PDB: 7770 件ウェブページステータス検索Chemie searchBIRD

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3E6V	X-ray structure of human arginase I-D183N mutant: the complex with ABH 分子名称: 2(S)-AMINO-6-BORONOHEXANOIC ACID, Arginase-1, MANGANESE (II) ION 著者 Di Costanzo, L, Christianson, D.W. 登録日 2008-08-16 公開日 2008-12-02 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Probing the specificity determinants of amino acid recognition by arginase. Biochemistry, 48, 2009
3EAB	Crystal structure of Spastin MIT in complex with ESCRT III 分子名称: CHMP1b, Spastin 著者 Yang, D, Rimanchi, N, Renvoise, B, Lippincott-Schwartz, J, Blackstone, C, Hurley, J.H. 登録日 2008-08-25 公開日 2008-11-11 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B. Nat.Struct.Mol.Biol., 15, 2008
3EBF	Structure of inhibited murine iNOS oxygenase domain 分子名称: (3R)-3-[(1,2,3,4-tetrahydroisoquinolin-7-yloxy)methyl]-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, Nitric oxide synthase, ... 著者 Garcin, E.D, Arvai, A.S, Rosenfeld, R.J, Kroeger, M.D, Crane, B.R, Andersson, G, Andrews, G, Hamley, P.J, Mallinder, P.R, Nicholls, D.J, St-Gallay, S.A, Tinker, A.C, Gensmantel, N.P, Mete, A, Cheshire, D.R, Connolly, S, Stuehr, D.J, Aberg, A, Wallace, A.V, Tainer, J.A, Getzoff, E.D. 登録日 2008-08-27 公開日 2008-10-07 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat.Chem.Biol., 4, 2008
3EFK	Structure of c-Met with pyrimidone inhibitor 50 分子名称: 5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-2-[(4-fluorophenyl)amino]-3-methylpyrimidin-4(3H)-one, Hepatocyte growth factor receptor 著者 Bellon, S.F, D'Angelo, N, Whittington, D, Dussault, I. 登録日 2008-09-09 公開日 2008-10-07 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Design, synthesis, and biological evaluation of potent c-Met inhibitors. J.Med.Chem., 51, 2008
3EH9	Crystal structure of death associated protein kinase complexed with ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, Death-associated protein kinase 1, SULFATE ION 著者 McNamara, L.K, Watterson, D.M, Brunzelle, J.S. 登録日 2008-09-11 公開日 2009-04-28 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural insight into nucleotide recognition by human death-associated protein kinase. Acta Crystallogr.,Sect.D, 65, 2009
3EO1	Structure of the Fab Fragment of GC-1008 in Complex with Transforming Growth Factor-Beta 3 分子名称: GC-1008 Fab Heavy Chain, GC-1008 Fab Light Chain, Transforming growth factor beta-3 著者 Gruetter, C, Gruetter, M.G. 登録日 2008-09-26 公開日 2008-12-02 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions Proc.Natl.Acad.Sci.Usa, 105, 2008
3EBD	Structure of inhibited murine iNOS oxygenase domain 分子名称: (2S)-2-methyl-2,3-dihydrothieno[2,3-f][1,4]oxazepin-5-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, Nitric oxide synthase, ... 著者 Garcin, E.D, Arvai, A.S, Rosenfeld, R.J, Kroeger, M.D, Crane, B.R, Andersson, G, Andrews, G, Hamley, P.J, Mallinder, P.R, Nicholls, D.J, St-Gallay, S.A, Tinker, A.C, Gensmantel, N.P, Mete, A, Cheshire, D.R, Connolly, S, Stuehr, D.J, Aberg, A, Wallace, A.V, Tainer, J.A, Getzoff, E.D. 登録日 2008-08-27 公開日 2008-10-07 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat.Chem.Biol., 4, 2008
3EFJ	Structure of c-Met with pyrimidone inhibitor 7 分子名称: 2-benzyl-5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-3-methylpyrimidin-4(3H)-one, Hepatocyte growth factor receptor 著者 D'Angelo, N, Bellon, S, Whittington, D. 登録日 2008-09-09 公開日 2008-10-07 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Design, synthesis, and biological evaluation of potent c-Met inhibitors. J.Med.Chem., 51, 2008
3EHQ	Crystal Structure of Human Osteoclast Stimulating Factor 分子名称: 1,2-ETHANEDIOL, Osteoclast-stimulating factor 1 著者 Tong, S, Zhou, H, Gao, Y, Zhu, Z, Zhang, X, Teng, M, Niu, L. 登録日 2008-09-14 公開日 2009-08-04 最終更新日 2021-11-10 実験手法 X-RAY DIFFRACTION (2.57 Å) 主引用文献 Crystal structure of human osteoclast stimulating factor Proteins, 75, 2009
3E6N	Structure of murine INOS oxygenase domain with inhibitor AR-C125813 分子名称: 4-METHYL-6-PROPYLPYRIDIN-2-AMINE, 5,6,7,8-TETRAHYDROBIOPTERIN, Nitric oxide synthase, ... 著者 Garcin, E.D, Arvai, A.S, Rosenfeld, R.J, Kroeger, M.D, Crane, B.R, Andersson, G, Andrews, G, Hamley, P.J, Mallinder, P.R, Nicholls, D.J, St-Gallay, S.A, Tinker, A.C, Gensmantel, N.P, Mete, A, Cheshire, D.R, Connolly, S, Stueh, D.J, Aberg, A, Wallace, A.V, Tainer, J.A, Getzoff, E.D. 登録日 2008-08-15 公開日 2008-10-07 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat.Chem.Biol., 4, 2008
3EDV	Crystal Structure of Repeats 14-16 of Beta2-Spectrin 分子名称: MAGNESIUM ION, Spectrin beta chain, brain 1 著者 Michaely, P, Tomchick, D.R. 登録日 2008-09-03 公開日 2009-01-20 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.951 Å) 主引用文献 Localization and Structure of the Ankyrin-binding Site on beta2-Spectrin J.Biol.Chem., 284, 2009
3EHA	Crystal structure of death associated protein kinase complexed with AMPPNP 分子名称: Death-associated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 McNamara, L.K, Watterson, D.M, Brunzelle, J.S. 登録日 2008-09-11 公開日 2009-04-28 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural insight into nucleotide recognition by human death-associated protein kinase. Acta Crystallogr.,Sect.D, 65, 2009
3EJ8	Structure of double mutant of human iNOS oxygenase domain with bound immidazole 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, HEME C, IMIDAZOLE, ... 著者 Garcin, E.D, Arvai, A.S, Rosenfeld, R.J, Kroeger, M.D, Crane, B.R, Andersson, G, Andrews, G, Hamley, P.J, Mallinder, P.R, Nicholls, D.J, St-Gallay, S.A, Tinker, A.C, Gensmantel, N.P, Mete, A, Cheshire, D.R, Connolly, S, Stuehr, D.J, Aberg, A, Wallace, A.V, Tainer, J.A, Getzoff, E.D. 登録日 2008-09-17 公開日 2008-10-07 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat.Chem.Biol., 4, 2008
3EOB	Crystal structure the Fab fragment of Efalizumab in complex with LFA-1 I domain, Form II 分子名称: Efalizumab Fab fragment, heavy chain, light chain, ... 著者 Li, S, Ding, J. 登録日 2008-09-26 公開日 2009-04-14 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Efalizumab binding to the LFA-1 alphaL I domain blocks ICAM-1 binding via steric hindrance. Proc.Natl.Acad.Sci.USA, 106, 2009
3EQP	Crystal Structure of Ack1 with compound T95 分子名称: Activated CDC42 kinase 1, CHLORIDE ION, N-(2,6-dimethylphenyl)-4-(2-ethoxyphenoxy)-2-({4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl}amino)pyrimidine-5-carboxamide 著者 Liu, J, Wang, Z, Walker, N.P.C. 登録日 2008-10-01 公開日 2008-12-02 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Identification and optimization of N3,N6-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors. Bioorg.Med.Chem.Lett., 18, 2008
3EU0	Crystal structure of the S-nitrosylated Cys215 of PTP1B 分子名称: Tyrosine-protein phosphatase non-receptor type 1 著者 Chu, H.M, Wang, A.H.J, Chen, Y.Y, Pan, K.T, Wang, D.L, Khoo, K.H, Meng, T.C. 登録日 2008-10-09 公開日 2008-11-11 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Cysteine S-Nitrosylation Protects Protein-tyrosine Phosphatase 1B against Oxidation-induced Permanent Inactivation J.Biol.Chem., 283, 2008
3EQ6	Crystal structure of human acyl-CoA synthetase medium-chain family member 2A (L64P mutation) in a ternary complex with products 分子名称: ADENOSINE MONOPHOSPHATE, Acyl-coenzyme A synthetase ACSM2A, Butyryl Coenzyme A 著者 Pilka, E.S, Kochan, G, Yue, W.W, Bhatia, C, Von delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Oppermann, U, Structural Genomics Consortium (SGC) 登録日 2008-09-30 公開日 2008-10-28 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A J.Mol.Biol., 388, 2009
3E5M	Crystal structure of the HSCARG Y81A mutant 分子名称: NmrA-like family domain-containing protein 1 著者 Li, Y, Meng, G, Dai, X, Luo, M, Zheng, X. 登録日 2008-08-14 公開日 2009-05-12 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 NADPH is an allosteric regulator of HSCARG J.Mol.Biol., 387, 2009
3E6O	Structure of murine INOS oxygenase domain with inhibitor AR-C124355 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, N-[2-(4-AMINO-5,8-DIFLUORO-1,2-DIHYDROQUINAZOLIN-2-YL)ETHYL]-3-FURAMIDE, Nitric oxide synthase, ... 著者 Garcin, E.D, Arvai, A.S, Rosenfeld, R.J, Kroeger, M.D, Crane, B.R, Andersson, G, Andrews, G, Hamley, P.J, Mallinder, P.R, Nicholls, D.J, St-Gallay, S.A, Tinker, A.C, Gensmantel, N.P, Mete, A, Cheshire, D.R, Connolly, S, Stueh, D.J, Aberg, A, Wallace, A.V, Tainer, J.A, Getzoff, E.D. 登録日 2008-08-15 公開日 2008-10-07 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat.Chem.Biol., 4, 2008
3E50	Crystal structure of human insulin degrading enzyme in complex with transforming growth factor-alpha 分子名称: Insulin-degrading enzyme, Protransforming growth factor alpha, ZINC ION 著者 Guo, Q, Manolopoulou, M, Tang, W.-J. 登録日 2008-08-12 公開日 2009-08-18 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme. J.Mol.Biol., 395, 2010
3EB1	Crystal structure PTP1B complex with small molecule inhibitor LZP-25 分子名称: 4-[3-(dibenzylamino)phenyl]-2,4-dioxobutanoic acid, Tyrosine-protein phosphatase non-receptor type 1 著者 Liu, S, Zheng, L.-F, Wu, L, Yu, X, Xue, T, Gunawan, A.M, Long, Y.-Q, Zhang, Z.-Y. 登録日 2008-08-26 公開日 2009-07-07 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors. J.Am.Chem.Soc., 130, 2008
3EAH	Structure of inhibited human eNOS oxygenase domain 分子名称: (3S,5E)-3-propyl-3,4-dihydrothieno[2,3-f][1,4]oxazepin-5(2H)-imine, (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, ... 著者 Garcin, E.D, Arvai, A.S, Rosenfeld, R.J, Kroeger, M.D, Crane, B.R, Andersson, G, Andrews, G, Hamley, P.J, Mallinder, P.R, Nicholls, D.J, St-Gallay, S.A, Tinker, A.C, Gensmantel, N.P, Mete, A, Cheshire, D.R, Connolly, S, Stuehr, D.J, Aberg, A, Wallace, A.V, Tainer, J.A, Getzoff, E.D. 登録日 2008-08-25 公開日 2008-10-07 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat.Chem.Biol., 4, 2008
3EFI	Carbonic anhydrase activators: Kinetic and X-ray crystallographic study for the interaction of d- and l-tryptophan with the mammalian isoforms I-XIV 分子名称: Carbonic anhydrase 2, MERCURIBENZOIC ACID, TRYPTOPHAN, ... 著者 Temperini, C, Innocenti, A, Scozzafava, A, Supuran, C.T. 登録日 2008-09-09 公開日 2008-09-30 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV Bioorg.Med.Chem., 16, 2008
3GL6	Crystal structure of JARID1A-PHD3 complexed with H3(1-9)K4me3 peptide 分子名称: Histone H3, Histone demethylase JARID1A, ZINC ION 著者 Wang, Z, Song, J, Patel, D.J. 登録日 2009-03-11 公開日 2009-05-05 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature, 459, 2009
3HAI	Crystal structure of human PACSIN1 F-BAR domain (P21 lattice) 分子名称: CALCIUM ION, human PACSIN1 F-BAR 著者 Wang, Q, Navarro, M.V.A.S, Peng, G, Rajashankar, K.R, Sondermann, H. 登録日 2009-05-01 公開日 2009-06-16 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.881 Å) 主引用文献 Molecular mechanism of membrane constriction and tubulation mediated by the F-BAR protein Pacsin/Syndapin. Proc.Natl.Acad.Sci.USA, 106, 2009

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