2P1V

Crystal structure of the ligand binding domain of the retinoid X receptor alpha in complex with 3-(2'-propoxy)-tetrahydronaphtyl cinnamic acid and a fragment of the coactivator TIF-2

Summary for 2P1V

Entry DOI	10.2210/pdb2p1v/pdb
Related	1FBY 1LBD 1MVC 1XDK 2p1t 2p1u
Descriptor	Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2 peptide, (2E)-3-[4-HYDROXY-3-(5,5,8,8-TETRAMETHYL-3-PROPOXY-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)PHENYL]ACRYLIC ACID, ... (4 entities in total)
Functional Keywords	protein-ligand complex, hormone receptor
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: P19793 Q15596
Total number of polymer chains	2
Total formula weight	28844.43
Authors	Bourguet, W.,Nahoum, V. (deposition date: 2007-03-06, release date: 2007-10-09, Last modification date: 2023-08-30)
Primary citation	Nahoum, V.,Perez, E.,Germain, P.,Rodriguez-Barrios, F.,Manzo, F.,Kammerer, S.,Lemaire, G.,Hirsch, O.,Royer, C.A.,Gronemeyer, H.,de Lera, A.R.,Bourguet, W. Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function. Proc.Natl.Acad.Sci.Usa, 104:17323-17328, 2007 Cited by PubMed: 17947383 DOI: 10.1073/pnas.0705356104 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation