3EJ8
Structure of double mutant of human iNOS oxygenase domain with bound immidazole
Summary for 3EJ8
Entry DOI | 10.2210/pdb3ej8/pdb |
Related | 3E65 3E67 3E68 3E6L 3E6N 3E6O 3E6T 3E7G 3E7I 3E7M 3E7S 3E7T 3EAH 3EAI 3EBD 3EBF |
Descriptor | Nitric oxide synthase, inducible, HEME C, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (6 entities in total) |
Functional Keywords | nitric oxide synthase, nos, heme, tetrahydrobiopterin, oxidoreductase calmodulin-binding, fad, fmn, iron, metal-binding, nadp, oxidoreductase, polymorphism, zinc |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 199965.66 |
Authors | Garcin, E.D.,Arvai, A.S.,Rosenfeld, R.J.,Kroeger, M.D.,Crane, B.R.,Andersson, G.,Andrews, G.,Hamley, P.J.,Mallinder, P.R.,Nicholls, D.J.,St-Gallay, S.A.,Tinker, A.C.,Gensmantel, N.P.,Mete, A.,Cheshire, D.R.,Connolly, S.,Stuehr, D.J.,Aberg, A.,Wallace, A.V.,Tainer, J.A.,Getzoff, E.D. (deposition date: 2008-09-17, release date: 2008-10-07, Last modification date: 2024-02-21) |
Primary citation | Garcin, E.D.,Arvai, A.S.,Rosenfeld, R.J.,Kroeger, M.D.,Crane, B.R.,Andersson, G.,Andrews, G.,Hamley, P.J.,Mallinder, P.R.,Nicholls, D.J.,St-Gallay, S.A.,Tinker, A.C.,Gensmantel, N.P.,Mete, A.,Cheshire, D.R.,Connolly, S.,Stuehr, D.J.,Aberg, A.,Wallace, A.V.,Tainer, J.A.,Getzoff, E.D. Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat.Chem.Biol., 4:700-707, 2008 Cited by PubMed: 18849972DOI: 10.1038/nchembio.115 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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