3E6O

Structure of murine INOS oxygenase domain with inhibitor AR-C124355

Summary for 3E6O

Entry DOI	10.2210/pdb3e6o/pdb
Related	3E65 3E67 3E68 3E6L 3E6N 3E6T 3E7G
Descriptor	Nitric oxide synthase, inducible, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (5 entities in total)
Functional Keywords	nitric oxide, nos, heme, tetrahydrobiopterin, oxidoreductase, calmodulin-binding, fad, fmn, iron, metal-binding, nadp, polymorphism, zinc
Biological source	Mus musculus (mouse)
Total number of polymer chains	2
Total formula weight	102597.96
Authors	Garcin, E.D.,Arvai, A.S.,Rosenfeld, R.J.,Kroeger, M.D.,Crane, B.R.,Andersson, G.,Andrews, G.,Hamley, P.J.,Mallinder, P.R.,Nicholls, D.J.,St-Gallay, S.A.,Tinker, A.C.,Gensmantel, N.P.,Mete, A.,Cheshire, D.R.,Connolly, S.,Stueh, D.J.,Aberg, A.,Wallace, A.V.,Tainer, J.A.,Getzoff, E.D. (deposition date: 2008-08-15, release date: 2008-10-07, Last modification date: 2024-02-21)
Primary citation	Garcin, E.D.,Arvai, A.S.,Rosenfeld, R.J.,Kroeger, M.D.,Crane, B.R.,Andersson, G.,Andrews, G.,Hamley, P.J.,Mallinder, P.R.,Nicholls, D.J.,St-Gallay, S.A.,Tinker, A.C.,Gensmantel, N.P.,Mete, A.,Cheshire, D.R.,Connolly, S.,Stuehr, D.J.,Aberg, A.,Wallace, A.V.,Tainer, J.A.,Getzoff, E.D. Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat.Chem.Biol., 4:700-707, 2008 Cited by PubMed: 18849972 DOI: 10.1038/nchembio.115 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation