PDB: 12060 件ウェブページステータス検索Chemie searchBIRD

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5DKI	Yeast 20S proteasome in complex with alkyne-PI 分子名称: CHLORIDE ION, MAGNESIUM ION, Probable proteasome subunit alpha type-7, ... 著者 Beck, P, Cui, H, Groll, M. 登録日 2015-09-03 公開日 2015-10-28 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Targeted Delivery of Proteasome Inhibitors to Somatostatin-Receptor-Expressing Cancer Cells by Octreotide Conjugation. Chemmedchem, 10, 2015
4ZHK	Crystal structure of RPE65 in complex with MB-002 分子名称: (1R)-1-[3-(cyclohexylmethoxy)phenyl]propane-1,3-diol, (1S)-1-[3-(cyclohexylmethoxy)phenyl]propane-1,3-diol, FE (II) ION, ... 著者 Kiser, P.D, Palczewski, K. 登録日 2015-04-25 公開日 2015-05-27 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Molecular pharmacodynamics of emixustat in protection against retinal degeneration. J.Clin.Invest., 125, 2015
5DMJ	Structure of the extracellular domain of the CD40 in complex with 3H56-5 DAB 分子名称: 3H65-5 domain antibody (dAb), POTASSIUM ION, Tumor necrosis factor receptor superfamily member 5 著者 Sheriff, S. 登録日 2015-09-08 公開日 2016-06-01 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.79 Å) 主引用文献 Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope. J.Mol.Biol., 428, 2016
5DNE	Crystal structure of the Asn-bound guinea pig L-asparaginase 1 catalytic domain active site mutant K188M 分子名称: 1,2-ETHANEDIOL, ASPARAGINE, L-asparaginase 著者 Schalk, A.M, Lavie, A. 登録日 2015-09-10 公開日 2016-01-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Experimental Data in Support of a Direct Displacement Mechanism for Type I/II l-Asparaginases. J.Biol.Chem., 291, 2016
4Z0X	Structure of Hepatitis C Virus Envelope glycoprotein E2 antigenic region 434-446 bound to the broadly neutralizing antibody HC26AM 分子名称: Antibody HC26AM heavy chain variable domain, Antibody HC26AM light chain variable domain, HCV E2 Antigen (residues 432-446) 著者 Rangarajan, S, Shahid, S, Mariuzza, R.A. 登録日 2015-03-26 公開日 2016-07-20 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Affinity maturation of a broadly neutralizing human monoclonal antibody that prevents acute hepatitis C virus infection in mice. Hepatology, 64, 2016
4BL3	Crystal structure of PBP2a clinical mutant N146K from MRSA 分子名称: CADMIUM ION, CHLORIDE ION, PENICILLIN BINDING PROTEIN 2 PRIME, ... 著者 Otero, L.H, Rojas-Altuve, A, Carrasco-Lopez, C, Hermoso, J.A. 登録日 2013-04-30 公開日 2014-05-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics. J.Am.Chem.Soc., 136, 2014
2PC0	Apo Wild-type HIV Protease in the open conformation 分子名称: MAGNESIUM ION, Protease, R-1,2-PROPANEDIOL 著者 Heaslet, H, Rosenfeld, R, Giffin, M.J, Elder, J.H, McRee, D.E, Stout, C.D. 登録日 2007-03-29 公開日 2007-06-26 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Conformational flexibility in the flap domains of ligand-free HIV protease. Acta Crystallogr.,Sect.D, 63, 2007
2P1V	Crystal structure of the ligand binding domain of the retinoid X receptor alpha in complex with 3-(2'-propoxy)-tetrahydronaphtyl cinnamic acid and a fragment of the coactivator TIF-2 分子名称: (2E)-3-[4-HYDROXY-3-(5,5,8,8-TETRAMETHYL-3-PROPOXY-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)PHENYL]ACRYLIC ACID, Nuclear receptor coactivator 2 peptide, Retinoic acid receptor RXR-alpha 著者 Bourguet, W, Nahoum, V. 登録日 2007-03-06 公開日 2007-10-09 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function. Proc.Natl.Acad.Sci.Usa, 104, 2007
7UMO	Structure of Unc119-inhibitor complex. 分子名称: (3s,5s,7s)-N-(4,5-dichloropyridin-2-yl)adamantane-1-carboxamide, GLYCEROL, Protein unc-119 homolog A 著者 Srivastava, D, Sebag, J.A, Artemyev, N.O. 登録日 2022-04-07 公開日 2023-07-26 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Insulin sensitization by small molecules enhancing GLUT4 translocation. Cell Chem Biol, 30, 2023
4BB6	Free-Wilson and Structural Approaches to Co-optimising Human and Rodent Isoform Potency for 11b-Hydroxysteroid Dehydrogenase Type 1 11b-HSD1 Inhibitors 分子名称: 6-(4-methylpiperazin-1-yl)-N-[(1R,3S)-5-oxidanyl-2-adamantyl]-2-propylsulfanyl-pyridine-3-carboxamide, CHLORIDE ION, CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1, ... 著者 Goldberg, F.W, Leach, A.G, Scott, J.S, Snelson, W.L, Groombridge, S.D, Donald, C.S, Bennett, S.N.L, Bodin, C, Morentin Gutierrez, P, Gyte, A.C. 登録日 2012-09-20 公開日 2012-11-28 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Free-Wilson and Structural Approaches to Co- Optimising Human and Rodent Isoform Potency for 11Beta-Hydroxysteroid Dehydrogenase Type 1 (11Beta-Hsd1) Inhibitors J.Med.Chem., 55, 2012
2PEQ	Crystal structure of RbcX, crystal form II 分子名称: ORF134 著者 Saschenbrecker, S, Bracher, A, Vasudeva Rao, K, Vasudeva Rao, B, Hartl, F.U, Hayer-Hartl, M. 登録日 2007-04-03 公開日 2007-07-10 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure and Function of RbcX, an Assembly Chaperone for Hexadecameric Rubisco. Cell(Cambridge,Mass.), 129, 2007
4BCK	Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor 分子名称: 3-[[5-cyano-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]benzenesulfonamide, CYCLIN-A2, CYCLIN-DEPENDENT KINASE 2, ... 著者 Hole, A.J, Baumli, S, Wang, S, Endicott, J.A, Noble, M.E.M. 登録日 2012-10-02 公開日 2013-03-06 実験手法 X-RAY DIFFRACTION (2.052 Å) 主引用文献 Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity. J.Med.Chem., 56, 2013
2P1T	Crystal structure of the ligand binding domain of the retinoid X receptor alpha in complex with 3-(2'-methoxy)-tetrahydronaphtyl cinnamic acid and a fragment of the coactivator TIF-2 分子名称: (2E)-3-[4-HYDROXY-3-(3-METHOXY-5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)PHENYL]ACRYLIC ACID, Nuclear receptor coactivator 2 peptide, Retinoic acid receptor RXR-alpha 著者 Bourguet, W, Nahoum, V. 登録日 2007-03-06 公開日 2007-10-09 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function. Proc.Natl.Acad.Sci.Usa, 104, 2007
2PEM	Crystal structure of RbcX in complex with substrate 分子名称: ORF134, RbcL 著者 Saschenbrecker, S, Bracher, A, Vasudeva Rao, K, Vasudeva Rao, B, Hartl, F.U, Hayer-Hartl, M. 登録日 2007-04-03 公開日 2007-07-10 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Structure and Function of RbcX, an Assembly Chaperone for Hexadecameric Rubisco. Cell(Cambridge,Mass.), 129, 2007
5DRW	Crystal structure of the BCR Fab fragment from subset #4 case CLL183 分子名称: CLL183 BCR antibody heavy chain, CLL183 BCR antibody light chain 著者 Minici, C, Degano, M. 登録日 2015-09-16 公開日 2016-09-28 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Distinct homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia. Nat Commun, 8, 2017
4BC0	Structure of mouse acetylcholinesterase inhibited by CBDP (12-h soak) : Cresyl-phosphoserine adduct 分子名称: (2-methylphenyl) dihydrogen phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE, ... 著者 Carletti, E, Colletier, J.-P, Schopfer, L.M, Santoni, G, Masson, P, Lockridge, O, Nachon, F, Weik, M. 登録日 2012-09-30 公開日 2013-02-06 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 Inhibition Pathways of the Potent Organophosphate Cbdp with Cholinesterases Revealed by X-Ray Crystallographic Snapshots and Mass Spectrometry Chem.Res.Toxicol., 26, 2013
4BCJ	Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor 分子名称: 2-[(3-hydroxyphenyl)amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile, CYCLIN-DEPENDENT KINASE 9, CYCLIN-T1 著者 Hole, A.J, Baumli, S, Wang, S, Endicott, J.A, Noble, M.E.M. 登録日 2012-10-02 公開日 2013-01-09 最終更新日 2019-05-15 実験手法 X-RAY DIFFRACTION (3.162 Å) 主引用文献 Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity. J.Med.Chem., 56, 2013
5AUZ	Crystal structure of DAPK1 in complex with genistein. 分子名称: Death-associated protein kinase 1, GENISTEIN 著者 Yokoyama, T, Mizuguchi, M. 登録日 2015-06-10 公開日 2015-10-07 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural Insight into the Interactions between Death-Associated Protein Kinase 1 and Natural Flavonoids. J.Med.Chem., 58, 2015
2PEI	Crystal structure of selenomethionine-labeled RbcX 分子名称: ORF134 著者 Saschenbrecker, S, Bracher, A, Vasudeva Rao, K, Vasudeva Rao, B, Hartl, F.U, Hayer-Hartl, M. 登録日 2007-04-03 公開日 2007-07-10 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structure and Function of RbcX, an Assembly Chaperone for Hexadecameric Rubisco. Cell(Cambridge,Mass.), 129, 2007
4ZA0	Structure of Human Enolase 2 in complex with Phosphonoacetohydroxamate 分子名称: Gamma-enolase, MAGNESIUM ION, PHOSPHONOACETOHYDROXAMIC ACID 著者 Leonard, P.G, Maxwell, D, Czako, B, Muller, F.L. 登録日 2015-04-13 公開日 2016-04-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 SF2312 is a natural phosphonate inhibitor of enolase. Nat.Chem.Biol., 12, 2016
4BIA	Crystal structure of SCP2 thiolase from Trypanosoma brucei: The C337A mutant. 分子名称: 3-KETOACYL-COA THIOLASE, PUTATIVE 著者 Harijan, R.K, Kiema, T.-R, Weiss, M.S, Michels, P.A.M, Wierenga, R.K. 登録日 2013-04-10 公開日 2013-08-14 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal Structures of Scp2-Thiolases of Trypanosomatidae, Human Pathogens Causing Widespread Tropical Diseases: The Importance for Catalysis of the Cysteine of the Unique Hdcf Loop. Biochem.J., 455, 2013
2PJ1	CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B (3-Aminomethyl-phenyl)-[((R)-1-benzyloxycarbonylamino-2-methyl-propyl)-hydroxy-phosphinoyloxy]-acetic acid COMPLEX 分子名称: (5R,6S,8S)-8-[3-(AMINOMETHYL)PHENYL]-6-HYDROXY-5-ISOPROPYL-3-OXO-1-PHENYL-2,7-DIOXA-4-AZA-6-PHOSPHANONAN-9-OIC ACID 6-OXIDE, Carboxypeptidase B, ZINC ION 著者 Adler, M, Whitlow, M. 登録日 2007-04-15 公開日 2008-01-22 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Structures of potent selective peptide mimetics bound to carboxypeptidase B. Acta Crystallogr.,Sect.D, 64, 2008
4ZE0	Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140F mutant complexed with Voriconazole 分子名称: Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, Voriconazole 著者 Sagatova, A, Keniya, M.V, Wilson, R, Tyndall, J.D.A, Monk, B.C. 登録日 2015-04-20 公開日 2016-03-30 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase. Sci Rep, 6, 2016
4ZDZ	Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140F mutant complexed with fluconazole 分子名称: 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE 著者 Sagatova, A, Keniya, M.V, Wilson, R.K, Tyndall, J.D.A, Monk, B.C. 登録日 2015-04-20 公開日 2016-03-30 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase. Sci Rep, 6, 2016
4ZGM	Crystal structure of Semaglutide peptide backbone in complex with the GLP-1 receptor extracellular domain 分子名称: 3,6,9,12,15,18-hexaoxahexacosan-1-ol, Glucagon-like peptide 1 receptor, Semaglutide peptide backbone; 8Aib,34R-GLP-1(7-37)-OH 著者 Reedtz-Runge, S. 登録日 2015-04-23 公開日 2015-09-09 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide. J.Med.Chem., 58, 2015

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