4ZE0

Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140F mutant complexed with Voriconazole

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Lanosterol 14-alpha demethylase	polymer	539	61869.2	1	UniProt (A6ZSR0) Pfam (PF00067) In PDB	Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
2	A	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	1	Chemie (HEM)
3	A	Voriconazole	non-polymer		349.3	1	Chemie (VOR)
4		water	water		18.0	172	Chemie (HOH)

Sequence modifications

A: 1 - 530 (UniProt: A6ZSR0)

PDB	External Database	Details
Phe 140	Tyr 140	engineered mutation
Gly 531	-	expression tag
Gly 532	-	expression tag
Arg 533	-	expression tag
His 534	-	expression tag
His 535	-	expression tag
His 536	-	expression tag
His 537	-	expression tag
His 538	-	expression tag
His 539	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	61869.2
Non-Polymers*	Number of molecules	2
	Total formula weight	965.8
All*	Total formula weight	62835.0

*Water molecules are not included.