activity
E	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
E	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
E	0032991	cellular_component	protein-containing complex
E	0034644	biological_process	cellular response to UV
E	0035234	biological_process	ectopic germ cell programmed cell death
E	0035861	cellular_component	site of double-strand break
E	0042752	biological_process	regulation of circadian rhythm
E	0043066	biological_process	negative regulation of apoptotic process
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0044725	biological_process	epigenetic programming in the zygotic pronuclei
E	0044877	molecular_function	protein-containing complex binding
E	0045070	biological_process	positive regulation of viral genome replication
E	0045722	biological_process	positive regulation of gluconeogenesis
E	0045732	biological_process	positive regulation of protein catabolic process
E	0046726	biological_process	positive regulation by virus of viral protein levels in host cell
E	0048511	biological_process	rhythmic process
E	0051093	biological_process	negative regulation of developmental process
E	0051702	biological_process	biological process involved in interaction with symbiont
E	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
E	0060337	biological_process	type I interferon-mediated signaling pathway
E	0070062	cellular_component	extracellular exosome
E	0070914	biological_process	UV-damage excision repair
E	0071987	molecular_function	WD40-repeat domain binding
E	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
E	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
E	0097602	molecular_function	cullin family protein binding
E	0160072	molecular_function	ubiquitin ligase complex scaffold activity
E	1901990	biological_process	regulation of mitotic cell cycle phase transition
E	2000242	biological_process	negative regulation of reproductive process
F	0000122	biological_process	negative regulation of transcription by RNA polymerase II
F	0000166	molecular_function	nucleotide binding
F	0001650	cellular_component	fibrillar center
F	0004674	molecular_function	protein serine/threonine kinase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005813	cellular_component	centrosome
F	0005856	cellular_component	cytoskeleton
F	0006325	biological_process	chromatin organization
F	0006338	biological_process	chromatin remodeling
F	0008180	cellular_component	COP9 signalosome
F	0016301	molecular_function	kinase activity
F	0016567	biological_process	protein ubiquitination
F	0016740	molecular_function	transferase activity
F	0030183	biological_process	B cell differentiation
F	0030331	molecular_function	nuclear estrogen receptor binding
F	0033151	biological_process	V(D)J recombination
F	0035212	biological_process	cell competition in a multicellular organism
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0043687	biological_process	post-translational protein modification
F	0045732	biological_process	positive regulation of protein catabolic process
F	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
F	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
F	0106310	molecular_function	protein serine kinase activity
F	1990244	molecular_function	histone H2AT120 kinase activity
F	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
G	0000082	biological_process	G1/S transition of mitotic cell cycle
G	0001701	biological_process	in utero embryonic development
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0006281	biological_process	DNA repair
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0006974	biological_process	DNA damage response
G	0007283	biological_process	spermatogenesis
G	0008283	biological_process	cell population proliferation
G	0008284	biological_process	positive regulation of cell population proliferation
G	0016567	biological_process	protein ubiquitination
G	0030097	biological_process	hemopoiesis
G	0030853	biological_process	negative regulation of granulocyte differentiation
G	0031461	cellular_component	cullin-RING ubiquitin ligase complex
G	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0032502	biological_process	developmental process
G	0034644	biological_process	cellular response to UV
G	0035019	biological_process	somatic stem cell population maintenance
G	0035279	biological_process	miRNA-mediated gene silencing by mRNA destabilization
G	0042110	biological_process	T cell activation
G	0042254	biological_process	ribosome biogenesis
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0045732	biological_process	positive regulation of protein catabolic process
G	0048511	biological_process	rhythmic process
G	0051246	biological_process	regulation of protein metabolic process
G	0060337	biological_process	type I interferon-mediated signaling pathway
G	0061630	molecular_function	ubiquitin protein ligase activity
G	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
G	0097193	biological_process	intrinsic apoptotic signaling pathway
G	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
G	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
G	0160072	molecular_function	ubiquitin ligase complex scaffold activity
G	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle
G	2000001	biological_process	regulation of DNA damage checkpoint
G	2000819	biological_process	regulation of nucleotide-excision repair
H	0000045	biological_process	autophagosome assembly
H	0000082	biological_process	G1/S transition of mitotic cell cycle
H	0000165	biological_process	MAPK cascade
H	0000209	biological_process	protein polyubiquitination
H	0000423	biological_process	mitophagy
H	0001837	biological_process	epithelial to mesenchymal transition
H	0004842	molecular_function	ubiquitin-protein transferase activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006281	biological_process	DNA repair
H	0006283	biological_process	transcription-coupled nucleotide-excision repair
H	0006366	biological_process	transcription by RNA polymerase II
H	0006368	biological_process	transcription elongation by RNA polymerase II
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0006513	biological_process	protein monoubiquitination
H	0006915	biological_process	apoptotic process
H	0006974	biological_process	DNA damage response
H	0006979	biological_process	response to oxidative stress
H	0007040	biological_process	lysosome organization
H	0007283	biological_process	spermatogenesis
H	0007346	biological_process	regulation of mitotic cell cycle
H	0008270	molecular_function	zinc ion binding
H	0008286	biological_process	insulin receptor signaling pathway
H	0010507	biological_process	negative regulation of autophagy
H	0010508	biological_process	positive regulation of autophagy
H	0016567	biological_process	protein ubiquitination
H	0016740	molecular_function	transferase activity
H	0019005	cellular_component	SCF ubiquitin ligase complex
H	0019221	biological_process	cytokine-mediated signaling pathway
H	0019788	molecular_function	NEDD8 transferase activity
H	0030163	biological_process	protein catabolic process
H	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
H	0030891	cellular_component	VCB complex
H	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
H	0031461	cellular_component	cullin-RING ubiquitin ligase complex
H	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
H	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
H	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
H	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
H	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
H	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
H	0031625	molecular_function	ubiquitin protein ligase binding
H	0031669	biological_process	cellular response to nutrient levels
H	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
H	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
H	0032480	biological_process	negative regulation of type I interferon production
H	0032481	biological_process	positive regulation of type I interferon production
H	0032869	biological_process	cellular response to insulin stimulus
H	0034198	biological_process	cellular response to amino acid starvation
H	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
H	0034599	biological_process	cellular response to oxidative stress
H	0034644	biological_process	cellular response to UV
H	0035279	biological_process	miRNA-mediated gene silencing by mRNA destabilization
H	0038066	biological_process	p38MAPK cascade
H	0038202	biological_process	TORC1 signaling
H	0042110	biological_process	T cell activation
H	0042770	biological_process	signal transduction in response to DNA damage
H	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
H	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0043687	biological_process	post-translational protein modification
H	0044877	molecular_function	protein-containing complex binding
H	0045116	biological_process	protein neddylation
H	0045727	biological_process	positive regulation of translation
H	0045732	biological_process	positive regulation of protein catabolic process
H	0045944	biological_process	positive regulation of transcription by RNA polymerase II
H	0046627	biological_process	negative regulation of insulin receptor signaling pathway
H	0046872	molecular_function	metal ion binding
H	0060090	molecular_function	molecular adaptor activity
H	0060337	biological_process	type I interferon-mediated signaling pathway
H	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
H	0061630	molecular_function	ubiquitin protein ligase activity
H	0061663	molecular_function	NEDD8 ligase activity
H	0062197	biological_process	cellular response to chemical stress
H	0070294	biological_process	renal sodium ion absorption
H	0070936	biological_process	protein K48-linked ubiquitination
H	0071230	biological_process	cellular response to amino acid stimulus
H	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
H	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
H	0090734	cellular_component	site of DNA damage
H	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
H	0097602	molecular_function	cullin family protein binding
H	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
H	0160240	biological_process	RNA polymerase II transcription initiation surveillance
H	1900076	biological_process	regulation of cellular response to insulin stimulus
H	1901525	biological_process	negative regulation of mitophagy
H	1901797	biological_process	negative regulation of signal transduction by p53 class mediator
H	1902499	biological_process	positive regulation of protein autoubiquitination
H	1902883	biological_process	negative regulation of response to oxidative stress
H	1904037	biological_process	positive regulation of epithelial cell apoptotic process
H	1904262	biological_process	negative regulation of TORC1 signaling
H	1904263	biological_process	positive regulation of TORC1 signaling
H	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process
I	0000781	cellular_component	chromosome, telomeric region
I	0003676	molecular_function	nucleic acid binding
I	0003677	molecular_function	DNA binding
I	0003684	molecular_function	damaged DNA binding
I	0005515	molecular_function	protein binding
I	0005615	cellular_component	extracellular space
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005730	cellular_component	nucleolus
I	0005737	cellular_component	cytoplasm
I	0006281	biological_process	DNA repair
I	0006289	biological_process	nucleotide-excision repair
I	0006511	biological_process	ubiquitin-dependent protein catabolic process
I	0006915	biological_process	apoptotic process
I	0006974	biological_process	DNA damage response
I	0007056	biological_process	spindle assembly involved in female meiosis
I	0010498	biological_process	proteasomal protein catabolic process
I	0016055	biological_process	Wnt signaling pathway
I	0016567	biological_process	protein ubiquitination
I	0019076	biological_process	viral release from host cell
I	0030674	molecular_function	protein-macromolecule adaptor activity
I	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
I	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
I	0032991	cellular_component	protein-containing complex
I	0034644	biological_process	cellular response to UV
I	0035234	biological_process	ectopic germ cell programmed cell death
I	0035861	cellular_component	site of double-strand break
I	0042752	biological_process	regulation of circadian rhythm
I	0043066	biological_process	negative regulation of apoptotic process
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0044725	biological_process	epigenetic programming in the zygotic pronuclei
I	0044877	molecular_function	protein-containing complex binding
I	0045070	biological_process	positive regulation of viral genome replication
I	0045722	biological_process	positive regulation of gluconeogenesis
I	0045732	biological_process	positive regulation of protein catabolic process
I	0046726	biological_process	positive regulation by virus of viral protein levels in host cell
I	0048511	biological_process	rhythmic process
I	0051093	biological_process	negative regulation of developmental process
I	0051702	biological_process	biological process involved in interaction with symbiont
I	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
I	0060337	biological_process	type I interferon-mediated signaling pathway
I	0070062	cellular_component	extracellular exosome
I	0070914	biological_process	UV-damage excision repair
I	0071987	molecular_function	WD40-repeat domain binding
I	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
I	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
I	0097602	molecular_function	cullin family protein binding
I	0160072	molecular_function	ubiquitin ligase complex scaffold activity
I	1901990	biological_process	regulation of mitotic cell cycle phase transition
I	2000242	biological_process	negative regulation of reproductive process
J	0000122	biological_process	negative regulation of transcription by RNA polymerase II
J	0000166	molecular_function	nucleotide binding
J	0001650	cellular_component	fibrillar center
J	0004674	molecular_function	protein serine/threonine kinase activity
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005813	cellular_component	centrosome
J	0005856	cellular_component	cytoskeleton
J	0006325	biological_process	chromatin organization
J	0006338	biological_process	chromatin remodeling
J	0008180	cellular_component	COP9 signalosome
J	0016301	molecular_function	kinase activity
J	0016567	biological_process	protein ubiquitination
J	0016740	molecular_function	transferase activity
J	0030183	biological_process	B cell differentiation
J	0030331	molecular_function	nuclear estrogen receptor binding
J	0033151	biological_process	V(D)J recombination
J	0035212	biological_process	cell competition in a multicellular organism
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0043687	biological_process	post-translational protein modification
J	0045732	biological_process	positive regulation of protein catabolic process
J	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
J	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
J	0106310	molecular_function	protein serine kinase activity
J	1990244	molecular_function	histone H2AT120 kinase activity
J	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
K	0000082	biological_process	G1/S transition of mitotic cell cycle
K	0001701	biological_process	in utero embryonic development
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0006281	biological_process	DNA repair
K	0006511	biological_process	ubiquitin-dependent protein catabolic process
K	0006974	biological_process	DNA damage response
K	0007283	biological_process	spermatogenesis
K	0008283	biological_process	cell population proliferation
K	0008284	biological_process	positive regulation of cell population proliferation
K	0016567	biological_process	protein ubiquitination
K	0030097	biological_process	hemopoiesis
K	0030853	biological_process	negative regulation of granulocyte differentiation
K	0031461	cellular_component	cullin-RING ubiquitin ligase complex
K	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
K	0031625	molecular_function	ubiquitin protein ligase binding
K	0032502	biological_process	developmental process
K	0034644	biological_process	cellular response to UV
K	0035019	biological_process	somatic stem cell population maintenance
K	0035279	biological_process	miRNA-mediated gene silencing by mRNA destabilization
K	0042110	biological_process	T cell activation
K	0042254	biological_process	ribosome biogenesis
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0045732	biological_process	positive regulation of protein catabolic process
K	0048511	biological_process	rhythmic process
K	0051246	biological_process	regulation of protein metabolic process
K	0060337	biological_process	type I interferon-mediated signaling pathway
K	0061630	molecular_function	ubiquitin protein ligase activity
K	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
K	0097193	biological_process	intrinsic apoptotic signaling pathway
K	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
K	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
K	0160072	molecular_function	ubiquitin ligase complex scaffold activity
K	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle
K	2000001	biological_process	regulation of DNA damage checkpoint
K	2000819	biological_process	regulation of nucleotide-excision repair
L	0000045	biological_process	autophagosome assembly
L	0000082	biological_process	G1/S transition of mitotic cell cycle
L	0000165	biological_process	MAPK cascade
L	0000209	biological_process	protein polyubiquitination
L	0000423	biological_process	mitophagy
L	0001837	biological_process	epithelial to mesenchymal transition
L	0004842	molecular_function	ubiquitin-protein transferase activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006281	biological_process	DNA repair
L	0006283	biological_process	transcription-coupled nucleotide-excision repair
L	0006366	biological_process	transcription by RNA polymerase II
L	0006368	biological_process	transcription elongation by RNA polymerase II
L	0006511	biological_process	ubiquitin-dependent protein catabolic process
L	0006513	biological_process	protein monoubiquitination
L	0006915	biological_process	apoptotic process
L	0006974	biological_process	DNA damage response
L	0006979	biological_process	response to oxidative stress
L	0007040	biological_process	lysosome organization
L	0007283	biological_process	spermatogenesis
L	0007346	biological_process	regulation of mitotic cell cycle
L	0008270	molecular_function	zinc ion binding
L	0008286	biological_process	insulin receptor signaling pathway
L	0010507	biological_process	negative regulation of autophagy
L	0010508	biological_process	positive regulation of autophagy
L	0016567	biological_process	protein ubiquitination
L	0016740	molecular_function	transferase activity
L	0019005	cellular_component	SCF ubiquitin ligase complex
L	0019221	biological_process	cytokine-mediated signaling pathway
L	0019788	molecular_function	NEDD8 transferase activity
L	0030163	biological_process	protein catabolic process
L	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
L	0030891	cellular_component	VCB complex
L	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
L	0031461	cellular_component	cullin-RING ubiquitin ligase complex
L	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
L	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
L	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
L	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
L	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
L	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
L	0031625	molecular_function	ubiquitin protein ligase binding
L	0031669	biological_process	cellular response to nutrient levels
L	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
L	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
L	0032480	biological_process	negative regulation of type I interferon production
L	0032481	biological_process	positive regulation of type I interferon production
L	0032869	biological_process	cellular response to insulin stimulus
L	0034198	biological_process	cellular response to amino acid starvation
L	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
L	0034599	biological_process	cellular response to oxidative stress
L	0034644	biological_process	cellular response to UV
L	0035279	biological_process	miRNA-mediated gene silencing by mRNA destabilization
L	0038066	biological_process	p38MAPK cascade
L	0038202	biological_process	TORC1 signaling
L	0042110	biological_process	T cell activation
L	0042770	biological_process	signal transduction in response to DNA damage
L	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
L	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0043687	biological_process	post-translational protein modification
L	0044877	molecular_function	protein-containing complex binding
L	0045116	biological_process	protein neddylation
L	0045727	biological_process	positive regulation of translation
L	0045732	biological_process	positive regulation of protein catabolic process
L	0045944	biological_process	positive regulation of transcription by RNA polymerase II
L	0046627	biological_process	negative regulation of insulin receptor signaling pathway
L	0046872	molecular_function	metal ion binding
L	0060090	molecular_function	molecular adaptor activity
L	0060337	biological_process	type I interferon-mediated signaling pathway
L	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
L	0061630	molecular_function	ubiquitin protein ligase activity
L	0061663	molecular_function	NEDD8 ligase activity
L	0062197	biological_process	cellular response to chemical stress
L	0070294	biological_process	renal sodium ion absorption
L	0070936	biological_process	protein K48-linked ubiquitination
L	0071230	biological_process	cellular response to amino acid stimulus
L	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
L	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
L	0090734	cellular_component	site of DNA damage
L	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
L	0097602	molecular_function	cullin family protein binding
L	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
L	0160240	biological_process	RNA polymerase II transcription initiation surveillance
L	1900076	biological_process	regulation of cellular response to insulin stimulus
L	1901525	biological_process	negative regulation of mitophagy
L	1901797	biological_process	negative regulation of signal transduction by p53 class mediator
L	1902499	biological_process	positive regulation of protein autoubiquitination
L	1902883	biological_process	negative regulation of response to oxidative stress
L	1904037	biological_process	positive regulation of epithelial cell apoptotic process
L	1904262	biological_process	negative regulation of TORC1 signaling
L	1904263	biological_process	positive regulation of TORC1 signaling
L	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process
M	0000781	cellular_component	chromosome, telomeric region
M	0003676	molecular_function	nucleic acid binding
M	0003677	molecular_function	DNA binding
M	0003684	molecular_function	damaged DNA binding
M	0005515	molecular_function	protein binding
M	0005615	cellular_component	extracellular space
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005730	cellular_component	nucleolus
M	0005737	cellular_component	cytoplasm
M	0006281	biological_process	DNA repair
M	0006289	biological_process	nucleotide-excision repair
M	0006511	biological_process	ubiquitin-dependent protein catabolic process
M	0006915	biological_process	apoptotic process
M	0006974	biological_process	DNA damage response
M	0007056	biological_process	spindle assembly involved in female meiosis
M	0010498	biological_process	proteasomal protein catabolic process
M	0016055	biological_process	Wnt signaling pathway
M	0016567	biological_process	protein ubiquitination
M	0019076	biological_process	viral release from host cell
M	0030674	molecular_function	protein-macromolecule adaptor activity
M	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
M	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
M	0032991	cellular_component	protein-containing complex
M	0034644	biological_process	cellular response to UV
M	0035234	biological_process	ectopic germ cell programmed cell death
M	0035861	cellular_component	site of double-strand break
M	0042752	biological_process	regulation of circadian rhythm
M	0043066	biological_process	negative regulation of apoptotic process
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
M	0044725	biological_process	epigenetic programming in the zygotic pronuclei
M	0044877	molecular_function	protein-containing complex binding
M	0045070	biological_process	positive regulation of viral genome replication
M	0045722	biological_process	positive regulation of gluconeogenesis
M	0045732	biological_process	positive regulation of protein catabolic process
M	0046726	biological_process	positive regulation by virus of viral protein levels in host cell
M	0048511	biological_process	rhythmic process
M	0051093	biological_process	negative regulation of developmental process
M	0051702	biological_process	biological process involved in interaction with symbiont
M	0051898	biological_process	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
M	0060337	biological_process	type I interferon-mediated signaling pathway
M	0070062	cellular_component	extracellular exosome
M	0070914	biological_process	UV-damage excision repair
M	0071987	molecular_function	WD40-repeat domain binding
M	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
M	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
M	0097602	molecular_function	cullin family protein binding
M	0160072	molecular_function	ubiquitin ligase complex scaffold activity
M	1901990	biological_process	regulation of mitotic cell cycle phase transition
M	2000242	biological_process	negative regulation of reproductive process
N	0000122	biological_process	negative regulation of transcription by RNA polymerase II
N	0000166	molecular_function	nucleotide binding
N	0001650	cellular_component	fibrillar center
N	0004674	molecular_function	protein serine/threonine kinase activity
N	0005515	molecular_function	protein binding
N	0005524	molecular_function	ATP binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005737	cellular_component	cytoplasm
N	0005813	cellular_component	centrosome
N	0005856	cellular_component	cytoskeleton
N	0006325	biological_process	chromatin organization
N	0006338	biological_process	chromatin remodeling
N	0008180	cellular_component	COP9 signalosome
N	0016301	molecular_function	kinase activity
N	0016567	biological_process	protein ubiquitination
N	0016740	molecular_function	transferase activity
N	0030183	biological_process	B cell differentiation
N	0030331	molecular_function	nuclear estrogen receptor binding
N	0033151	biological_process	V(D)J recombination
N	0035212	biological_process	cell competition in a multicellular organism
N	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
N	0043687	biological_process	post-translational protein modification
N	0045732	biological_process	positive regulation of protein catabolic process
N	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
N	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
N	0106310	molecular_function	protein serine kinase activity
N	1990244	molecular_function	histone H2AT120 kinase activity
N	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
O	0000082	biological_process	G1/S transition of mitotic cell cycle
O	0001701	biological_process	in utero embryonic development
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0006281	biological_process	DNA repair
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
O	0006974	biological_process	DNA damage response
O	0007283	biological_process	spermatogenesis
O	0008283	biological_process	cell population proliferation
O	0008284	biological_process	positive regulation of cell population proliferation
O	0016567	biological_process	protein ubiquitination
O	0030097	biological_process	hemopoiesis
O	0030853	biological_process	negative regulation of granulocyte differentiation
O	0031461	cellular_component	cullin-RING ubiquitin ligase complex
O	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
O	0031625	molecular_function	ubiquitin protein ligase binding
O	0032502	biological_process	developmental process
O	0034644	biological_process	cellular response to UV
O	0035019	biological_process	somatic stem cell population maintenance
O	0035279	biological_process	miRNA-mediated gene silencing by mRNA destabilization
O	0042110	biological_process	T cell activation
O	0042254	biological_process	ribosome biogenesis
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0045732	biological_process	positive regulation of protein catabolic process
O	0048511	biological_process	rhythmic process
O	0051246	biological_process	regulation of protein metabolic process
O	0060337	biological_process	type I interferon-mediated signaling pathway
O	0061630	molecular_function	ubiquitin protein ligase activity
O	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
O	0097193	biological_process	intrinsic apoptotic signaling pathway
O	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
O	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
O	0160072	molecular_function	ubiquitin ligase complex scaffold activity
O	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle
O	2000001	biological_process	regulation of DNA damage checkpoint
O	2000819	biological_process	regulation of nucleotide-excision repair
P	0000045	biological_process	autophagosome assembly
P	0000082	biological_process	G1/S transition of mitotic cell cycle
P	0000165	biological_process	MAPK cascade
P	0000209	biological_process	protein polyubiquitination
P	0000423	biological_process	mitophagy
P	0001837	biological_process	epithelial to mesenchymal transition
P	0004842	molecular_function	ubiquitin-protein transferase activity
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006281	biological_process	DNA repair
P	0006283	biological_process	transcription-coupled nucleotide-excision repair
P	0006366	biological_process	transcription by RNA polymerase II
P	0006368	biological_process	transcription elongation by RNA polymerase II
P	0006511	biological_process	ubiquitin-dependent protein catabolic process
P	0006513	biological_process	protein monoubiquitination
P	0006915	biological_process	apoptotic process
P	0006974	biological_process	DNA damage response
P	0006979	biological_process	response to oxidative stress
P	0007040	biological_process	lysosome organization
P	0007283	biological_process	spermatogenesis
P	0007346	biological_process	regulation of mitotic cell cycle
P	0008270	molecular_function	zinc ion binding
P	0008286	biological_process	insulin receptor signaling pathway
P	0010507	biological_process	negative regulation of autophagy
P	0010508	biological_process	positive regulation of autophagy
P	0016567	biological_process	protein ubiquitination
P	0016740	molecular_function	transferase activity
P	0019005	cellular_component	SCF ubiquitin ligase complex
P	0019221	biological_process	cytokine-mediated signaling pathway
P	0019788	molecular_function	NEDD8 transferase activity
P	0030163	biological_process	protein catabolic process
P	0030330	biological_process	DNA damage response, signal transduction by p53 class mediator
P	0030891	cellular_component	VCB complex
P	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
P	0031461	cellular_component	cullin-RING ubiquitin ligase complex
P	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
P	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
P	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
P	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
P	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
P	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
P	0031625	molecular_function	ubiquitin protein ligase binding
P	0031669	biological_process	cellular response to nutrient levels
P	0032435	biological_process	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
P	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
P	0032480	biological_process	negative regulation of type I interferon production
P	0032481	biological_process	positive regulation of type I interferon production
P	0032869	biological_process	cellular response to insulin stimulus
P	0034198	biological_process	cellular response to amino acid starvation
P	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
P	0034599	biological_process	cellular response to oxidative stress
P	0034644	biological_process	cellular response to UV
P	0035279	biological_process	miRNA-mediated gene silencing by mRNA destabilization
P	0038066	biological_process	p38MAPK cascade
P	0038202	biological_process	TORC1 signaling
P	0042110	biological_process	T cell activation
P	0042770	biological_process	signal transduction in response to DNA damage
P	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
P	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0043687	biological_process	post-translational protein modification
P	0044877	molecular_function	protein-containing complex binding
P	0045116	biological_process	protein neddylation
P	0045727	biological_process	positive regulation of translation
P	0045732	biological_process	positive regulation of protein catabolic process
P	0045944	biological_process	positive regulation of transcription by RNA polymerase II
P	0046627	biological_process	negative regulation of insulin receptor signaling pathway
P	0046872	molecular_function	metal ion binding
P	0060090	molecular_function	molecular adaptor activity
P	0060337	biological_process	type I interferon-mediated signaling pathway
P	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
P	0061630	molecular_function	ubiquitin protein ligase activity
P	0061663	molecular_function	NEDD8 ligase activity
P	0062197	biological_process	cellular response to chemical stress
P	0070294	biological_process	renal sodium ion absorption
P	0070936	biological_process	protein K48-linked ubiquitination
P	0071230	biological_process	cellular response to amino acid stimulus
P	0080008	cellular_component	Cul4-RING E3 ubiquitin ligase complex
P	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
P	0090734	cellular_component	site of DNA damage
P	0097510	biological_process	base-excision repair, AP site formation via deaminated base removal
P	0097602	molecular_function	cullin family protein binding
P	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
P	0160240	biological_process	RNA polymerase II transcription initiation surveillance
P	1900076	biological_process	regulation of cellular response to insulin stimulus
P	1901525	biological_process	negative regulation of mitophagy
P	1901797	biological_process	negative regulation of signal transduction by p53 class mediator
P	1902499	biological_process	positive regulation of protein autoubiquitination
P	1902883	biological_process	negative regulation of response to oxidative stress
P	1904037	biological_process	positive regulation of epithelial cell apoptotic process
P	1904262	biological_process	negative regulation of TORC1 signaling
P	1904263	biological_process	positive regulation of TORC1 signaling
P	2000059	biological_process	negative regulation of ubiquitin-dependent protein catabolic process

Functional Information from PROSITE/UniProt

site_id	PS01256
Number of Residues	28
Details	CULLIN_1 Cullin family signature. LKkrIesLIDRdYMeRdkdnpnqYhYvA

Chain	Residue	Details
C	LEU732-ALA759

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3064
Details	Region: {"description":"Interaction with CDT1","evidences":[{"source":"PubMed","id":"15448697","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1372
Details	Region: {"description":"WD repeat beta-propeller A"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1264
Details	Region: {"description":"WD repeat beta-propeller B; Interaction with CUL4A"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9ESW0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	156
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

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site_id	SWS_FT_FI9
Number of Residues	164
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

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site_id	SWS_FT_FI10
Number of Residues	148
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	128
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

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site_id	SWS_FT_FI12
Number of Residues	168
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

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site_id	SWS_FT_FI13
Number of Residues	796
Details	Region: {"description":"WD repeat-like region"}

Chain

Residue

Details

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site_id	SWS_FT_FI14
Number of Residues	28
Details	Motif: {"description":"DWD box 1"}

Chain

Residue

Details

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site_id	SWS_FT_FI15
Number of Residues	28
Details	Motif: {"description":"DWD box 2"}

Chain

Residue

Details

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site_id	SWS_FT_FI16
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI17
Number of Residues	240
Details	Domain: {"description":"Cullin neddylation","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI18
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)","evidences":[{"source":"PubMed","id":"38316879","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI19
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Z8B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11961546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38605244","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LDJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LDK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U6G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HYE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DQV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RTR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4F52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4P5O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8Q7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8RHZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

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---