3EJ8
Structure of double mutant of human iNOS oxygenase domain with bound immidazole
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Nitric oxide synthase, inducible | polymer | 424 | 49029.9 | 4 | UniProt (P35228) Pfam (PF02898) | Homo sapiens (human) | NOS TYPE II, INDUCIBLE NOS, INOS, Inducible NO synthase, Hepatocyte NOS, HEP-NOS |
| 2 | E, I, L, P (A, B, C, D) | HEME C | non-polymer | 618.5 | 4 | Chemie (HEC) | |||
| 3 | F, J, M, Q (A, B, C, D) | 5,6,7,8-TETRAHYDROBIOPTERIN | non-polymer | 241.2 | 4 | Chemie (H4B) | |||
| 4 | G, N (A, C) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | H, K, O, R (A, B, C, D) | IMIDAZOLE | non-polymer | 69.1 | 4 | Chemie (IMD) | |||
| 6 | S, T, U, V (A, B, C, D) | water | water | 18.0 | 193 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 82 - 505 (UniProt: P35228)
| PDB | External Database | Details |
|---|---|---|
| Ile 286 | Phe 286 | engineered mutation |
| Leu 305 | Val 305 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 196119.5 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 3846.2 | |
| All* | Total formula weight | 199965.7 |
