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3EAH

Structure of inhibited human eNOS oxygenase domain

Summary for 3EAH
Entry DOI10.2210/pdb3eah/pdb
Related3E65 3E67 3E68 3E6L 3E6N 3E6O 3E6T 3E7G 3E7I 3E7M 3E7S 3E7T 3EAI 3EBD 3EBF 3EJ8
DescriptorNitric oxide synthase, endothelial, HEME C, ZINC ION, ... (7 entities in total)
Functional Keywordsnitric oxide synthase, nos, heme, tetrahydrobiopterin, oxidoreductase calmodulin-binding, fad, fmn, iron, metal-binding, nadp, oxidoreductase, polymorphism, zinc
Biological sourceHomo sapiens (human)
Cellular locationCell membrane: P29474
Total number of polymer chains2
Total formula weight98305.40
Authors
Primary citationGarcin, E.D.,Arvai, A.S.,Rosenfeld, R.J.,Kroeger, M.D.,Crane, B.R.,Andersson, G.,Andrews, G.,Hamley, P.J.,Mallinder, P.R.,Nicholls, D.J.,St-Gallay, S.A.,Tinker, A.C.,Gensmantel, N.P.,Mete, A.,Cheshire, D.R.,Connolly, S.,Stuehr, D.J.,Aberg, A.,Wallace, A.V.,Tainer, J.A.,Getzoff, E.D.
Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.
Nat.Chem.Biol., 4:700-707, 2008
Cited by
PubMed: 18849972
DOI: 10.1038/nchembio.115
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.44 Å)
Structure validation

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