2P1T
Crystal structure of the ligand binding domain of the retinoid X receptor alpha in complex with 3-(2'-methoxy)-tetrahydronaphtyl cinnamic acid and a fragment of the coactivator TIF-2
Summary for 2P1T
Entry DOI | 10.2210/pdb2p1t/pdb |
Related | 1FBY 1LBD 1MVC 1XDK 2p1u 2p1v |
Descriptor | Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2 peptide, (2E)-3-[4-HYDROXY-3-(3-METHOXY-5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)PHENYL]ACRYLIC ACID, ... (4 entities in total) |
Functional Keywords | protein-ligand complex, hormone receptor |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: P19793 Q15596 |
Total number of polymer chains | 2 |
Total formula weight | 28816.38 |
Authors | Bourguet, W.,Nahoum, V. (deposition date: 2007-03-06, release date: 2007-10-09, Last modification date: 2023-08-30) |
Primary citation | Nahoum, V.,Perez, E.,Germain, P.,Rodriguez-Barrios, F.,Manzo, F.,Kammerer, S.,Lemaire, G.,Hirsch, O.,Royer, C.A.,Gronemeyer, H.,de Lera, A.R.,Bourguet, W. Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function. Proc.Natl.Acad.Sci.Usa, 104:17323-17328, 2007 Cited by PubMed: 17947383DOI: 10.1073/pnas.0705356104 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report