1XDK
Crystal Structure of the RARbeta/RXRalpha Ligand Binding Domain Heterodimer in Complex with 9-cis Retinoic Acid and a Fragment of the TRAP220 Coactivator
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003707 | molecular_function | nuclear steroid receptor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0008270 | molecular_function | zinc ion binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0004879 | molecular_function | nuclear receptor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0048384 | biological_process | retinoic acid receptor signaling pathway |
| E | 0003677 | molecular_function | DNA binding |
| E | 0003707 | molecular_function | nuclear steroid receptor activity |
| E | 0005634 | cellular_component | nucleus |
| E | 0006355 | biological_process | regulation of DNA-templated transcription |
| E | 0008270 | molecular_function | zinc ion binding |
| F | 0003677 | molecular_function | DNA binding |
| F | 0004879 | molecular_function | nuclear receptor activity |
| F | 0005634 | cellular_component | nucleus |
| F | 0006355 | biological_process | regulation of DNA-templated transcription |
| F | 0048384 | biological_process | retinoic acid receptor signaling pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 9CR A 500 |
| Chain | Residue |
| A | ALA276 |
| A | HIS440 |
| A | LEU441 |
| A | HOH706 |
| A | GLN280 |
| A | TRP310 |
| A | PHE318 |
| A | ARG321 |
| A | LEU331 |
| A | ALA332 |
| A | VAL347 |
| A | CYS437 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 9CR B 600 |
| Chain | Residue |
| B | PHE192 |
| B | ALA225 |
| B | CYS228 |
| B | LEU262 |
| B | ILE263 |
| B | ARG269 |
| B | PHE279 |
| B | SER280 |
| B | GLY294 |
| B | PHE295 |
| B | LEU298 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 9CR E 1500 |
| Chain | Residue |
| E | ALA276 |
| E | GLN280 |
| E | TRP310 |
| E | PHE318 |
| E | ARG321 |
| E | LEU331 |
| E | ALA332 |
| E | VAL347 |
| E | CYS437 |
| E | HIS440 |
| E | LEU441 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 9CR F 1600 |
| Chain | Residue |
| F | PHE192 |
| F | ALA225 |
| F | CYS228 |
| F | LEU262 |
| F | ILE263 |
| F | ARG269 |
| F | PHE279 |
| F | SER280 |
| F | GLY294 |
| F | PHE295 |
| F | LEU298 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 48 |
| Details | ZN_FING: NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 |
| Chain | Residue | Details |
| B | VAL151-ALA175 | |
| F | VAL151-ALA175 | |
| E | ARG321 | |
| E | ALA332 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P19793 |
| Chain | Residue | Details |
| A | SER264 | |
| E | SER264 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by MAPK8 and MAPK9 => ECO:0000269|PubMed:10383391 |
| Chain | Residue | Details |
| A | SER265 | |
| E | SER265 |
