4ZE0
Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140F mutant complexed with Voriconazole
Summary for 4ZE0
| Entry DOI | 10.2210/pdb4ze0/pdb |
| Related | 4K0F 4LXJ 4WMZ 4ZDY 4ZDZ 4ZE1 4ZE2 4ZE3 |
| Descriptor | Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE, Voriconazole, ... (4 entities in total) |
| Functional Keywords | cyp51, oxidoreductase-oxidoreducatse inhibitor complex, y140f, resistance mutation, oxidoreductase/oxidoreducatse inhibitor |
| Biological source | Saccharomyces cerevisiae (strain YJM789) (Baker's yeast) |
| Total number of polymer chains | 1 |
| Total formula weight | 62835.01 |
| Authors | Sagatova, A.,Keniya, M.V.,Wilson, R.,Tyndall, J.D.A.,Monk, B.C. (deposition date: 2015-04-20, release date: 2016-03-30, Last modification date: 2024-03-13) |
| Primary citation | Sagatova, A.A.,Keniya, M.V.,Wilson, R.K.,Sabherwal, M.,Tyndall, J.D.,Monk, B.C. Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase. Sci Rep, 6:26213-26213, 2016 Cited by PubMed: 27188873DOI: 10.1038/srep26213 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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