1XDK

Crystal Structure of the RARbeta/RXRalpha Ligand Binding Domain Heterodimer in Complex with 9-cis Retinoic Acid and a Fragment of the TRAP220 Coactivator

Summary for 1XDK

• Entry DOI: 10.2210/pdb1xdk/pdb
• Related: 1DKF
• Descriptor: Retinoic acid receptor RXR-alpha, Retinoic acid receptor, beta, Thyroid Receptor Associated Protein 220, ... (5 entities in total)
• Functional Keywords: nuclear receptor, coactivator, ligand, hormone-growth factor receptor complex, hormone/growth factor receptor
• Biological source: Mus musculus (house mouse); More
• Cellular location: Nucleus: P28700 P22605
• Total number of polymer chains: 8
• Total formula weight: 128757.06

Authors

Pogenberg, V.,Guichou, J.F.,Vivat-Hannah, V.,Kammerer, S.,Perez, E.,Germain, P.,De Lera, A.R.,Gronemeyer, H.,Royer, C.A.,Bourguet, W. (deposition date: 2004-09-07, release date: 2004-11-09, Last modification date: 2023-08-23)

• Primary citation: Pogenberg, V.,Guichou, J.F.,Vivat-Hannah, V.,Kammerer, S.,Perez, E.,Germain, P.,De Lera, A.R.,Gronemeyer, H.,Royer, C.A.,Bourguet, W.; CHARACTERIZATION OF THE INTERACTION BETWEEN RAR/RXR HETERODIMERS AND TRANSCRIPTIONAL COACTIVATORS THROUGH STRUCTURAL AND FLUORESCENCE ANISOTROPY STUDIES; J.Biol.Chem., 280:1625-1633, 2005; PubMed: 15528208; DOI: 10.1074/jbc.M409302200

Experimental method

X-RAY DIFFRACTION (2.9 Å)